Cryo-EM structure of a Legionella effector complexed with actin and AMP
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8jo3
Q-score: 0.618
Wang T, Song X, Tan J, Xian W, Zhou X, Yu M, Wang X, Xu Y, Wu T, Yuan K, Ran Y, Yang B, Fan G, Liu X, Zhou Y, Zhu Y
Nature (2024) 631 pp. 393-401 [ DOI: doi:10.1038/s41586-024-07573-z Pubmed: 38776962 ]
- Substrate of the dot/icm secretion system (50 kDa, Protein from Legionella sainthelensi)
- Adenosine monophosphate (347 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Actin, alpha skeletal muscle (42 kDa, Protein from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- Cryo-em structure of a legionella effector complexed with actin and amp (Complex from Legionella sainthelensi)
Cryo-EM structure of a Legionella effector complexed with actin and ATP
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8jo4
Q-score: 0.51
Wang T, Song X, Tan J, Xian W, Zhou X, Yu M, Wang X, Xu Y, Wu T, Yuan K, Ran Y, Yang B, Fan G, Liu X, Zhou Y, Zhu Y
Nature (2024) 631 pp. 393-401 [ DOI: doi:10.1038/s41586-024-07573-z Pubmed: 38776962 ]
- Cryo-em structure of a legionella effector complexed with actin and atp (Complex from Legionella sainthelensi)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Actin, alpha skeletal muscle (42 kDa, Protein from Oryctolagus cuniculus)
- Substrate of the dot/icm secretion system (50 kDa, Protein from Legionella sainthelensi)
- Calcium ion (40 Da, Ligand)
III2IV2 respiratory supercomplex from Saccharomyces cerevisiae with 4 bound UQ6
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8e7s
Q-score: 0.312
Hryc CF, Mallampalli VKPS, Bovshik EI, Azinas S, Fan G, Serysheva II, Sparagna GC, Baker ML, Mileykovskaya E, Dowhan W
Nat Commun (2023) 14 pp. 2783-2783 [ DOI: doi:10.1038/s41467-023-38441-5 Pubmed: 37188665 ]
- Cardiolipin (1 kDa, Ligand)
- Cytochrome c oxidase subunit 1 (58 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 5a, mitochondrial (17 kDa, Protein from Saccharomyces cerevisiae)
- Iii2-iv2 mitochondrial respiratory supercomplex (Complex from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit rieske, mitochondrial (23 kDa, Protein from Saccharomyces cerevisiae)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Cytochrome c oxidase subunit 26, mitochondrial (7 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit 6, mitochondrial (17 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 9, mitochondrial (6 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit 10, mitochondrial (8 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 3 (30 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit 1, mitochondrial (50 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit 2, mitochondrial (40 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 4, mitochondrial (17 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c1, heme protein, mitochondrial (34 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b (43 kDa, Protein from Saccharomyces cerevisiae)
- 5-(3,7,11,15,19,23-hexamethyl-tetracosa-2,6,10,14,18,22-hexaenyl)-2,3-dimethoxy-6-methyl-benzene-1,4-diol (592 Da, Ligand)
- Cytochrome c oxidase subunit 6, mitochondrial (17 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit 7, mitochondrial (14 kDa, Protein from Saccharomyces cerevisiae)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Heme-a (852 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phoshocholine (734 Da, Ligand)
- Cytochrome c oxidase subunit 7, mitochondrial (6 kDa, Protein from Saccharomyces cerevisiae)
- (5s,11r)-5,8,11-trihydroxy-5,11-dioxido-17-oxo-4,6,10,12,16-pentaoxa-5,11-diphosphaoctadec-1-yl pentadecanoate (634 Da, Ligand)
- Cytochrome b-c1 complex subunit 8, mitochondrial (10 kDa, Protein from Saccharomyces cerevisiae)
- Copper (ii) ion (63 Da, Ligand)
- Cytochrome c oxidase subunit 8, mitochondrial (8 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 2 (28 kDa, Protein from Saccharomyces cerevisiae)
- Di-palmitoyl-3-sn-phosphatidylethanolamine (691 Da, Ligand)
- Dinuclear copper ion (127 Da, Ligand)
- Cytochrome c oxidase subunit 13, mitochondrial (15 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 12, mitochondrial (9 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit 9, mitochondrial (7 kDa, Protein from Saccharomyces cerevisiae)
