Cryo-EM structure of a Legionella effector complexed with actin and AMP
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8jo3
Q-score: 0.618
Wang T, Song X, Tan J, Xian W, Zhou X, Yu M, Wang X, Xu Y, Wu T, Yuan K, Ran Y, Yang B, Fan G, Liu X, Zhou Y, Zhu Y
Nature (2024) 631 pp. 393-401 [ DOI: doi:10.1038/s41586-024-07573-z Pubmed: 38776962 ]
- Substrate of the dot/icm secretion system (50 kDa, Protein from Legionella sainthelensi)
- Adenosine monophosphate (347 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Actin, alpha skeletal muscle (42 kDa, Protein from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- Cryo-em structure of a legionella effector complexed with actin and amp (Complex from Legionella sainthelensi)
Cryo-EM structure of a Legionella effector complexed with actin and ATP
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8jo4
Q-score: 0.51
Wang T, Song X, Tan J, Xian W, Zhou X, Yu M, Wang X, Xu Y, Wu T, Yuan K, Ran Y, Yang B, Fan G, Liu X, Zhou Y, Zhu Y
Nature (2024) 631 pp. 393-401 [ DOI: doi:10.1038/s41586-024-07573-z Pubmed: 38776962 ]
- Cryo-em structure of a legionella effector complexed with actin and atp (Complex from Legionella sainthelensi)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Actin, alpha skeletal muscle (42 kDa, Protein from Oryctolagus cuniculus)
- Substrate of the dot/icm secretion system (50 kDa, Protein from Legionella sainthelensi)
- Calcium ion (40 Da, Ligand)
Open state structure of the full-length TRPV2 cation channel with a resolved pore turret domain
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6bo4
Q-score: 0.347
Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG
Nat Struct Mol Biol (2019) 26 pp. 40-49 [ DOI: doi:10.1038/s41594-018-0168-8 Pubmed: 30598551 ]
- Transient receptor potential cation channel subfamily v member 2 (79 kDa, Protein from Rattus norvegicus)
- Trpv2 (320 kDa, Complex from Rattus norvegicus)
TRPV2 ion channel in partially closed state
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6bo5
Q-score: 0.358
Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG
Nat Struct Mol Biol (2019) 26 pp. 40-49 [ DOI: doi:10.1038/s41594-018-0168-8 Pubmed: 30598551 ]
Structure of full-length IP3R1 channel bound with Adenophostin A (composite)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6mu1
Q-score: 0.263
Fan G, Baker MR, Wang Z, Seryshev AB, Ludtke SJ, Baker ML, Serysheva II
Cell Res (2018) 28 pp. 1158-1170 [ DOI: doi:10.1038/s41422-018-0108-5 Pubmed: 30470765 ]
- Inositol 1,4,5-trisphosphate receptor type 1 (312 kDa, Protein from Rattus norvegicus)
- Adenophostin a (669 Da, Ligand)
- Inositol 1,4,5-trisphosphate receptor (1 MDa, Complex from Rattus norvegicus)
Structure of full-length IP3R1 channel in Apo-state (composite)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6mu2
Q-score: 0.31
Fan G, Baker MR, Wang Z, Seryshev AB, Ludtke SJ, Baker ML, Serysheva II
Cell Res (2018) 28 pp. 1158-1170 [ DOI: doi:10.1038/s41422-018-0108-5 Pubmed: 30470765 ]
- Inositol 1,4,5-trisphosphate receptor type 1 (313 kDa, Protein from Rattus norvegicus)
- Inositol 1,4,5-trisphosphate receptor (1 MDa, Complex from Rattus norvegicus)
Structure of full-length IP3R1 channel in ligand-bound state
Fan G, Baker MR, Wang Z, Seryshev AB, Ludtke SJ, Baker ML, Serysheva II
Cell Res (2018) 28 pp. 1158-1170 [ DOI: doi:10.1038/s41422-018-0108-5 Pubmed: 30470765 ]
Structure of full-length IP3R1 channel in Apo-state
Fan G, Baker MR, Wang Z, Seryshev AB, Ludtke SJ, Baker ML, Serysheva II
Cell Res (2018) 28 pp. 1158-1170 [ DOI: doi:10.1038/s41422-018-0108-5 Pubmed: 30470765 ]
Asymmetric structure of AcrAB-TolC tripartite multi drug efflux pump
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 5o66
Q-score: 0.24
Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D
eLife (2017) 6 [ DOI: doi:10.7554/eLife.24905 Pubmed: 28355133 ]
- 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile (526 Da, Ligand)
- Outer membrane protein tolc (53 kDa, Protein from Escherichia coli (strain K12))
- Multidrug efflux pump accessory protein acrz (5 kDa, Protein from Escherichia coli (strain K12))
- Multidrug efflux pump subunit acra (39 kDa, Protein from Escherichia coli (strain K12))
- Acrabz-tolc (Complex from Escherichia coli K12)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli (strain K12))
multi-drug efflux; membrane transport; RND superfamily; Drug resistance
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 5ng5
Q-score: 0.326
Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D
eLife (2017) 6 [ DOI: doi:10.7554/eLife.24905 Pubmed: 28355133 ]
- Multidrug efflux pump accessory protein acrz (5 kDa, Protein from Escherichia coli)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli)
- Acrabtolc in apo state (Complex from Escherichia coli)
- 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile (526 Da, Ligand)
- Multidrug efflux pump subunit acra (39 kDa, Protein from Escherichia coli)
- Outer membrane protein tolc (53 kDa, Protein from Escherichia coli)