human MutSalpha (MSH2/MSH6) binding to DNA with a GT mismatch
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8ag6
Q-score: 0.542
Bruekner SR, Pieters W, Fish A, Liaci AM, Scheffers S, Rayner E, Kaldenbach D, Drost L, Dekker M, van Hees-Stuivenberg S, Delzenne-Goette E, de Konink C, Houlleberghs H, Dubbink HJ, AlSaegh A, de Wind N, Forster F, Te Riele H, Sixma TK
Nucleic Acids Res (2023) 51 pp. 1173-1188 [ Pubmed: 36715327 DOI: doi:10.1093/nar/gkad015 ]
- Magnesium ion (24 Da, Ligand)
- Dna containing a g/t mismatch (Complex from Homo sapiens)
- Msh2 (Complex from Homo sapiens)
- Dna mismatch repair protein msh6 (158 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Msh6 (Complex from Homo sapiens)
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
- Dna (50-mer) (15 kDa, DNA from synthetic construct)
- Mutsalpha on mismatched dna (31 kDa, Complex from Homo sapiens)
- Dna (50-mer) (15 kDa, DNA from synthetic construct)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7akd
Q-score: 0.413
Fedry J, Hurdiss DL, Wang C, Li W, Obal G, Drulyte I, Du W, Howes SC, van Kuppeveld FJM, Forster F, Bosch BJ
Sci Adv (2021) 7 [ DOI: doi:10.1126/sciadv.abf5632 Pubmed: 33958322 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Alpha-l-fucopyranose (164 Da, Ligand)
- 47d11 neutralizing antibody light chain (11 kDa, Protein from Homo sapiens)
- 47d11 neutralizing antibody heavy chain (13 kDa, Protein from Homo sapiens)
- Complex of the sars-cov-2 spike glycoprotein with the 47d11 neutralizing antibody fab fragment (550 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
human STEAP4 bound to NADP, FAD, heme and Fe(III)-NTA.
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6hcy
Q-score: 0.549
Oosterheert W, van Bezouwen LS, Rodenburg RNP, Granneman J, Forster F, Mattevi A, Gros P
Nat Commun (2018) 9 pp. 4337-4337 [ DOI: doi:10.1038/s41467-018-06817-7 Pubmed: 30337524 ]
- Metalloreductase steap4 (52 kDa, Protein from Homo sapiens)
- Nadp nicotinamide-adenine-dinucleotide phosphate (743 Da, Ligand)
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human six-transmembrane epithelial antigen of the prostate 4 (152 kDa, Complex from Homo sapiens)
human STEAP4 bound to NADPH, FAD and heme.
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6hd1
Q-score: 0.435
Oosterheert W, van Bezouwen LS, Rodenburg RNP, Granneman J, Forster F, Mattevi A, Gros P
Nat Commun (2018) 9 pp. 4337-4337 [ DOI: doi:10.1038/s41467-018-06817-7 Pubmed: 30337524 ]
- Metalloreductase steap4 (52 kDa, Protein from Homo sapiens)
- Nadp nicotinamide-adenine-dinucleotide phosphate (743 Da, Ligand)
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Homotrimer of human steap4. (152 kDa, Complex from Homo sapiens)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
26S proteasome in presence of ATP (s1)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 5mp9, 5mpd
Q-score: 0.2815
Wehmer M, Rudack T, Beck F, Aufderheide A, Pfeifer G, Plitzko JM, Forster F, Schulten K, Baumeister W, Sakata E
PNAS (2017) 114 pp. 1305-1310 [ Pubmed: 28115689 DOI: doi:10.1073/pnas.1621129114 ]
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-7 (29 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 7 homolog (52 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Proteasome subunit beta type-2 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 8 homolog (45 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 4 homolog (48 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Magnesium ion (24 Da, Ligand)
- 26s protease regulatory subunit 6a (48 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome of saccharomyces cerevisiae in presence of atp (s1) (1 MDa, Complex from Saccharomyces cerevisiae S288c)
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-1 (23 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Probable proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-6 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-5 (31 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease subunit rpt4 (49 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-3 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 6b homolog (47 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
26S proteasome in presence of ATP (s2)
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 5mpa, 5mpe
Q-score: 0.2305
Wehmer M, Rudack T, Beck F, Aufderheide A, Pfeifer G, Plitzko JM, Forster F, Schulten K, Baumeister W, Sakata E
PNAS (2017) 114 pp. 1305-1310 [ Pubmed: 28115689 DOI: doi:10.1073/pnas.1621129114 ]
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-7 (29 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 7 homolog (52 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Proteasome subunit beta type-2 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 8 homolog (45 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 4 homolog (48 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Magnesium ion (24 Da, Ligand)