III2IV respiratory supercomplex from Saccharomyces cerevisiae cardiolipin-lacking mutant
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ec0
Q-score: 0.307
Hryc CF, Mallampalli VKPS, Bovshik EI, Azinas S, Fan G, Serysheva II, Sparagna GC, Baker ML, Mileykovskaya E, Dowhan W
Nat Commun (2023) 14 pp. 2783-2783 [ DOI: doi:10.1038/s41467-023-38441-5 Pubmed: 37188665 ]
- Iii2-iv mitochondrial respiratory supercomplex (Complex from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 1 (58 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 5a, mitochondrial (17 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit rieske, mitochondrial (23 kDa, Protein from Saccharomyces cerevisiae)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Cytochrome c oxidase subunit 26, mitochondrial (7 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit 6, mitochondrial (17 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 9, mitochondrial (6 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 3 (30 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit 1, mitochondrial (50 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit 2, mitochondrial (40 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 4, mitochondrial (17 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c1, heme protein, mitochondrial (34 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b (43 kDa, Protein from Saccharomyces cerevisiae)
- 5-(3,7,11,15,19,23-hexamethyl-tetracosa-2,6,10,14,18,22-hexaenyl)-2,3-dimethoxy-6-methyl-benzene-1,4-diol (592 Da, Ligand)
- Cytochrome c oxidase subunit 6, mitochondrial (17 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit 7, mitochondrial (14 kDa, Protein from Saccharomyces cerevisiae)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Heme-a (852 Da, Ligand)
- (1s)-2-{[{[(2r)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (751 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phoshocholine (734 Da, Ligand)
- Cytochrome c oxidase subunit 7, mitochondrial (6 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit 8, mitochondrial (10 kDa, Protein from Saccharomyces cerevisiae)
- Copper (ii) ion (63 Da, Ligand)
- Cytochrome c oxidase subunit 8, mitochondrial (8 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 2 (28 kDa, Protein from Saccharomyces cerevisiae)
- Di-palmitoyl-3-sn-phosphatidylethanolamine (691 Da, Ligand)
- Dinuclear copper ion (127 Da, Ligand)
- Cytochrome c oxidase subunit 13, mitochondrial (15 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome c oxidase subunit 12, mitochondrial (9 kDa, Protein from Saccharomyces cerevisiae)
- Cytochrome b-c1 complex subunit 9, mitochondrial (7 kDa, Protein from Saccharomyces cerevisiae)
TRPV2 ion channel gating through allosteric domain coupling revealed by cryo-EM
Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG
Nat. Struct. Mol. Biol. (2018) 26 pp. 40-49 [ DOI: 10.1038/s41594-018-0168-8 Pubmed: 30598551 ]
Image sets:
Open state structure of the full-length TRPV2 cation channel with a resolved pore turret domain
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6bo4
Q-score: 0.347
Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG
Nat Struct Mol Biol (2019) 26 pp. 40-49 [ DOI: doi:10.1038/s41594-018-0168-8 Pubmed: 30598551 ]
- Transient receptor potential cation channel subfamily v member 2 (79 kDa, Protein from Rattus norvegicus)
- Trpv2 (320 kDa, Complex from Rattus norvegicus)
TRPV2 ion channel in partially closed state
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6bo5
Q-score: 0.358
Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG
Nat Struct Mol Biol (2019) 26 pp. 40-49 [ DOI: doi:10.1038/s41594-018-0168-8 Pubmed: 30598551 ]
Structural and functional impacts of ER coactivator sequential recruitment
Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW
Mol Cell (2017) 67 pp. 733-743.e4 [ DOI: doi:10.1016/j.molcel.2017.07.026 Pubmed: 28844863 ]
Structural and functional impacts of ER coactivator sequential recruitment
Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW
Mol Cell (2017) 67 pp. 733-743.e4 [ DOI: doi:10.1016/j.molcel.2017.07.026 Pubmed: 28844863 ]
Structural and functional impacts of ER coactivator sequential recruitment
Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW
Mol Cell (2017) 67 pp. 733-743.e4 [ DOI: doi:10.1016/j.molcel.2017.07.026 Pubmed: 28844863 ]