CHMP1B/IST1 ssRNA bound copolymer
Resolution: 2.95 Å
EM Method: Helical reconstruction
Fitted PDBs: 8v2q
Q-score: 0.568
Talledge N, Glover J, McCullough J, Alian A, Sadler JBA, Dempsey N, Laughlin TG, Nguyen HC, Wenzel D, Lalonde MS, Ventimiglia LN, LaJoie D, Iwasa J, Starling T, Padilla-Parra S, Ullman KS, Frost A, Sundquist WI, Martin-Serrano J
To Be Published
- Ist1 homolog (39 kDa, Protein from Homo sapiens)
- Chmp1b/ist1 copolymer bound to a 60-mer oligonucleotide of ssrna (397 kDa, Complex from Homo sapiens)
- Ist1 (Complex from Homo sapiens)
- Charged multivesicular body protein 1b (chmp1b) (Complex from Homo sapiens)
- Charged multivesicular body protein 1b (22 kDa, Protein from Homo sapiens)
CryoEM of ssDNA bound CHMP1B/IST1 copolymer assembly
Resolution: 3.01 Å
EM Method: Helical reconstruction
Fitted PDBs: 8v2r
Q-score: 0.551
Talledge N, Glover J, McCullough J, Alian A, Sadler JBA, Dempsey N, Laughlin TG, Nguyen HC, Wenzel D, Lalonde MS, Ventimiglia LN, LaJoie D, Iwasa J, Starling T, Padilla-Parra S, Ullman KS, Frost A, Sundquist WI, Martin-Serrano J
To Be Published
- Ist1 homolog (39 kDa, Protein from Homo sapiens)
- Chmp1b/ist1 copolymer bound to a 60-mer oligonucleotide of ssdna (397 kDa, Complex from Homo sapiens)
- Ist1 (Complex from Homo sapiens)
- Charged multivesicular body protein 1b (chmp1b) (Complex from Homo sapiens)
- Charged multivesicular body protein 1b (22 kDa, Protein from Homo sapiens)
CHMP1B/IST1 dsDNA bound copolymer
Resolution: 2.72 Å
EM Method: Helical reconstruction
Fitted PDBs: 8v2s
Q-score: 0.6
Talledge N, Glover J, McCullough J, Alian A, Sadler JBA, Dempsey N, Laughlin TG, Nguyen HC, Wenzel D, Lalonde MS, Ventimiglia LN, LaJoie D, Iwasa J, Starling T, Padilla-Parra S, Ullman KS, Frost A, Sundquist WI, Martin-Serrano J
To Be Published
- Ist1 homolog (39 kDa, Protein from Homo sapiens)
- Chmp1b/ist1 copolymer bound to a 60-mer oligonucleotide of ssdna (397 kDa, Complex from Homo sapiens)
- Increased sodium tolerance 1 (ist1) (Complex from Homo sapiens)
- Charged multivesicular body protein 1b (chmp1b) (Complex from Homo sapiens)
- Charged multivesicular body protein 1b (22 kDa, Protein from Homo sapiens)
TRPV1 in Nanodisc bound with lysophosphatidic acid in all four monomers
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8t0c
Q-score: 0.457
Arnold WR, Mancino A, Moss 3rd FR, Frost A, Julius D, Cheng Y
Nat Struct Mol Biol (2024) 31 pp. 1377-1385 [ DOI: doi:10.1038/s41594-024-01299-2 Pubmed: 38698206 ]
- (2r)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate (382 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 1 (92 kDa, Protein from Rattus norvegicus)
- Trpv1 in nanodisc bound with lysophosphatidic acid in all four monomers (688 kDa, Complex from Rattus norvegicus)
- Sodium ion (22 Da, Ligand)
TRPV1 in Nanodisc not bound with lysophosphatidic acid (apo)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8t0e
Q-score: 0.462
Arnold WR, Mancino A, Moss 3rd FR, Frost A, Julius D, Cheng Y
Nat Struct Mol Biol (2024) 31 pp. 1377-1385 [ DOI: doi:10.1038/s41594-024-01299-2 Pubmed: 38698206 ]
- Sodium ion (22 Da, Ligand)
- (2r)-3-{[(r)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate (867 Da, Ligand)
- Trpv1 in nanodisc, no lysophosphatidic acid bound (688 kDa, Complex from Rattus norvegicus)
- Transient receptor potential cation channel subfamily v member 1 (92 kDa, Protein from Rattus norvegicus)
