SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-S21B10
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8gdr
Q-score: 0.411
Patel A, Kumar S, Lai L, Chakravarthy C, Valanparambil R, Keen M, Laughlin ZT, Frank F, Cheedarla N, Verkerke HP, Neish AS, Roback JD, Davis CW, Wrammert J, Ahmed R, Suthar MS, Murali-Krishna K, Chandele A, Ortlund EA
To Be Published
- Spike glycoprotein (128 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Antibody 002-s21b10 (Complex from Homo sapiens)
- Spike glycoprotein trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- Antibody 002-s21b10 bound to spike glycoprotein trimer (Complex)
- Monoclonal antibody 002-s21b10 light chain variable domain (22 kDa, Protein from Homo sapiens)
- Monoclonal antibody 002-s21b10 heavy chain variable domain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Patel A, Kumar S, Lai L, Chakravarthy C, Valanparambil R, Keen M, Laughlin ZT, Frank F, Cheedarla N, Verkerke HP, Neish AS, Roback JD, Davis CW, Wrammert J, Ahmed R, Suthar MS, Murali-Krishna K, Chandele A, Ortlund EA
To Be Published
Patel A, Kumar S, Lai L, Chakravarthy C, Valanparambil R, Keen M, Laughlin ZT, Frank F, Cheedarla N, Verkerke HP, Neish AS, Roback JD, Davis CW, Wrammert J, Ahmed R, Suthar MS, Murali-Krishna K, Chandele A, Ortlund EA
To Be Published
SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 034_32
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7uow
Q-score: 0.268
Patel A, Kumar S, Lai L, Chakravarthy C, Valanparambil R, Reddy ES, Gottimukkala K, Bajpai P, Raju DR, Edara VV, Davis-Gardner ME, Linderman S, Dixit K, Sharma P, Mantus G, Cheedarla N, Verkerke HP, Frank F, Neish AS, Roback JD, Davis CW, Wrammert J, Ahmed R, Suthar MS, Sharma A, Murali-Krishna K, Chandele A, Ortlund EA
Structure (2023) 31 pp. 801-811.e5 [ Pubmed: 37167972 DOI: doi:10.1016/j.str.2023.04.010 ]
- Sars-cov2 spike trimer in complex with monoclonal antibody (Complex)
- Monoclonal antibody 034_32 light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Mab 034-32 heavy chain, mab 034-32 light chain (Complex from Homo sapiens)
- Monoclonal antibody 034_32 heavy chain (48 kDa, Protein from Homo sapiens)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-02
Resolution: 3.86 Å
EM Method: Single-particle
Fitted PDBs: 7u0q
Q-score: 0.324
Patel A, Kumar S, Lai L, Chakravarthy C, Valanparambil R, Reddy ES, Gottimukkala K, Bajpai P, Raju DR, Edara VV, Davis-Gardner ME, Linderman S, Dixit K, Sharma P, Mantus G, Cheedarla N, Verkerke HP, Frank F, Neish AS, Roback JD, Davis CW, Wrammert J, Ahmed R, Suthar MS, Sharma A, Murali-Krishna K, Chandele A, Ortlund EA
Structure (2023) 31 pp. 801-811.e5 [ Pubmed: 37167972 DOI: doi:10.1016/j.str.2023.04.010 ]
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Mab 002-02 light chain, mab 002-02 heavy chain (Complex from Homo sapiens)
- Mab 002-02 heavy chain (49 kDa, Protein from Homo sapiens)
- Mab 002-02 light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Cov2 spike timer in complex with monoclonal antibody (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-13
Resolution: 3.82 Å
EM Method: Single-particle
Fitted PDBs: 7u0x
Q-score: 0.304
