Pre-fusion Measles virus fusion protein complexed with Fab 77
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8ut2
Q-score: 0.583
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Ollmann Saphire E
Science (2024) 384 pp. eadm8693-eadm8693 [ DOI: doi:10.1126/science.adm8693 Pubmed: 38935733 ]
- Water (18 Da, Ligand)
- Antibody 77 fab heavy chain, antibody 77 fab light chain (Complex from Mus musculus)
- Mab 77 light chain (25 kDa, Protein from Mus musculus)
- Measles virus fusion glycoprotein (Complex from Measles morbillivirus)
- Fusion glycoprotein f0 (12 kDa, Protein from Measles morbillivirus)
- Mab 77 heavy chain (52 kDa, Protein from Mus musculus)
- Fusion glycoprotein f0 (44 kDa, Protein from Measles morbillivirus)
- Structure of measles fusion glycoprotein in complex with fab 77 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the Measles virus Fusion protein in the post-fusion conformation
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8utf
Q-score: 0.572
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Ollmann Saphire E
Science (2024) 384 pp. eadm8693-eadm8693 [ DOI: doi:10.1126/science.adm8693 Pubmed: 38935733 ]
- Water (18 Da, Ligand)
- Fusion glycoprotein f0 (44 kDa, Protein from Measles virus strain Ichinose-B95a)
- Fusion glycoprotein f0 (12 kDa, Protein from Measles virus strain Ichinose-B95a)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of the measles virus fusion protein in the post-fusion conformation (Complex from Measles virus strain Ichinose-B95a)
Structure of the Measles virus Fusion protein in the pre-fusion conformation
Resolution: 2.11 Å
EM Method: Single-particle
Fitted PDBs: 8uup
Q-score: 0.637
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Ollmann Saphire E
Science (2024) 384 pp. eadm8693-eadm8693 [ DOI: doi:10.1126/science.adm8693 Pubmed: 38935733 ]
- Water (18 Da, Ligand)
- Structure of the measles virus fusion protein in the pre-fusion conformation (Complex from Measles virus strain Ichinose-B95a)
- Fusion glycoprotein f0 (44 kDa, Protein from Measles virus strain Ichinose-B95a)
- Fusion glycoprotein f0 (12 kDa, Protein from Measles virus strain Ichinose-B95a)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.34 Å
EM Method: Single-particle
Fitted PDBs: 8uuq
Q-score: 0.663
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Ollmann Saphire E
Science (2024) 384 pp. eadm8693-eadm8693 [ DOI: doi:10.1126/science.adm8693 Pubmed: 38935733 ]
- Water (18 Da, Ligand)
- Fusion glycoprotein f0 (44 kDa, Protein from Measles virus strain Ichinose-B95a)
- [fip-hrc]2-peg11 (503 Da, Protein from synthetic construct)
- Structure of the measles virus fusion protein in the pre-fusion conformation with bound [fip-hrc]2-peg11 (Complex from Measles virus strain Ichinose-B95a)
- Fusion glycoprotein f0 (12 kDa, Protein from Measles virus strain Ichinose-B95a)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Fab 77-stabilized MeV F ectodomain fragment
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9at8
Q-score: 0.444
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Ollmann Saphire E
Science (2024) 384 pp. eadm8693-eadm8693 [ DOI: doi:10.1126/science.adm8693 Pubmed: 38935733 ]
- Fab 77-stabilized mev f ectodomain fragment (43 kDa, Complex)
- Antibody 77 fab heavy chain, antibody 77 fab light chain (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mab 77 light chain (25 kDa, Protein from Homo sapiens)
- Measles virus fusion glycoprotein (Complex from Measles virus strain Ichinose-B95a)
- Fusion glycoprotein f0 (57 kDa, Protein from Measles virus strain Ichinose-B95a)
- Mab 77 heavy chain (52 kDa, Protein from Homo sapiens)
SARS-CoV-2 VFLIP_D614G spike glycoprotein in complex with 3 HXL70 Fabs
Olmedillas E, Diaz Avalos R, Ollmann Saphire E
To Be Published