Cryo-EM structure of the GPR101-Gs complex
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8w8q
Q-score: 0.564
Yang Z, Wang JY, Yang F, Zhu KK, Wang GP, Guan Y, Ning SL, Lu Y, Li Y, Zhang C, Zheng Y, Zhou SH, Wang XW, Wang MW, Xiao P, Yi F, Zhang C, Zhang PJ, Xu F, Liu BH, Zhang H, Yu X, Gao N, Sun JP
Nat Chem Biol (2024) 20 pp. 484-492 [ Pubmed: 37945893 DOI: doi:10.1038/s41589-023-01456-6 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of the gpr101-gs complex (Complex from Homo sapiens)
- Nb35 (13 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,probable g-protein coupled receptor 101 (73 kDa, Protein from Homo sapiens)
Cryo-EM structure of the AA-14-bound GPR101-Gs complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8w8r
Q-score: 0.558
Yang Z, Wang JY, Yang F, Zhu KK, Wang GP, Guan Y, Ning SL, Lu Y, Li Y, Zhang C, Zheng Y, Zhou SH, Wang XW, Wang MW, Xiao P, Yi F, Zhang C, Zhang PJ, Xu F, Liu BH, Zhang H, Yu X, Gao N, Sun JP
Nat Chem Biol (2024) 20 pp. 484-492 [ Pubmed: 37945893 DOI: doi:10.1038/s41589-023-01456-6 ]
- Probable g-protein coupled receptor 101 (56 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit (42 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- Cryo-em structure of the aa14-bound gpr101-gs complex (Complex from Homo sapiens)
- 1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea (311 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the AA14-bound GPR101 complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8w8s
Q-score: 0.471
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state2
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7vdh
Q-score: 0.53
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ DOI: doi:10.1038/s41586-021-04077-y Pubmed: 34789875 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with c48/80, state2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{n}-methyl-ethanamine (519 Da, Ligand)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with circular cortistatin-14
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 7vdl
Q-score: 0.5
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ DOI: doi:10.1038/s41586-021-04077-y Pubmed: 34789875 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- The pseudoallergen receptor mrgprx2 complex with circular cortistatin-14 (Complex from Homo sapiens)
- Circular cortistatin-14 (1 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with substance P
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7vdm
Q-score: 0.531
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ DOI: doi:10.1038/s41586-021-04077-y Pubmed: 34789875 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- The pseudoallergen receptor mrgprx2 complex with substance p (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Peptide from protachykinin-1 (1 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12. state1
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 7vuy
Q-score: 0.509
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ DOI: doi:10.1038/s41586-021-04077-y Pubmed: 34789875 ]
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with pamp-12, state1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, state2
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 7vuz
Q-score: 0.459
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ DOI: doi:10.1038/s41586-021-04077-y Pubmed: 34789875 ]
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with pamp-12, state2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, local
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7vv0
Q-score: 0.469
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ DOI: doi:10.1038/s41586-021-04077-y Pubmed: 34789875 ]
- Cholesterol (386 Da, Ligand)
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with pamp-12, local (Complex from Homo sapiens)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Peptide from pro-adrenomedullin (1 kDa, Protein from Homo sapiens)
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with linear cortistatin-14
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 7vv3
Q-score: 0.531
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP
Nature (2021) 600 pp. 164-169 [ DOI: doi:10.1038/s41586-021-04077-y Pubmed: 34789875 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv (30 kDa, Protein from Homo sapiens)
- Cryo-em structure of pseudoallergen receptor mrgprx2 complex with linear cortistatin-14 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)