TRPV2 ion channel gating through allosteric domain coupling revealed by cryo-EM
Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG
Nat. Struct. Mol. Biol. (2018) 26 pp. 40-49 [ DOI: 10.1038/s41594-018-0168-8 Pubmed: 30598551 ]
Image sets:
Open state structure of the full-length TRPV2 cation channel with a resolved pore turret domain
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6bo4
Q-score: 0.347
Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG
Nat Struct Mol Biol (2019) 26 pp. 40-49 [ DOI: doi:10.1038/s41594-018-0168-8 Pubmed: 30598551 ]
- Transient receptor potential cation channel subfamily v member 2 (79 kDa, Protein from Rattus norvegicus)
- Trpv2 (320 kDa, Complex from Rattus norvegicus)
TRPV2 ion channel in partially closed state
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6bo5
Q-score: 0.358
Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG
Nat Struct Mol Biol (2019) 26 pp. 40-49 [ DOI: doi:10.1038/s41594-018-0168-8 Pubmed: 30598551 ]
Structural and functional impacts of ER coactivator sequential recruitment
Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW
Mol Cell (2017) 67 pp. 733-743.e4 [ DOI: doi:10.1016/j.molcel.2017.07.026 Pubmed: 28844863 ]
Structural and functional impacts of ER coactivator sequential recruitment
Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW
Mol Cell (2017) 67 pp. 733-743.e4 [ DOI: doi:10.1016/j.molcel.2017.07.026 Pubmed: 28844863 ]
Structural and functional impacts of ER coactivator sequential recruitment
Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW
Mol Cell (2017) 67 pp. 733-743.e4 [ DOI: doi:10.1016/j.molcel.2017.07.026 Pubmed: 28844863 ]
Asymmetric structure of AcrAB-TolC tripartite multi drug efflux pump
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 5o66
Q-score: 0.24
Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D
eLife (2017) 6 [ DOI: doi:10.7554/eLife.24905 Pubmed: 28355133 ]
- 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile (526 Da, Ligand)
- Outer membrane protein tolc (53 kDa, Protein from Escherichia coli (strain K12))
- Multidrug efflux pump accessory protein acrz (5 kDa, Protein from Escherichia coli (strain K12))
- Multidrug efflux pump subunit acra (39 kDa, Protein from Escherichia coli (strain K12))
- Acrabz-tolc (Complex from Escherichia coli K12)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli (strain K12))
multi-drug efflux; membrane transport; RND superfamily; Drug resistance
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 5ng5
Q-score: 0.326
Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D
eLife (2017) 6 [ DOI: doi:10.7554/eLife.24905 Pubmed: 28355133 ]
- Multidrug efflux pump accessory protein acrz (5 kDa, Protein from Escherichia coli)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli)
- Acrabtolc in apo state (Complex from Escherichia coli)
- 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile (526 Da, Ligand)
- Multidrug efflux pump subunit acra (39 kDa, Protein from Escherichia coli)
- Outer membrane protein tolc (53 kDa, Protein from Escherichia coli)
multi-drug efflux; membrane transport; RND superfamily; Drug resistance
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 5v5s
Q-score: 0.193
Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D
eLife (2017) 6 [ DOI: doi:10.7554/eLife.24905 Pubmed: 28355133 ]
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli )
- Multidrug efflux pump subunit acra (42 kDa, Protein from Escherichia coli)
- Acrabtolc in apo state (Complex from Escherichia coli)
- Outer membrane protein tolc (48 kDa, Protein from Escherichia coli)
Structure of full-length IP3R1 channel in the apo-state determined by single particle cryo-EM
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 3jav
Q-score: 0.219
Fan G, Baker ML, Wang Z, Baker MR, Sinyagovskiy PA, Chiu W, Ludtke SJ, Serysheva II
Nature (2015) 527 pp. 336-341 [ DOI: doi:10.1038/nature15249 Pubmed: 26458101 ]
- Inositol 1,4,5-trisphosphate receptor (300 kDa, Protein from Rattus norvegicus)
- Inositol 1,4,5-trisphosphate receptor, type 1 (1 MDa, Sample)