S. cerevisia Niemann-Pick type C protein NCR1 in GDN at pH 7.5
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8qeb
Q-score: 0.472
Frain KM, Dedic E, Nel L, Bohush A, Olesen E, Thaysen K, Wustner D, Stokes DL, Pedersen BP
PNAS (2024) 121 pp. e2315575121-e2315575121 [ Pubmed: 38568972 DOI: doi:10.1073/pnas.2315575121 ]
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Ncr1 ph 7.5 in gdn (132 kDa, Complex from Saccharomyces cerevisiae)
- Npc intracellular sterol transporter 1-related protein 1 (132 kDa, Protein from Saccharomyces cerevisiae)
- Ergosterol (396 Da, Ligand)
S. cerevisia Niemann-Pick type C protein NCR1 in GDN at pH 5.5
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8qec
Q-score: 0.487
Frain KM, Dedic E, Nel L, Bohush A, Olesen E, Thaysen K, Wustner D, Stokes DL, Pedersen BP
PNAS (2024) 121 pp. e2315575121-e2315575121 [ Pubmed: 38568972 DOI: doi:10.1073/pnas.2315575121 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Ncr1 in gdn at ph 5.5 (132 kDa, Complex from Saccharomyces cerevisiae)
- Npc intracellular sterol transporter 1-related protein 1 (132 kDa, Protein from Saccharomyces cerevisiae)
- Ergosterol (396 Da, Ligand)
- 2-{[(4-o-alpha-d-glucopyranosyl-alpha-d-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25r)-spirost-5-en-3-yl]oxy}butyl 4-o-alpha-d-glucopyranosyl-alpha-d-glucopyranoside (1 kDa, Ligand)
S. cerevisia Niemann-Pick type C protein NCR1 in LMNG at pH 5.5
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 8qed
Q-score: 0.477
Frain KM, Dedic E, Nel L, Bohush A, Olesen E, Thaysen K, Wustner D, Stokes DL, Pedersen BP
PNAS (2024) 121 pp. e2315575121-e2315575121 [ Pubmed: 38568972 DOI: doi:10.1073/pnas.2315575121 ]
- Phosphatidylethanolamine (734 Da, Ligand)
- Npc intracellular sterol transporter 1-related protein 1 (132 kDa, Protein from Saccharomyces cerevisiae)
- Ergosterol (396 Da, Ligand)
- Ncr1 ph 5.5 in lmng (132 kDa, Complex from Saccharomyces cerevisiae)
S. cerevisia Niemann-Pick type C protein NCR1 in Peptidisc at pH 7.5
Resolution: 2.43 Å
EM Method: Single-particle
Fitted PDBs: 8qee
Q-score: 0.638
Frain KM, Dedic E, Nel L, Bohush A, Olesen E, Thaysen K, Wustner D, Stokes DL, Pedersen BP
PNAS (2024) 121 pp. e2315575121-e2315575121 [ Pubmed: 38568972 DOI: doi:10.1073/pnas.2315575121 ]
- Ncr1 ph 7.5 in peptidisc (132 kDa, Complex from Saccharomyces cerevisiae)
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Npc intracellular sterol transporter 1-related protein 1 (132 kDa, Protein from Saccharomyces cerevisiae)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Outward-facing apo-form of auxin transporter PIN8
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 7qp9
Q-score: 0.572
Ung KL, Winkler M, Schulz L, Kolb M, Janacek DP, Dedic E, Stokes DL, Hammes UZ, Pedersen BP
Nature (2022) 609 pp. 605-610 [ Pubmed: 35768502 DOI: doi:10.1038/s41586-022-04883-y ]
- Auxin efflux carrier component 8 (41 kDa, Protein from Arabidopsis thaliana)
- Water (18 Da, Ligand)
- Apo-form of pin8 (81 kDa, Complex from Arabidopsis thaliana)
- 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (782 Da, Ligand)
Outward-facing auxin bound form of auxin transporter PIN8
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 7qpa
Q-score: 0.505
Ung KL, Winkler M, Schulz L, Kolb M, Janacek DP, Dedic E, Stokes DL, Hammes UZ, Pedersen BP
Nature (2022) 609 pp. 605-610 [ Pubmed: 35768502 DOI: doi:10.1038/s41586-022-04883-y ]
- Water (18 Da, Ligand)
- 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (782 Da, Ligand)
- Iaa bound form of pin8 (81 kDa, Complex from Arabidopsis thaliana)
- Auxin efflux carrier component 8 (41 kDa, Protein from Arabidopsis thaliana)
- 1h-indol-3-ylacetic acid (175 Da, Ligand)
Inward-facing NPA bound form of auxin transporter PIN8
Resolution: 3.44 Å
EM Method: Single-particle
Fitted PDBs: 7qpc
Q-score: 0.501
Ung KL, Winkler M, Schulz L, Kolb M, Janacek DP, Dedic E, Stokes DL, Hammes UZ, Pedersen BP
Nature (2022) 609 pp. 605-610 [ Pubmed: 35768502 DOI: doi:10.1038/s41586-022-04883-y ]
- Water (18 Da, Ligand)
- 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (782 Da, Ligand)
- Npa-form of pin8 (81 kDa, Complex from Arabidopsis thaliana)
- Auxin efflux carrier component 8 (41 kDa, Protein from Arabidopsis thaliana)
- 2-(naphthalen-1-ylcarbamoyl)benzoic acid (291 Da, Ligand)
Outward-facing apo-form of auxin transporter PIN8 in detergent
Ung KL, Winkler M, Schulz L, Kolb M, Janacek DP, Dedic E, Stokes DL, Hammes UZ, Pedersen BP
Nature (2022) 609 pp. 605-610 [ Pubmed: 35768502 DOI: doi:10.1038/s41586-022-04883-y ]