TRPV1 in nanodisc bound with PI-Br4 bound in Conformation 1 (monomer)
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 8u3a
Q-score: 0.671
Arnold WR, Mancino A, Moss 3rd FR, Frost A, Julius D, Cheng Y
Nat Struct Mol Biol (2024) 31 pp. 1377-1385 [ DOI: doi:10.1038/s41594-024-01299-2 Pubmed: 38698206 ]
- Water (18 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Trpv1 in nanodisc bound with pi-br4 in conformation 1 (monomer) (688 kDa, Complex from Rattus norvegicus)
- Sodium ion (22 Da, Ligand)
- (2s)-2-[(9,10-dibromooctadecanoyl)oxy]-3-{[(s)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9r,10s)-9,10-dibromooctadecanoate (1 kDa, Ligand)
- Transient receptor potential cation channel subfamily v member 1 (72 kDa, Protein from Rattus norvegicus)
TRPV1 in nanodisc bound with PI-Br4 bound in Conformation 2 (monomer)
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 8u3c
Q-score: 0.649
Arnold WR, Mancino A, Moss 3rd FR, Frost A, Julius D, Cheng Y
Nat Struct Mol Biol (2024) 31 pp. 1377-1385 [ DOI: doi:10.1038/s41594-024-01299-2 Pubmed: 38698206 ]
- Trpv1 in nanodisc bound with pi-br4 in conformation 2 (monomer) (688 kDa, Complex from Rattus norvegicus)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- (2s)-2-[(9,10-dibromooctadecanoyl)oxy]-3-{[(s)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9r,10s)-9,10-dibromooctadecanoate (1 kDa, Ligand)
- Transient receptor potential cation channel subfamily v member 1 (92 kDa, Protein from Rattus norvegicus)
- Water (18 Da, Ligand)
TRPV1 in nanodisc bound with empty vanilloid binding pocket at 4C
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8u3j
Q-score: 0.497
Arnold WR, Mancino A, Moss 3rd FR, Frost A, Julius D, Cheng Y
Nat Struct Mol Biol (2024) 31 pp. 1377-1385 [ DOI: doi:10.1038/s41594-024-01299-2 Pubmed: 38698206 ]
- Transient receptor potential cation channel subfamily v member 1 (61 kDa, Protein from Rattus norvegicus)
- Trpv1 in nanodisc with empty vanilloid binding pocket at 4c (688 kDa, Complex from Rattus norvegicus)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Water (18 Da, Ligand)
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8tu6
Q-score: 0.525
Varkaris A, Pazolli E, Gunaydin H, Wang Q, Pierce L, Boezio AA, Bulku A, DiPietro L, Fridrich C, Frost A, Giordanetto F, Hamilton EP, Harris K, Holliday M, Hunter TL, Iskandar A, Ji Y, Larivee A, LaRochelle JR, Lescarbeau A, Llambi F, Lormil B, Mader MM, Mar BG, Martin I, McLean TH, Michelsen K, Pechersky Y, Puente-Poushnejad E, Raynor K, Rogala D, Samadani R, Schram AM, Shortsleeves K, Swaminathan S, Tajmir S, Tan G, Tang Y, Valverde R, Wehrenberg B, Wilbur J, Williams BR, Zeng H, Zhang H, Walters WP, Wolf BB, Shaw DE, Bergstrom DA, Watters J, Fraser JS, Fortin PD, Kipp DR
Cancer Discov (2024) 14 pp. 240-257 [ Pubmed: 37916956 DOI: doi:10.1158/2159-8290.CD-23-0944 ]
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (126 kDa, Protein from Homo sapiens)
- P110 (Complex from Homo sapiens)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- P85 (Complex from Homo sapiens)
- Pi3kalpha (850 kDa, Complex from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7ssp
Q-score: 0.481
Manicki M, Aydin H, Abriata LA, Overmyer KA, Guerra RM, Coon JJ, Dal Peraro M, Frost A, Pagliarini DJ
Mol Cell (2022) 82 pp. 4307-4323.e10 [ Pubmed: 36306796 DOI: doi:10.1016/j.molcel.2022.10.003 ]
- Ubiquinone biosynthesis protein coq9, mitochondrial (35 kDa, Protein from Homo sapiens)
- 5-demethoxyubiquinone hydroxylase, mitochondrial (24 kDa, Protein from Homo sapiens)
- Human coq7:coq9 complex (Complex from Homo sapiens)