Cryo-EM 3D model of the 3-RBD up dimeric spike protein of SARS-CoV2 in the presence of SIH-5
Khatri B, Pramanick I, Malladi SK, Rajmani RS, Kumar S, Ghosh P, Sengupta N, Rahisuddin R, Kumar N, Kumaran S, Ringe RP, Varadarajan R, Dutta S, Chatterjee J
Nat Chem Biol (2022) 18 pp. 1046-1055 [ DOI: doi:10.1038/s41589-022-01060-0 Pubmed: 35654847 ]
- Sars-cov2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Peptide sih-5 (Macromolecule from synthetic construct)
- Peptide sih-5 (Complex)
- Sars-cov2 spike protein in the presence of peptide sih-5 (Complex)
- Sars-cov2 spike protein (Macromolecule from Severe acute respiratory syndrome coronavirus 2)
Resolution: 4.47 Å
EM Method: Single-particle
Fitted PDBs: 7x7n
Q-score: 0.348
Khatri B, Pramanick I, Malladi SK, Rajmani RS, Kumar S, Ghosh P, Sengupta N, Rahisuddin R, Kumar N, Kumaran S, Ringe RP, Varadarajan R, Dutta S, Chatterjee J
Nat Chem Biol (2022) 18 pp. 1046-1055 [ DOI: doi:10.1038/s41589-022-01060-0 Pubmed: 35654847 ]
- Sars-cov2 spike protein (Complex from Severe acute respiratory syndrome coronavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Synthetic peptide sih-5 (4 kDa, Protein from synthetic construct)
- Peptide sih-5 (Complex)
- Sars-cov2 spike protein in the presence of peptide sih-5 (Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Apo form metabotropic glutamate receptor 5 with Nanobody 43
Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laermans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK
Nature (2019) 566 pp. 79-84 [ Pubmed: 30675062 DOI: doi:10.1038/s41586-019-0881-4 ]
- Nanobody 43 (Protein from Lama glama)
- Metabotropic glutamate receptor 5 - nb43 complex (220 kDa, Complex from Homo sapiens)
- Metabotropic glutamate receptor 5 (Protein from Homo sapiens)
Metabotropic Glutamate Receptor 5 bound to L-quisqualate and Nb43
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6n51
Q-score: 0.341
Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laermans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK
Nature (2019) 566 pp. 79-84 [ Pubmed: 30675062 DOI: doi:10.1038/s41586-019-0881-4 ]
- Metabotropic glutamate receptor 5 (90 kDa, Protein from Homo sapiens)
- Complex between metabotropic glutamate receptor 5 bound to l-quisqualate and nb43 (220 kDa, Complex from Homo sapiens)
- Nanobody 43 (13 kDa, Protein from Lama glama)
- (s)-2-amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid (189 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Metabotropic Glutamate Receptor 5 Apo Form
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6n52
Q-score: 0.312
Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laermans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK
Nature (2019) 566 pp. 79-84 [ Pubmed: 30675062 DOI: doi:10.1038/s41586-019-0881-4 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Metabotropic glutamate receptor 5 (97 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 5 in nanodiscs (200 kDa, Complex from Homo sapiens)