- Water (18 Da, Ligand)
TRPV1 in nanodisc bound with one LPA in one monomer
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8t0y
Q-score: 0.471
Arnold WR, Mancino A, Moss 3rd FR, Frost A, Julius D, Cheng Y
Nat Struct Mol Biol (2024) 31 pp. 1377-1385 [ DOI: doi:10.1038/s41594-024-01299-2 Pubmed: 38698206 ]
- (2r)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate (382 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- (2r)-3-{[(r)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate (867 Da, Ligand)
- Trpv1 in nanodisc bound with one lpa in one monomer (688 kDa, Complex from Rattus norvegicus)
- Transient receptor potential cation channel subfamily v member 1 (92 kDa, Protein from Rattus norvegicus)
TRPV1 in nanodisc bound with two LPA molecules in opposite monomers
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8t10
Q-score: 0.392
Arnold WR, Mancino A, Moss 3rd FR, Frost A, Julius D, Cheng Y
Nat Struct Mol Biol (2024) 31 pp. 1377-1385 [ DOI: doi:10.1038/s41594-024-01299-2 Pubmed: 38698206 ]
- (2r)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate (382 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- (2r)-3-{[(r)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate (867 Da, Ligand)
- Trpv1 in nanodisc bound with two lpa molecules in opposite monomers (688 kDa, Complex from Rattus norvegicus)
- Transient receptor potential cation channel subfamily v member 1 (92 kDa, Protein from Rattus norvegicus)
TRPV1 in nanodisc bound with 2 LPA molecules in neighboring monomers
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8t3l
Q-score: 0.47
Arnold WR, Mancino A, Moss 3rd FR, Frost A, Julius D, Cheng Y
Nat Struct Mol Biol (2024) 31 pp. 1377-1385 [ DOI: doi:10.1038/s41594-024-01299-2 Pubmed: 38698206 ]
- (2r)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate (382 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 1 (73 kDa, Protein from Rattus norvegicus)
- (2r)-3-{[(r)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate (867 Da, Ligand)
- Trpv1 in nanodisc bound with 2 lpa molecules in neighboring monomers (688 kDa, Complex from Rattus norvegicus)
TRPV1 in nanodisc bound with 3 LPA molecules
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8t3m
Q-score: 0.447
Arnold WR, Mancino A, Moss 3rd FR, Frost A, Julius D, Cheng Y
Nat Struct Mol Biol (2024) 31 pp. 1377-1385 [ DOI: doi:10.1038/s41594-024-01299-2 Pubmed: 38698206 ]
- (2r)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate (382 Da, Ligand)
- [(2~{r})-2-hexadecanoyloxy-3-[oxidanyl-[(2~{s},3~{s},5~{r},6~{s})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propyl] hexadecanoate (811 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 1 (73 kDa, Protein from Rattus norvegicus)
- Trpv1 in nanodisc bound with 2 lpa molecules in neighboring monomers (688 kDa, Complex from Rattus norvegicus)
TRPV1 in nanodisc bound with diC8-PIP2 in the dilated state
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8u2z
Q-score: 0.447
Arnold WR, Mancino A, Moss 3rd FR, Frost A, Julius D, Cheng Y
Nat Struct Mol Biol (2024) 31 pp. 1377-1385 [ DOI: doi:10.1038/s41594-024-01299-2 Pubmed: 38698206 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Water (18 Da, Ligand)
- Trpv1 in nanodisc bound with dic8-pip2 in the dilated state (688 kDa, Complex from Rattus norvegicus)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 1 (72 kDa, Protein from Rattus norvegicus)