S728-1157 IgG in complex with SARS-CoV-2-6P-Mut7 Spike protein (global refinement)
Changrob S, Halfmann PJ, Liu H, Torres JL, McGrath JJC, Ozorowski G, Li L, Wilbanks GD, Kuroda M, Maemura T, Huang M, Zheng NY, Turner HL, Erickson SA, Fu Y, Yasuhara A, Singh G, Monahan B, Mauldin J, Srivastava K, Simon V, Krammer F, Sather DN, Ward AB, Wilson IA, Kawaoka Y, Wilson PC
J Clin Inv (2023) 133 [ DOI: doi:10.1172/JCI166844 Pubmed: 36862518 ]
S728-1157 IgG in complex with SARS-CoV-2-6P-Mut7 Spike protein (focused refinement)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8d0z
Q-score: 0.42
Changrob S, Halfmann PJ, Liu H, Torres JL, McGrath JJC, Ozorowski G, Li L, Wilbanks GD, Kuroda M, Maemura T, Huang M, Zheng NY, Turner HL, Erickson SA, Fu Y, Yasuhara A, Singh G, Monahan B, Mauldin J, Srivastava K, Simon V, Krammer F, Sather DN, Ward AB, Wilson IA, Kawaoka Y, Wilson PC
J Clin Inv (2023) 133 [ DOI: doi:10.1172/JCI166844 Pubmed: 36862518 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- S728-1157 fab heavy chain variable region (12 kDa, Protein from Homo sapiens)
- S728-1157 fab light chain variable region (11 kDa, Protein from Homo sapiens)
- S728-1157 igg in complex with sars-cov-2-6p-mut7 s protein (Complex from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of CopC-CaM-caspase-3 with NAD+
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 7xn4
Q-score: 0.492
Zhang K, Peng T, Tao X, Tian M, Li Y, Wang Z, Ma S, Hu S, Pan X, Xue J, Luo J, Wu Q, Fu Y, Li S
Mol Cell (2022) 82 pp. 4712-4726.e7 [ Pubmed: 36423631 DOI: doi:10.1016/j.molcel.2022.10.032 ]
- Cryo-em structure of copc-cam-caspase-3 with nad+ (Complex from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Nicotinamide-adenine-dinucleotide (663 Da, Ligand)
- Arginine adp-riboxanase copc (52 kDa, Protein from Chromobacterium violaceum)
- Caspase-3 (31 kDa, Protein from Homo sapiens)
Cryo-EM structure of CopC-CaM-caspase-3 with ADPR
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 7xn5
Q-score: 0.517
Zhang K, Peng T, Tao X, Tian M, Li Y, Wang Z, Ma S, Hu S, Pan X, Xue J, Luo J, Wu Q, Fu Y, Li S
Mol Cell (2022) 82 pp. 4712-4726.e7 [ Pubmed: 36423631 DOI: doi:10.1016/j.molcel.2022.10.032 ]
- Nicotinamide (122 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Cryo-em structure of copc-cam-caspase-3 with adpr (Complex from Homo sapiens)
- Arginine adp-riboxanase copc (52 kDa, Protein from Chromobacterium violaceum)
- Caspase-3 (31 kDa, Protein from Homo sapiens)
- Adenosine-5-diphosphoribose (559 Da, Ligand)
Cryo-EM structure of CopC-CaM-caspase-3 with ADPR-deacylization
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 7xn6
Q-score: 0.466
Zhang K, Peng T, Tao X, Tian M, Li Y, Wang Z, Ma S, Hu S, Pan X, Xue J, Luo J, Wu Q, Fu Y, Li S
Mol Cell (2022) 82 pp. 4712-4726.e7 [ Pubmed: 36423631 DOI: doi:10.1016/j.molcel.2022.10.032 ]
- Nicotinamide (122 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Caspase-3 (32 kDa, Protein from Homo sapiens)
- Arginine adp-riboxanase copc (52 kDa, Protein from Chromobacterium violaceum)
- Cryo-em structure of copc-cam-caspase-3 with adpr-deacylization (Complex from Homo sapiens)
Cryo-EM Structure of the Lysosomal Folliculin Complex (FLCN-FNIP2-RagA-RagC-Ragulator)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6nzd
Q-score: 0.326
Lawrence RE, Fromm SA, Fu Y, Yokom AL, Kim DJ, Thelen AM, Young LN, Lim CY, Samelson AJ, Hurley JH, Zoncu R
Science (2019) 366 pp. 971-977 [ Pubmed: 31672913 DOI: doi:10.1126/science.aax0364 ]
- 9-{5-o-[(s)-hydroxy{[(r)-hydroxy(thiophosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-l-arabinofuranosyl}-3,9-dihydro-1h-purine-2,6-dione (540 Da, Ligand)
- Ragulator complex protein lamtor2 (13 kDa, Protein from Homo sapiens)
- Ras-related gtp-binding protein c (44 kDa, Protein from Homo sapiens)
- Ragulator complex protein lamtor1 (18 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Hepatitis b virus x interacting protein (18 kDa, Protein from Homo sapiens)
- Folliculin (69 kDa, Protein from Homo sapiens)
- Ragulator complex protein lamtor4 (10 kDa, Protein from Homo sapiens)
- Folliculin-interacting protein 2 (122 kDa, Protein from Homo sapiens)
- Ragulator complex protein lamtor3 (13 kDa, Protein from Homo sapiens)
- Flcn-fnip2-raga-ragc-ragulator complex (340 kDa, Complex from Homo sapiens)
- Ras-related gtp-binding protein a (36 kDa, Protein from Homo sapiens)
Cryo-EM Map of the active Ragulator-RagA-RagC Complex
Lawrence RE, Fromm SA, Fu Y, Yokom AL, Kim DJ, Thelen AM, Young LN, Lim CY, Samelson AJ, Hurley JH, Zoncu R
Science (2019) 366 pp. 971-977 [ Pubmed: 31672913 DOI: doi:10.1126/science.aax0364 ]
- Active raga-ragc-ragulator complex (150 kDa, Complex from Homo sapiens)
