Cryo-EM structure of the g1:Ox-bound human GLP-1R-Gs complex
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 9j1p
Q-score: 0.505
Fan S, Li J, Zhuang J, Zhou Q, Mai Y, Lin B, Wang MW, Wu C
J Am Chem Soc (2025) 147 pp. 4821-4832 [ Pubmed: 39688263 DOI: doi:10.1021/jacs.4c12808 ]
- G1:ox (5 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of the g1 ox-bound human glp-1r-gs complex (Complex from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas (41 kDa, Protein from Homo sapiens)
Full-length cross-linked Contactin 2 (CNTN2)
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 9ba4
Q-score: 0.223
Fan S, Liu J, Chofflet N, Bailey AO, Russell WK, Zhang Z, Takahashi H, Ren G, Rudenko G
Structure (2024) 32 pp. 1652-1666.e8 [ DOI: doi:10.1016/j.str.2024.06.004 Pubmed: 38968938 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Contactin-2 (108 kDa, Protein from Homo sapiens)
- Contactin-2 full length (ig1-fn4) (Cellular component from Homo sapiens)
Cross-linked Contactin 2 Ig1-Ig6
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 9ba5
Q-score: 0.281
Fan S, Liu J, Chofflet N, Bailey AO, Russell WK, Zhang Z, Takahashi H, Ren G, Rudenko G
Structure (2024) 32 pp. 1652-1666.e8 [ DOI: doi:10.1016/j.str.2024.06.004 Pubmed: 38968938 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Contactin 2 ig1-ig6 (Cellular component from Homo sapiens)
- Contactin-2 (65 kDa, Protein from Homo sapiens)
Full-length cross-linked Contactin 2 (FN1 apart)
Fan S, Liu J, Chofflet N, Bailey AO, Russell WK, Zhang Z, Takahashi H, Ren G, Rudenko G
Structure (2024) 32 pp. 1652-1666.e8 [ DOI: doi:10.1016/j.str.2024.06.004 Pubmed: 38968938 ]
Cryo-EM structure of a Zinc-loaded wild-type YiiP-Fab complex
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8f6e
Q-score: 0.412
Hussein A, Fan S, Lopez-Redondo M, Kenney I, Zhang X, Beckstein O, Stokes DL
eLife (2023) 12 [ DOI: doi:10.7554/eLife.87167 Pubmed: 37906094 ]
- Wild-type zinc-loaded yiip-fab complex (163 kDa, Complex from Shewanella oneidensis)
- Zinc ion (65 Da, Ligand)
- Fab heavy chain (25 kDa, Protein from Homo sapiens)
- Cadmium and zinc efflux pump fief (32 kDa, Protein from Shewanella oneidensis)
- Fab light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of a Zinc-loaded D51A mutant of the YiiP-Fab complex
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8f6f
Q-score: 0.448
Hussein A, Fan S, Lopez-Redondo M, Kenney I, Zhang X, Beckstein O, Stokes DL
eLife (2023) 12 [ DOI: doi:10.7554/eLife.87167 Pubmed: 37906094 ]
- Zinc ion (65 Da, Ligand)
- Cadmium and zinc efflux pump fief (32 kDa, Protein from Shewanella oneidensis)
- D51a zinc-loaded yiip-fab complex (163 kDa, Complex from Shewanella oneidensis)
- Fab2r heavy chain (25 kDa, Protein from Homo sapiens)
- Fab2r light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of a Zinc-loaded asymmetrical TMD D70A mutant of the YiiP-Fab complex
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8f6h
Q-score: 0.419
Hussein A, Fan S, Lopez-Redondo M, Kenney I, Zhang X, Beckstein O, Stokes DL
eLife (2023) 12 [ DOI: doi:10.7554/eLife.87167 Pubmed: 37906094 ]
- Zinc ion (65 Da, Ligand)
- D70a asymmetrical zinc-loaded yiip-fab complex (163 kDa, Complex from Shewanella oneidensis)
- Cadmium and zinc efflux pump fief (32 kDa, Protein from Shewanella oneidensis MR-1)
- Fab2r heavy chain (25 kDa, Protein from Homo sapiens)
- Fab2r light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of a Zinc-loaded symmetrical D70A mutant of the YiiP-Fab complex
Resolution: 4.03 Å
EM Method: Single-particle
Fitted PDBs: 8f6i
Q-score: 0.388
Hussein A, Fan S, Lopez-Redondo M, Kenney I, Zhang X, Beckstein O, Stokes DL
eLife (2023) 12 [ DOI: doi:10.7554/eLife.87167 Pubmed: 37906094 ]
- Zinc ion (65 Da, Ligand)
- Cadmium and zinc efflux pump fief (32 kDa, Protein from Shewanella oneidensis MR-1)
- Fab2r heavy chain (25 kDa, Protein from Homo sapiens)
- D70a symmetrical zinc-loaded yiip-fab complex (163 kDa, Complex from Shewanella oneidensis)
- Fab2r light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of a Zinc-loaded D287A mutant of the YiiP-Fab complex
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8f6j
Q-score: 0.408
Hussein A, Fan S, Lopez-Redondo M, Kenney I, Zhang X, Beckstein O, Stokes DL
eLife (2023) 12 [ DOI: doi:10.7554/eLife.87167 Pubmed: 37906094 ]
- D287a zinc-loaded yiip-fab complex (163 kDa, Complex from Shewanella oneidensis)
- Cadmium and zinc efflux pump fief (32 kDa, Protein from Shewanella oneidensis)
- Zinc ion (65 Da, Ligand)
- Fab2r heavy chain (25 kDa, Protein from Homo sapiens)
- Fab2r light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of a Zinc-loaded H263A/D287A mutant of the YiiP-Fab complex
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 8f6k
Q-score: 0.433
Hussein A, Fan S, Lopez-Redondo M, Kenney I, Zhang X, Beckstein O, Stokes DL
eLife (2023) 12 [ DOI: doi:10.7554/eLife.87167 Pubmed: 37906094 ]
- D287a_h263a zinc-loaded yiip-fab complex (325 kDa, Complex from Shewanella oneidensis)
- Cadmium and zinc efflux pump fief (32 kDa, Protein from Shewanella oneidensis)
- Zinc ion (65 Da, Ligand)