Patel A, Kumar S, Lai L, Chakravarthy C, Valanparambil R, Reddy ES, Gottimukkala K, Bajpai P, Raju DR, Edara VV, Davis-Gardner ME, Linderman S, Dixit K, Sharma P, Mantus G, Cheedarla N, Verkerke HP, Frank F, Neish AS, Roback JD, Davis CW, Wrammert J, Ahmed R, Suthar MS, Sharma A, Murali-Krishna K, Chandele A, Ortlund EA
Structure (2023) 31 pp. 801-811.e5 [ Pubmed: 37167972 DOI: doi:10.1016/j.str.2023.04.010 ]
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Mab 002-13 heavy chain, mab 002-13 light chain (Complex from Homo sapiens)
- Cov2 spike timer in complex with monoclonal antibody (Complex)
- Mab 002-13 heavy chain (50 kDa, Protein from Homo sapiens)
- Mab 002-13 light chain (23 kDa, Protein from Homo sapiens)
SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-S21F2
Resolution: 3.76 Å
EM Method: Single-particle
Fitted PDBs: 7u0p
Q-score: 0.366
Kumar S, Patel A, Lai L, Chakravarthy C, Valanparambil R, Reddy ES, Gottimukkala K, Davis-Gardner ME, Edara VV, Linderman S, Nayak K, Dixit K, Sharma P, Bajpai P, Singh V, Frank F, Cheedarla N, Verkerke HP, Neish AS, Roback JD, Mantus G, Goel PK, Rahi M, Davis CW, Wrammert J, Godbole S, Henry AR, Douek DC, Suthar MS, Ahmed R, Ortlund E, Sharma A, Murali-Krishna K, Chandele A
Sci Adv (2022) 8 pp. eadd2032-eadd2032 [ Pubmed: 36197988 DOI: doi:10.1126/sciadv.add2032 ]
- Sars-cov2 spike trimer in complex with monoclonal antibody (Complex)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Mab 002_s21f2 light chain (23 kDa, Protein from Homo sapiens)
- Mab 002-s21f2 (Complex from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Mab 002-s21f2 heavy chain (49 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7upl
Q-score: 0.359
Kumar S, Patel A, Lai L, Chakravarthy C, Valanparambil R, Reddy ES, Gottimukkala K, Davis-Gardner ME, Edara VV, Linderman S, Nayak K, Dixit K, Sharma P, Bajpai P, Singh V, Frank F, Cheedarla N, Verkerke HP, Neish AS, Roback JD, Mantus G, Goel PK, Rahi M, Davis CW, Wrammert J, Godbole S, Henry AR, Douek DC, Suthar MS, Ahmed R, Ortlund E, Sharma A, Murali-Krishna K, Chandele A
Sci Adv (2022) 8 pp. eadd2032-eadd2032 [ Pubmed: 36197988 DOI: doi:10.1126/sciadv.add2032 ]
- Sars-cov2 spike trimer in complex with monoclonal antibody (Complex)
- Mab 002-s21f2 (Complex from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (138 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Mab 002-s21f2 light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mab 002-s21f2 heavy chain (49 kDa, Protein from Homo sapiens)
Monoclonal antibody 1C01 binds stem domain of influenza virus hemagglutinin
Ellebedy AH, Nachbagauer R, Jackson KJL, Dai YN, Han J, Alsoussi WB, Davis CW, Stadlbauer D, Rouphael N, Chromikova V, McCausland M, Chang CY, Cortese M, Bower M, Chennareddy C, Schmitz AJ, Zarnitsyna VI, Lai L, Rajabhathor A, Kazemian C, Antia R, Mulligan MJ, Ward AB, Fremont DH, Boyd SD, Pulendran B, Krammer F, Ahmed R
PNAS (2020) 117 pp. 17957-17964 [ Pubmed: 32661157 DOI: doi:10.1073/pnas.1906613117 ]
Monoclonal antibody 1F03 binds head domain of influenza virus hemagglutinin
Ellebedy AH, Nachbagauer R, Jackson KJL, Dai YN, Han J, Alsoussi WB, Davis CW, Stadlbauer D, Rouphael N, Chromikova V, McCausland M, Chang CY, Cortese M, Bower M, Chennareddy C, Schmitz AJ, Zarnitsyna VI, Lai L, Rajabhathor A, Kazemian C, Antia R, Mulligan MJ, Ward AB, Fremont DH, Boyd SD, Pulendran B, Krammer F, Ahmed R
PNAS (2020) 117 pp. 17957-17964 [ Pubmed: 32661157 DOI: doi:10.1073/pnas.1906613117 ]