PMCA-amplified alpha-synuclein fibril polymorph, Parkinson's Disease patient-derived seeds
Resolution: 3.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 7ozg
Q-score: 0.476
Frieg B, Geraets JA, Strohaeker T, Dienemann C, Mavroeidi P, Jung BC, Woojin SK, Lee S-J, Xilouri M, Zweckstetter M, Schroeder GF
To Be Published
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
PMCA-amplified alpha-synuclein fibril polymorph, Multiple System Atrophy patient-derived seeds
Resolution: 3.02 Å
EM Method: Helical reconstruction
Fitted PDBs: 7ozh
Q-score: 0.439
Frieg B, Geraets JA, Strohaeker T, Dienemann C, Mavroeidi P, Jung BC, Woojin SK, Lee S-J, Xilouri M, Zweckstetter M, Schroeder GF
To Be Published
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha-synuclein amyloid fibril (Complex from Homo sapiens)
Dimeric form of SARS-CoV-2 RNA-dependent RNA polymerase
Resolution: 5.5 Å
EM Method: Single-particle
Fitted PDBs: 7oyg
Q-score: 0.151
Jochheim FA, Tegunov D, Hillen HS, Schmitzova J, Kokic G, Dienemann C, Cramer P
Communications Biology (2021) 4 pp. 999- [ DOI: doi:10.1038/s42003-021-02529-9 ]
- Sars-cov-2 nsp7 (9 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Rna (5'-r(p*cp*up*ap*cp*gp*cp*ap*gp*up*g)-3') (4 kDa, RNA from Severe acute respiratory syndrome coronavirus 2)
- Rna (5'-r(p*up*gp*cp*ap*cp*up*gp*cp*gp*up*ap*g)-3') (18 kDa, RNA from Severe acute respiratory syndrome coronavirus 2)
- Dimeric form of sars-cov-2 rna-dependent rna polymerase complex (nsp12, nsp7, nsp8) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 nsp8 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- Sars-cov-2 rna-dependent rna polymerase (nsp12) (107 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Structure of replicating SARS-CoV-2 polymerase
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6yyt
Q-score: 0.504
Hillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P
Nature (2020) 584 pp. 154-156 [ DOI: doi:10.1038/s41586-020-2368-8 Pubmed: 32438371 ]
- Rna-dependent rna polymerase complex consisting of nsp12, nsp8, nsp7 and duplex rna. (186 kDa, Complex)
- Duplex rna (Complex from synthetic construct)
- Zinc ion (65 Da, Ligand)
- Rna product (5 kDa, RNA from synthetic construct)
- Nsp8 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Nsp12 (107 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Nsp7 (9 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Nsp8, nsp7 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Nsp12 (Complex from Severe acute respiratory syndrome coronavirus 2)