Human leukocyte antigen bound by two alloreactive antibody Fabs
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8t6m
Q-score: 0.498
Killian JT, King RG, Kizziah JL, Fucile CF, Diaz-Avalos R, Qiu S, Silva-Sanchez A, Mousseau BJ, Macon KJ, Callahan AR, Yang G, Hossain ME, Akther J, Houp JA, Rosenblum FD, Porrett PM, Ong SC, Kumar V, Mobley JA, Saphire EO, Kearney JF, Randall TD, Rosenberg AF, Green TJ, Lund FE
To Be Published
- Jtk191b_m07_light (23 kDa, Protein from Homo sapiens)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
- Mhc class i antigen (20 kDa, Protein from Homo sapiens)
- Hla_a0101_peptide (1 kDa, Protein from Homo sapiens)
- Jtk191b_l02_fab (23 kDa, Protein from Homo sapiens)
- Jtk191b_l02_light (23 kDa, Protein from Homo sapiens)
- L02/m07/a*01:01 complex (Complex from Homo sapiens)
- Jtk191b_m07_fab (24 kDa, Protein from Homo sapiens)
Pre-fusion Measles virus fusion protein complexed with Fab 77
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8ut2
Q-score: 0.583
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Ollmann Saphire E
Science (2024) 384 pp. eadm8693-eadm8693 [ DOI: doi:10.1126/science.adm8693 Pubmed: 38935733 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fusion glycoprotein f0 (44 kDa, Protein from Measles morbillivirus)
- Antibody 77 fab heavy chain, antibody 77 fab light chain (Complex from Mus musculus)
- Fusion glycoprotein f0 (12 kDa, Protein from Measles morbillivirus)
- Mab 77 light chain (25 kDa, Protein from Mus musculus)
- Mab 77 heavy chain (52 kDa, Protein from Mus musculus)
- Measles virus fusion glycoprotein (Complex from Measles morbillivirus)
- Water (18 Da, Ligand)
- Structure of measles fusion glycoprotein in complex with fab 77 (Complex)
Structure of the Measles virus Fusion protein in the post-fusion conformation
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8utf
Q-score: 0.572
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Ollmann Saphire E
Science (2024) 384 pp. eadm8693-eadm8693 [ DOI: doi:10.1126/science.adm8693 Pubmed: 38935733 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fusion glycoprotein f0 (12 kDa, Protein from Measles virus strain Ichinose-B95a)
- Fusion glycoprotein f0 (44 kDa, Protein from Measles virus strain Ichinose-B95a)
- Water (18 Da, Ligand)
- Structure of the measles virus fusion protein in the post-fusion conformation (Complex from Measles virus strain Ichinose-B95a)
Structure of the Measles virus Fusion protein in the pre-fusion conformation
Resolution: 2.11 Å
EM Method: Single-particle
Fitted PDBs: 8uup
Q-score: 0.637
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Ollmann Saphire E
Science (2024) 384 pp. eadm8693-eadm8693 [ DOI: doi:10.1126/science.adm8693 Pubmed: 38935733 ]
- Structure of the measles virus fusion protein in the pre-fusion conformation (Complex from Measles virus strain Ichinose-B95a)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fusion glycoprotein f0 (44 kDa, Protein from Measles virus strain Ichinose-B95a)
- Fusion glycoprotein f0 (12 kDa, Protein from Measles virus strain Ichinose-B95a)
- Water (18 Da, Ligand)
Resolution: 2.34 Å
EM Method: Single-particle
Fitted PDBs: 8uuq
Q-score: 0.663
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Ollmann Saphire E
Science (2024) 384 pp. eadm8693-eadm8693 [ DOI: doi:10.1126/science.adm8693 Pubmed: 38935733 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fusion glycoprotein f0 (12 kDa, Protein from Measles virus strain Ichinose-B95a)
- Structure of the measles virus fusion protein in the pre-fusion conformation with bound [fip-hrc]2-peg11 (Complex from Measles virus strain Ichinose-B95a)
- [fip-hrc]2-peg11 (503 Da, Protein from synthetic construct)
- Fusion glycoprotein f0 (44 kDa, Protein from Measles virus strain Ichinose-B95a)
- Water (18 Da, Ligand)
Fab 77-stabilized MeV F ectodomain fragment
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9at8
Q-score: 0.444
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Ollmann Saphire E
Science (2024) 384 pp. eadm8693-eadm8693 [ DOI: doi:10.1126/science.adm8693 Pubmed: 38935733 ]
