Modified BG505 SOSIP-based immunogen RC1 in complex with elicited mAb Ab283MUR Fab and 8ANC195 Fab
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
- 8anc195 fab (Complex from Homo sapiens)
- Rc1 sosip (Complex from Human immunodeficiency virus 1)
- Ab283mur fab (Complex from Mus musculus)
- Elicited ab283mur fab in complex with rc1 sosip and bnab 8anc195 fab (600 kDa, Complex)
Modified BG505 SOSIP-based immunogen RC1 in complex with elicited mAb Ab1170NHP Fab and 8ANC195 Fab
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Ab1245 Fab in complex with BG505 SOSIP.664 and 8ANC195 Fab
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7mxe
Q-score: 0.492
Abernathy ME, Gristick HB, Vielmetter J, Keeffe JR, Gnanapragasam PNP, Lee YE, Escolano A, Gautam R, Seaman MS, Martin MA, Nussenzweig MC, Bjorkman PJ
NPJ Vaccines (2021) 6 pp. 126-126 [ DOI: doi:10.1038/s41541-021-00387-4 Pubmed: 34697307 ]
- Bg505 sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein bg505 sosip.664 gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Ab1245 fab light chain (25 kDa, Protein from Macaca mulatta)
- Complex of nhp-isolated ab1245 fab and bnab 8anc195 g52k5 fab bound to bg505 sosip.664 trimer (500 kDa, Complex)
- 8anc195 g52k5 fab heavy chain (26 kDa, Protein from Homo sapiens)
- 8anc195 g52k5 fab light chain (23 kDa, Protein from Homo sapiens)
- 8anc195 g52k5 fab (Complex from Homo sapiens)
- Ab1245 fab (Complex from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ab1245 fab heavy chain (28 kDa, Protein from Macaca mulatta)
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 7kde
Q-score: 0.514
Wang Z, Barnes CO, Gautam R, Cetrulo Lorenzi JC, Mayer CT, Oliveira TY, Ramos V, Cipolla M, Gordon KM, Gristick HB, West AP, Nishimura Y, Raina H, Seaman MS, Gazumyan A, Martin M, Bjorkman PJ, Nussenzweig MC, Escolano A
eLife (2020) 9 [ Pubmed: 33084569 DOI: doi:10.7554/eLife.61991 ]
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Ab 1485 heavy chain (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ab 1485 light chain (23 kDa, Protein from Homo sapiens)
- Ternary complex of hiv-1 env glycoprotein, bg505. sosip.664, with broadly neutralizing antibodies 1485 and 8anc195 (600 kDa, Complex from Homo sapiens)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- 8anc195 fab light chain (23 kDa, Protein from Homo sapiens)
- 8anc195 fab heavy chain (26 kDa, Protein from Homo sapiens)
Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch bNAb 10-1074
Resolution: 4.05 Å
EM Method: Single-particle
Fitted PDBs: 6orn
Q-score: 0.423
Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West Jr AP, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC
Nature (2019) 570 pp. 468-473 [ DOI: doi:10.1038/s41586-019-1250-z Pubmed: 31142836 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rc1 variant of hiv-1 env glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 10-1074 antibody fab light chain (23 kDa, Protein from Homo sapiens)
- 10-1074 antibody fab heavy chain (25 kDa, Protein from Homo sapiens)
- Rc1 variant of bg505 sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- 10-1074 fab (Complex from Homo sapiens)
- Complex of rc1 variant of bg505 sosip.664 trimer with three 10-1074 fabs and three cd4bs fabs (600 kDa, Complex from Human immunodeficiency virus 1)
- Rc1 variant of hiv-1 env glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)