Earp JC, Garaeva AA, Meikle V, Niederweis M, Seeger MA
Nat Commun (2025) 16 pp. 1934-1934 [ Pubmed: 39994240 DOI: doi:10.1038/s41467-025-56888-6 ]
- Complex of truncated mmpl4 from m. tuberculosis bound to the e. coli acyl carrier protein (113 kDa, Complex from Mycobacterium tuberculosis)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Siderophore exporter mmpl4 (83 kDa, Protein from Mycobacterium tuberculosis)
- Acyl carrier protein (8 kDa, Protein from Escherichia coli MC1061)
Truncated MmpL4 in nanodiscs in absence of substrate
Earp JC, Garaeva AA, Meikle V, Niederweis M, Seeger MA
Nat Commun (2025) 16 pp. 1934-1934 [ Pubmed: 39994240 DOI: doi:10.1038/s41467-025-56888-6 ]
Truncated MmpL4 in nanodiscs in the presence of desferrated mycobactin
Earp JC, Garaeva AA, Meikle V, Niederweis M, Seeger MA
Nat Commun (2025) 16 pp. 1934-1934 [ Pubmed: 39994240 DOI: doi:10.1038/s41467-025-56888-6 ]
- Acyl carrier protein (8 kDa, Protein from Escherichia coli MC1061)
- Mycobactin s (828 Da, Ligand)
- Complex of truncated mmpl4 from m. tuberculosis bound to the e. coli acyl carrier protein and the substrate desferrated mycobactin. (113 kDa, Complex from Mycobacterium tuberculosis)
- Siderophore exporter mmpl4 (83 kDa, Protein from Mycobacterium tuberculosis)
Full-length MmpL4 in complex with the synthetic nanobody Sb09 and the E. coli acyl carrier protein
Earp JC, Garaeva AA, Meikle V, Niederweis M, Seeger MA
Nat Commun (2025) 16 pp. 1934-1934 [ Pubmed: 39994240 DOI: doi:10.1038/s41467-025-56888-6 ]
Truncated MmpL4 mutant R375E/R383E.
Earp JC, Garaeva AA, Meikle V, Niederweis M, Seeger MA
Nat Commun (2025) 16 pp. 1934-1934 [ Pubmed: 39994240 DOI: doi:10.1038/s41467-025-56888-6 ]
- Truncated mmpl4 r375e/r383e. (105 kDa, Complex from Mycobacterium tuberculosis)
Walter JD, Hutter CAJ, Garaeva AA, Scherer M, Zimmermann I, Wyss M, Rheinberger J, Ruedin Y, Earp JC, Egloff P, Sorgenfrei M, Huerlimann LM, Gonda I, Meier G, Remm S, Thavarasah S, Zimmer G, Slotboom DJ, Paulino C, Plattet P, Seeger MA
bioRxiv (2020) [ DOI: doi:10.1101/2020.11.10.376822 ]
- Sars-cov-2 spike protein in complex with sybody#15 and sybody#68 (Complex)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sybody#15 (Protein from synthetic construct)
- Sybody#68 (Protein from synthetic construct)
- Sars-cov-2 spike protein (Protein from Severe acute respiratory syndrome coronavirus 2)
- Sybody#15 and sybody#68 (Complex from synthetic construct)
Walter JD, Hutter CAJ, Garaeva AA, Scherer M, Zimmermann I, Wyss M, Rheinberger J, Ruedin Y, Earp JC, Egloff P, Sorgenfrei M, Huerlimann LM, Gonda I, Meier G, Remm S, Thavarasah S, Zimmer G, Slotboom DJ, Paulino C, Plattet P, Seeger MA
bioRxiv (2020) [ DOI: doi:10.1101/2020.11.10.376822 ]
- Sars-cov-2 spike protein in complex with sybody#15 and sybody#68 (Complex)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sybody#15 (Protein from synthetic construct)
- Sybody#68 (Protein from synthetic construct)
- Sars-cov-2 spike protein (Protein from Severe acute respiratory syndrome coronavirus 2)
- Sybody#15 and sybody#68 (Complex from synthetic construct)
Walter JD, Hutter CAJ, Garaeva AA, Scherer M, Zimmermann I, Wyss M, Rheinberger J, Ruedin Y, Earp JC, Egloff P, Sorgenfrei M, Huerlimann LM, Gonda I, Meier G, Remm S, Thavarasah S, Zimmer G, Slotboom DJ, Paulino C, Plattet P, Seeger MA
bioRxiv (2020) [ DOI: doi:10.1101/2020.11.10.376822 ]
- Sars-cov-2 spike protein in complex with sybody#15 (Complex)
- Sybody#15 (Complex from synthetic construct)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sybody#15 (Protein from synthetic construct)
- Sars-cov-2 spike protein (Protein from Severe acute respiratory syndrome coronavirus 2)
Walter JD, Hutter CAJ, Garaeva AA, Scherer M, Zimmermann I, Wyss M, Rheinberger J, Ruedin Y, Earp JC, Egloff P, Sorgenfrei M, Huerlimann LM, Gonda I, Meier G, Remm S, Thavarasah S, Zimmer G, Slotboom DJ, Paulino C, Plattet P, Seeger MA
bioRxiv (2020) [ DOI: doi:10.1101/2020.11.10.376822 ]
- Sybody#68 (Complex from synthetic construct)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sybody#68 (Protein from synthetic construct)
- Sars-cov-2 spike protein (Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike protein in complex with sybody#68 (Complex)
Cryo-EM map of the SARS-CoV-2 spike protein in complex with sybody#68 in a 1up/2down conformation.
Walter JD, Hutter CAJ, Garaeva AA, Scherer M, Zimmermann I, Wyss M, Rheinberger J, Ruedin Y, Earp JC, Egloff P, Sorgenfrei M, Huerlimann LM, Gonda I, Meier G, Remm S, Thavarasah S, Zimmer G, Slotboom DJ, Paulino C, Plattet P, Seeger MA
bioRxiv (2020) [ DOI: doi:10.1101/2020.11.10.376822 ]