- 26s protease regulatory subunit 6a (48 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome of saccharomyces cerevisiae in presence of atp (s2) (1 MDa, Complex from Saccharomyces cerevisiae S288c)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-1 (23 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Probable proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-6 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-5 (31 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease subunit rpt4 (49 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-3 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 6b homolog (47 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
26S proteasome in presence of AMP-PNP (s3)
Resolution: 7.8 Å
EM Method: Single-particle
Fitted PDBs: 5mpb
Q-score: 0.132
Wehmer M, Rudack T, Beck F, Aufderheide A, Pfeifer G, Plitzko JM, Forster F, Schulten K, Baumeister W, Sakata E
PNAS (2017) 114 pp. 1305-1310 [ Pubmed: 28115689 DOI: doi:10.1073/pnas.1621129114 ]
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn12 (31 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-7 (29 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 7 homolog (52 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Proteasome subunit beta type-2 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn8 (38 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 8 homolog (45 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Ubiquitin carboxyl-terminal hydrolase rpn11 (34 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn5 (51 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 4 homolog (48 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn10 (29 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Magnesium ion (24 Da, Ligand)
- 26s proteasome regulatory subunit rpn13 (17 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 6a (48 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome complex subunit sem1 (10 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn2 (104 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome of saccharomyces cerevisiae in presence of amp-pnp (1 MDa, Complex from Saccharomyces cerevisiae S288c)
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn7 (49 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-1 (23 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn9 (45 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Probable proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn6 (49 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn1 (109 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-6 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-5 (31 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease subunit rpt4 (49 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-3 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn3 (60 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 6b homolog (47 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
26S proteasome in presence of BeFx (s4)
Resolution: 7.7 Å
EM Method: Single-particle
Fitted PDBs: 5mpc
Q-score: 0.135
Wehmer M, Rudack T, Beck F, Aufderheide A, Pfeifer G, Plitzko JM, Forster F, Schulten K, Baumeister W, Sakata E
PNAS (2017) 114 pp. 1305-1310 [ Pubmed: 28115689 DOI: doi:10.1073/pnas.1621129114 ]
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn12 (31 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-7 (29 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 7 homolog (52 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Proteasome subunit beta type-2 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn8 (38 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 8 homolog (45 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Ubiquitin carboxyl-terminal hydrolase rpn11 (34 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn5 (51 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 4 homolog (48 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn10 (29 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Magnesium ion (24 Da, Ligand)
- 26s proteasome regulatory subunit rpn13 (17 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 6a (48 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome of saccharomyces cerevisiae in presence of befx (s4) (1 MDa, Complex from Saccharomyces cerevisiae S288c)
- 26s proteasome complex subunit sem1 (10 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn2 (104 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn7 (49 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Ubiquitin carboxyl-terminal hydrolase 6 (57 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-1 (23 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn9 (45 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Probable proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn6 (49 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn1 (109 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-6 (26 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit beta type-5 (31 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease subunit rpt4 (49 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Proteasome subunit alpha type-3 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s proteasome regulatory subunit rpn3 (60 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 26s protease regulatory subunit 6b homolog (47 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))