Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7s0q
Q-score: 0.328
Xu Y, Margetts MB, Venugopal H, Menting JG, Kirk NS, Croll TI, Delaine C, Forbes BE, Lawrence MC
Structure (2022) 30 pp. 1098-1108.e6 [ Pubmed: 35660159 DOI: doi:10.1016/j.str.2022.05.007 ]
- Beta-d-mannopyranose (180 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- A complex of igf-i with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor (250 MDa, Complex from Homo sapiens)
- Insulin-like growth factor i (7 kDa, Protein from Homo sapiens)
- Insulin receptor (109 kDa, Protein from Homo sapiens)
- Insulin-like growth factor 1 receptor (108 kDa, Protein from Homo sapiens)
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 7s8v
Q-score: 0.232
Xu Y, Margetts MB, Venugopal H, Menting JG, Kirk NS, Croll TI, Delaine C, Forbes BE, Lawrence MC
Structure (2022) 30 pp. 1098-1108.e6 [ Pubmed: 35660159 DOI: doi:10.1016/j.str.2022.05.007 ]
- A complex of igf-i with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor (250 MDa, Complex from Homo sapiens)
- Insulin-like growth factor 1 receptor (108 kDa, Protein from Homo sapiens)
- Insulin receptor (109 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
The insulin receptor ectodomain in complex with a venom hybrid insulin analog - "head" region
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7mqo
Q-score: 0.44
Xiong X, Blakely A, Kim JH, Menting JG, Schafer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun U, Fisher SJ, Forbes BE, Safavi-Hemami H, Hill CP, Chou DH
Nat Chem Biol (2022) 18 pp. 511-519 [ DOI: doi:10.1038/s41589-022-00981-0 Pubmed: 35289328 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Isoform short of insulin receptor (104 kDa, Protein from Homo sapiens)
- Insulin receptor ectodomain in complex with insulin analog vh-ins-hslq - focused refinement. (209 kDa, Complex from Homo sapiens)
- Insulin b chain (2 kDa, Protein from Homo sapiens)
The insulin receptor ectodomain in complex with four venom hybrid insulins - symmetric conformation
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7mqr
Q-score: 0.304
Xiong X, Blakely A, Kim JH, Menting JG, Schafer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun U, Fisher SJ, Forbes BE, Safavi-Hemami H, Hill CP, Chou DH
Nat Chem Biol (2022) 18 pp. 511-519 [ DOI: doi:10.1038/s41589-022-00981-0 Pubmed: 35289328 ]
- Isoform short of insulin receptor (104 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Insulin receptor ectodomain in complex with insulin analog vh-ins-hslq - whole ectodomain. (209 kDa, Complex from Homo sapiens)
- Insulin b chain (2 kDa, Protein from Homo sapiens)
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7mqs
Q-score: 0.232
Xiong X, Blakely A, Kim JH, Menting JG, Schafer IB, Schubert HL, Agrawal R, Gutmann T, Delaine C, Zhang YW, Artik GO, Merriman A, Eckert D, Lawrence MC, Coskun U, Fisher SJ, Forbes BE, Safavi-Hemami H, Hill CP, Chou DH
Nat Chem Biol (2022) 18 pp. 511-519 [ DOI: doi:10.1038/s41589-022-00981-0 Pubmed: 35289328 ]
- Isoform short of insulin receptor (104 kDa, Protein from Homo sapiens)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Insulin receptor ectodomain in complex with insulin analog vh-ins-hslq - asymmetric conformation. (209 kDa, Complex from Homo sapiens)
- Insulin b chain (2 kDa, Protein from Homo sapiens)
Forbes BE, Safavi-Hemami H, Hill CP, Chou DH
Nat Chem Biol (2022) 18 pp. 511-519 [ DOI: 10.1038/s41589-022-00981-0 Pubmed: 35289328 ]
Image sets:
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 6vwg
Q-score: 0.453
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC
Structure (2020) 28 pp. 786-798.e6 [ DOI: doi:10.1016/j.str.2020.05.002 Pubmed: 32459985 ]
- Insulin-like growth factor ii (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin-like growth factor ii (7 kDa, Protein from Homo sapiens)
- Head region of the open-leg conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii. (250 kDa, Complex from Homo sapiens)
- Insulin-like growth factor 1 receptor (Complex from Homo sapiens)
- Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (108 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Resolution: 4.26 Å
EM Method: Single-particle
Fitted PDBs: 6vwh
Q-score: 0.207
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC
Structure (2020) 28 pp. 786-798.e6 [ DOI: doi:10.1016/j.str.2020.05.002 Pubmed: 32459985 ]
- Leg region of the open-leg conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii. (250 kDa, Complex from Homo sapiens)
- Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (108 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6vwi
Q-score: 0.407
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC
Structure (2020) 28 pp. 786-798.e6 [ DOI: doi:10.1016/j.str.2020.05.002 Pubmed: 32459985 ]
- Insulin-like growth factor ii (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin-like growth factor ii (7 kDa, Protein from Homo sapiens)
- Head region of the close-leg conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii. (250 kDa, Complex from Homo sapiens)
- Insulin-like growth factor 1 receptor (Complex from Homo sapiens)
- Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (108 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Resolution: 4.21 Å
EM Method: Single-particle
Fitted PDBs: 6vwj
Q-score: 0.245
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC
Structure (2020) 28 pp. 786-798.e6 [ DOI: doi:10.1016/j.str.2020.05.002 Pubmed: 32459985 ]
- Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (108 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Leg region of the open-leg conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii (250 kDa, Complex from Homo sapiens)