- Fusion glycoprotein f0 (57 kDa, Protein from Measles virus strain Ichinose-B95a)
- Mab 77 heavy chain (52 kDa, Protein from Homo sapiens)
- Mab 77 light chain (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Measles virus fusion glycoprotein (Complex from Measles virus strain Ichinose-B95a)
- Antibody 77 fab heavy chain, antibody 77 fab light chain (Complex from Mus musculus)
- Fab 77-stabilized mev f ectodomain fragment (43 kDa, Complex)
Lymphocytic choriomeningitis virus glycoprotein in complex with neutralizing antibody M28
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8dmh
Q-score: 0.515
Moon-Walker A, Zhang Z, Zyla DS, Buck TK, Li H, Diaz Avalos R, Schendel SL, Hastie KM, Crotty S, Saphire EO
Cell Chem Biol (2023) 30 pp. 403-411.e4 [ Pubmed: 36990092 DOI: doi:10.1016/j.chembiol.2023.03.005 ]
- Lymphocytic choriomeningitis virus glycoprotein in complex with neutralizing antibody m28 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein g1 (25 kDa, Protein from Lymphocytic choriomeningitis virus)
- 18.5c-m28 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Glycoprotein (Complex from Lymphocytic choriomeningitis mammarenavirus)
- Glycoprotein g2,cobalamin adenosyltransferase-like domain-containing protein trimerization tag (42 kDa, Protein from Lymphocytic choriomeningitis virus)
- 18.5c-m28 fab light chain (23 kDa, Protein from Homo sapiens)
- 18.5c-m28 fab light chain, 18.5c-m28 fab heavy chain (Complex from Homo sapiens)
Lymphocytic choriomeningitis virus glycoprotein
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8dmi
Q-score: 0.454
Moon-Walker A, Zhang Z, Zyla DS, Buck TK, Li H, Diaz Avalos R, Schendel SL, Hastie KM, Crotty S, Saphire EO
Cell Chem Biol (2023) 30 pp. 403-411.e4 [ Pubmed: 36990092 DOI: doi:10.1016/j.chembiol.2023.03.005 ]
- Glycoprotein g2,cobalamin adenosyltransferase-like domain-containing protein trimerization tag (42 kDa, Protein from Lymphocytic choriomeningitis virus)
- Lymphocytic choriomeningitis virus glycoprotein (Complex from Lymphocytic choriomeningitis mammarenavirus)
- Glycoprotein g1 (25 kDa, Protein from Lymphocytic choriomeningitis virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 7uot
Q-score: 0.559
Li H, Buck T, Zandonatti M, Yin J, Moon-Walker A, Fang J, Koval A, Heinrich ML, Rowland MM, Diaz Avalos R, Schendel SL, Parekh D, Zyla D, Enriquez A, Harkins S, Sullivan B, Smith V, Chukwudozie O, Watanabe R, Robinson JE, Garry RF, Branco LM, Hastie KM, Saphire EO
Sci Transl Med (2022) 14 pp. eabq0991-eabq0991 [ DOI: doi:10.1126/scitranslmed.abq0991 Pubmed: 36288283 ]
- Glycoprotein g2 (26 kDa, Protein from Lassa virus)
- 37.2d light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- 37.2d heavy chain (variable domain) (13 kDa, Protein from Homo sapiens)
- Native lassa glycoprotein in complex with 8.9f-scfv and 37.2d-scfv (Complex)
- 8.9f light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- Glycoprotein g1 (29 kDa, Protein from Lassa virus)
- 8.9f heavy chain (variable domain) (15 kDa, Protein from Homo sapiens)
Native Lassa glycoprotein in complex with neutralizing antibodies 12.1F and 37.2D
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 7uov
Q-score: 0.541
Li H, Buck T, Zandonatti M, Yin J, Moon-Walker A, Fang J, Koval A, Heinrich ML, Rowland MM, Diaz Avalos R, Schendel SL, Parekh D, Zyla D, Enriquez A, Harkins S, Sullivan B, Smith V, Chukwudozie O, Watanabe R, Robinson JE, Garry RF, Branco LM, Hastie KM, Saphire EO
Sci Transl Med (2022) 14 pp. eabq0991-eabq0991 [ DOI: doi:10.1126/scitranslmed.abq0991 Pubmed: 36288283 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 12.1f heavy chain (variable domain) (12 kDa, Protein from Homo sapiens)
- Glycoprotein g2 (26 kDa, Protein from Lassa virus)
- 12.1f light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- 37.2d light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- Glycoprotein g1 (29 kDa, Protein from Lassa virus)
- 37.2d heavy chain (variable domain) (13 kDa, Protein from Homo sapiens)
- Native lassa glycoprotein in complex with 12.1f-scfv and 37.2d-scfv (Complex)