Structure of the human endogenous PCNA-FEN1 complex - State A
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 8yjh
Q-score: 0.421
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Upstream dna chain j (4 kDa, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Endogenous state a pcna-dna-fen1 complex (Complex from Homo sapiens)
- Downstream dna chain f (3 kDa, DNA from Homo sapiens)
- 5 prime dna (867 Da, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Parent strand chain e (7 kDa, DNA from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State B
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8yjl
Q-score: 0.448
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Endogenous state b pcna-dna-fen1 complex (Complex from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- 5 prime dna (867 Da, DNA from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Upstream dna (5 kDa, DNA from Homo sapiens)
- Parent strand (8 kDa, DNA from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State C
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8yjq
Q-score: 0.441
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Parent strand (8 kDa, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- 5 prime flap dna (1 kDa, DNA from Homo sapiens)
- Upstream dna (5 kDa, DNA from Homo sapiens)
- Endogenous state c pcna-dna-fen1 complex (Complex from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State D
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8yjr
Q-score: 0.423
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- 5 prime flap dna (867 Da, DNA from Homo sapiens)
- Parent dna (9 kDa, DNA from Homo sapiens)
- Upstream dna (6 kDa, DNA from Homo sapiens)
- Endogenous state d pcna-dna-fen1 complex (Complex from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State E
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 8yjs
Q-score: 0.443
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Upstream dna (5 kDa, DNA from Homo sapiens)
- 5 prime flap dna (867 Da, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Endogenous state e pcna-dna-fen1 complex (Complex from Homo sapiens)
- Parent strand dna (8 kDa, DNA from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State F
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 8yju
Q-score: 0.399
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Endogenous state f pcna-dna-fen1 complex (Complex from Homo sapiens)
- 5 prime flap dna (867 Da, DNA from Homo sapiens)
- Parent strand dna (9 kDa, DNA from Homo sapiens)
- Upstream dna (6 kDa, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State G
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8yjv
Q-score: 0.447
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Downstream dna (3 kDa, DNA from Homo sa)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Endogenous state g pcna-dna-fen1 complex (Complex from Homo sapiens)
- 5 prime flap dna (867 Da, DNA from Homo sapiens)
- Upstream dna (6 kDa, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Parent strand dna (9 kDa, DNA from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State H
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Parent strand dna (9 kDa, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- 5 prime flap dna (867 Da, DNA from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Endogenous state h pcna-dna-fen1 complex (Complex from Homo sapiens)
- Upstream dna (6 kDa, DNA from Homo sapiens)
Structure of the human endogenous PCNA-FEN1-RNase H2 complex - State D
Resolution: 5.15 Å
EM Method: Single-particle
Fitted PDBs: 8yjz
Q-score: 0.302
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Ribonuclease h2 subunit c (17 kDa, Protein from Homo sapiens)
- Parent strand dna (9 kDa, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Ribonuclease h2 subunit a (33 kDa, Protein from Homo sapiens)
- Upstream dna (6 kDa, DNA from Homo sapiens)
- Endogenous state d pcna-dna-fen1-rnase h2 complex (Complex from Homo sapiens)
- Downstream dna (4 kDa, DNA from Homo sapiens)
- Ribonuclease h2 subunit b (35 kDa, Protein from Homo sapiens)
Structure of yeast replisome associated with FACT and histone hexamer, Composite map
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8xgc
Q-score: 0.407
Li N, Gao Y, Zhang Y, Yu D, Lin J, Feng J, Li J, Xu Z, Zhang Y, Dang S, Zhou K, Liu Y, Li XD, Tye BK, Li Q, Gao N, Zhai Y
Nature (2024) 627 pp. 890-897 [ DOI: doi:10.1038/s41586-024-07152-2 Pubmed: 38448592 ]
- Histone h4 (11 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae)
- Histone h2b.2 (14 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae)
- Dna polymerase alpha-binding protein (104 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication complex gins protein sld5 (33 kDa, Protein from Saccharomyces cerevisiae)
- Chromosome segregation in meiosis protein 3 (36 kDa, Protein from Saccharomyces cerevisiae)
- Histone h3 (15 kDa, Protein from Saccharomyces cerevisiae)
- Dna (39-mer) (11 kDa, DNA from Saccharomyces cerevisiae)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Mediator of replication checkpoint protein 1 (124 kDa, Protein from Saccharomyces cerevisiae)
- Endogenous replisomes (Complex from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae)
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae)
- Fact complex subunit pob3 (63 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication complex gins protein psf2 (29 kDa, Protein from Saccharomyces cerevisiae)
- Topoisomerase 1-associated factor 1 (141 kDa, Protein from Saccharomyces cerevisiae)
- Histone h2a.1 (14 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication complex gins protein psf3 (21 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae)
- Dna (51-mer) (15 kDa, DNA from Saccharomyces cerevisiae)
- Dna replication complex gins protein psf1 (24 kDa, Protein from Saccharomyces cerevisiae)
- Zinc ion (65 Da, Ligand)
- Cell division control protein 45 (74 kDa, Protein from Saccharomyces cerevisiae)
- Dna polymerase epsilon catalytic subunit a (255 kDa, Protein from Saccharomyces cerevisiae)
- Fact complex subunit spt16 (118 kDa, Protein from Saccharomyces cerevisiae)
- Dna polymerase epsilon subunit b (78 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae)