Cryo-EM structure of HCA2-Gi complex with GSK256073
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8ihb
Q-score: 0.571
Suzuki S, Tanaka K, Nishikawa K, Suzuki H, Oshima A, Fujiyoshi Y
Nat Commun (2023) 14 pp. 5899-5899 [ DOI: doi:10.1038/s41467-023-41650-7 Pubmed: 37736747 ]
- Soluble cytochrome b562,hydroxycarboxylic acid receptor 2 (74 kDa, Protein from Homo sapiens)
- 8-chloranyl-3-pentyl-7h-purine-2,6-dione (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Mus musculus)
- Multiprotein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Mus musculus)
- Scfv16 (26 kDa, Protein from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of HCA2-Gi complex with MK6892
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8ihf
Q-score: 0.537
Suzuki S, Tanaka K, Nishikawa K, Suzuki H, Oshima A, Fujiyoshi Y
Nat Commun (2023) 14 pp. 5899-5899 [ DOI: doi:10.1038/s41467-023-41650-7 Pubmed: 37736747 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Mus musculus)
- Soluble cytochrome b562,hydroxycarboxylic acid receptor 2 (74 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Mus musculus)
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Multiprotein complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of HCA2-Gi complex with LUF6283
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8ihh
Q-score: 0.521
Suzuki S, Tanaka K, Nishikawa K, Suzuki H, Oshima A, Fujiyoshi Y
Nat Commun (2023) 14 pp. 5899-5899 [ DOI: doi:10.1038/s41467-023-41650-7 Pubmed: 37736747 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Mus musculus)
- Soluble cytochrome b562,hydroxycarboxylic acid receptor 2 (74 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Mus musculus)
- Multiprotein complex (Complex from Homo sapiens)
- 5-butyl-1~{h}-pyrazole-3-carboxylic acid (168 Da, Ligand)
- Scfv16 (26 kDa, Protein from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of HCA2-Gi complex with acifran
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 8ihi
Q-score: 0.523
Suzuki S, Tanaka K, Nishikawa K, Suzuki H, Oshima A, Fujiyoshi Y
Nat Commun (2023) 14 pp. 5899-5899 [ DOI: doi:10.1038/s41467-023-41650-7 Pubmed: 37736747 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Mus musculus)
- Soluble cytochrome b562,hydroxycarboxylic acid receptor 2 (74 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Mus musculus)
- (5~{s})-5-methyl-4-oxidanylidene-5-phenyl-furan-2-carboxylic acid (218 Da, Ligand)
- Multiprotein complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of the J-K-St region of EMCV IRES in complex with eIF4G-HEAT1 and eIF4A
Resolution: 3.76 Å
EM Method: Single-particle
Fitted PDBs: 8huj
Q-score: 0.406
Imai S, Suzuki H, Fujiyoshi Y, Shimada I
Nat Commun (2023) 14 pp. 4977-4977 [ DOI: doi:10.1038/s41467-023-40582-6 Pubmed: 37640715 ]
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Eukaryotic initiation factor 4a-i (48 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 4 gamma 1 (31 kDa, Protein from Homo sapiens)
- Ires rna (j-k-st) (34 kDa, RNA from Encephalomyocarditis virus)
- Ternary complex of the j-k-st region of emcv ires with eif4a and eif4g-heat1 (Complex from Homo sapiens)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8j7r
Q-score: 0.407
Imai S, Suzuki H, Fujiyoshi Y, Shimada I
Nat Commun (2023) 14 pp. 4977-4977 [ DOI: doi:10.1038/s41467-023-40582-6 Pubmed: 37640715 ]
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Eukaryotic translation initiation factor 4 gamma 1 (31 kDa, Protein from Homo sapiens)
- Ires rna (j-k-st) (34 kDa, RNA from Encephalomyocarditis virus)
- Ternary complex of the j-k-st region of emcv ires with eif4a and eif4g-heat1 (Complex from Homo sapiens)
Cryo-EM structure of a human ATP11C-CDC50A flippase in E1-AMPPCP state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7bsp
Q-score: 0.477
Nakanishi H, Nishizawa T, Segawa K, Nureki O, Fujiyoshi Y, Nagata S, Abe K
Cell Rep (2020) 32 pp. 108208-108208 [ DOI: doi:10.1016/j.celrep.2020.108208 Pubmed: 32997992 ]
- Human atp11c-cdc50a flippase (180 kDa, Complex from Homo sapiens)
- Atp11c (124 kDa, Protein from Homo sapiens)
- Cdc50a (40 kDa, Protein from Homo sapiens)
- Phosphomethylphosphonic acid adenylate ester (505 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of a human ATP11C-CDC50A flippase in E1AlF-ADP state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7bsq
Q-score: 0.567
Nakanishi H, Nishizawa T, Segawa K, Nureki O, Fujiyoshi Y, Nagata S, Abe K
Cell Rep (2020) 32 pp. 108208-108208 [ DOI: doi:10.1016/j.celrep.2020.108208 Pubmed: 32997992 ]
- Magnesium ion (24 Da, Ligand)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Human atp11c-cdc50a flippase (180 kDa, Complex from Homo sapiens)
- Atp11c (124 kDa, Protein from Homo sapiens)
- Cdc50a (40 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of a human ATP11C-CDC50A flippase in E1AlF state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7bss
Q-score: 0.539
Nakanishi H, Nishizawa T, Segawa K, Nureki O, Fujiyoshi Y, Nagata S, Abe K
Cell Rep (2020) 32 pp. 108208-108208 [ DOI: doi:10.1016/j.celrep.2020.108208 Pubmed: 32997992 ]
- Magnesium ion (24 Da, Ligand)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Human atp11c-cdc50a flippase (180 kDa, Complex from Homo sapiens)
- Atp11c (124 kDa, Protein from Homo sapiens)
- Cdc50a (40 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of a human ATP11C-CDC50A flippase in PtdSer-bound E2BeF state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7bsu
Q-score: 0.572
Nakanishi H, Nishizawa T, Segawa K, Nureki O, Fujiyoshi Y, Nagata S, Abe K
Cell Rep (2020) 32 pp. 108208-108208 [ DOI: doi:10.1016/j.celrep.2020.108208 Pubmed: 32997992 ]
- Magnesium ion (24 Da, Ligand)
- Cell cycle control protein 50a (40 kDa, Protein from Homo sapiens)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Human atp11c-cdc50a flippase (180 kDa, Complex from Homo sapiens)
- Atp11c (124 kDa, Protein from Homo sapiens)
- 1-deoxy-alpha-d-mannopyranose (164 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)