SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-S21B10
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8gdr
Q-score: 0.411
Patel A, Kumar S, Lai L, Chakravarthy C, Valanparambil R, Keen M, Laughlin ZT, Frank F, Cheedarla N, Verkerke HP, Neish AS, Roback JD, Davis CW, Wrammert J, Ahmed R, Suthar MS, Murali-Krishna K, Chandele A, Ortlund EA
To Be Published
- Spike glycoprotein (128 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Antibody 002-s21b10 (Complex from Homo sapiens)
- Spike glycoprotein trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- Antibody 002-s21b10 bound to spike glycoprotein trimer (Complex)
- Monoclonal antibody 002-s21b10 light chain variable domain (22 kDa, Protein from Homo sapiens)
- Monoclonal antibody 002-s21b10 heavy chain variable domain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of EBOV GP lacking the mucin-like domain with 2.1.1D5 scFv and 6D6 scFv bound
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8dpl
Q-score: 0.536
Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO
Cell Rep (2023) 42 pp. 113366-113366 [ DOI: doi:10.1016/j.celrep.2023.113366 Pubmed: 37938974 ]
- Glycoprotein gp1 (31 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Structure of ebov gp in complex with 2.1.1d5 scfv and 6d6 scfv (Complex from Ebola virus - Mayinga, Zaire, 1976)
- 2.1.1d5 light chain variable domain (11 kDa, Protein from Homo sapiens)
- Glycoprotein gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- 2.1.1d5 heavy chain variable domain (13 kDa, Protein from Homo sapiens)
- 6d6 single-chain variable fragment (25 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of EBOV GP lacking the mucin-like domain with 9.20.1A2 Fab and 6D6 scFv bound
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8dpm
Q-score: 0.505
Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO
Cell Rep (2023) 42 pp. 113366-113366 [ DOI: doi:10.1016/j.celrep.2023.113366 Pubmed: 37938974 ]
- Glycoprotein gp1 (31 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Antibody 6d6 scfv (25 kDa, Protein from Mus musculus)
- Complex of ebola virus glycoprotein trimer with 1a2 antibody fab and 6d6 antibody scfv (Complex from Ebola virus - Mayinga, Zaire, 1976)
- Glycoprotein gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Antibody 9.20.1a2 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Antibody 9.20.1a2 fab light chain (11 kDa, Protein from Homo sapiens)
- Antibody 9.20.1a2 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of EBOV GP lacking the mucin-like domain with 1C11 scFv and 1C3 Fab bound
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 7swd
Q-score: 0.449
Milligan JC, Davis CW, Yu X, Ilinykh PA, Huang K, Halfmann PJ, Cross RW, Borisevich V, Agans KN, Geisbert JB, Chennareddy C, Goff AJ, Piper AE, Hui S, Shaffer KCL, Buck T, Heinrich ML, Branco LM, Crozier I, Holbrook MR, Kuhn JH, Kawaoka Y, Glass PJ, Bukreyev A, Geisbert TW, Worwa G, Ahmed R, Saphire EO
Cell (2022) 185 pp. 995-1007.e18 [ DOI: doi:10.1016/j.cell.2022.02.023 Pubmed: 35303429 ]
- Complex of ebov gp lacking the mucin-like-domain with 1c11 scfv and 1c3 fab (300 kDa, Complex from Homo sapiens)
- Virion spike glycoprotein gp1 (31 kDa, Protein from Ebola virus - Gabon (1994-1997))
- Virion spike glycoprotein gp2 (10 kDa, Protein from Zaire ebolavirus)
- 1c3 heavy chain (13 kDa, Protein from Homo sapiens)
- 1c11 scfv (26 kDa, Protein from Homo sapiens)
- 1c3 light chain (12 kDa, Protein from Homo sapiens)