SARS-CoV-2 Spike in complex with neutralizing Fab SARS2-38 (three down conformation)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7mkl
Q-score: 0.228
VanBlargan LA, Adams LJ, Liu Z, Chen RE, Gilchuk P, Raju S, Smith BK, Zhao H, Case JB, Winkler ES, Whitener BM, Droit L, Aziati ID, Bricker TL, Joshi A, Shi PY, Creanga A, Pegu A, Handley SA, Wang D, Boon ACM, Crowe Jr JE, Whelan SPJ, Fremont DH, Diamond MS
Immunity (2021) 54 pp. 2399-2416.e6 [ DOI: doi:10.1016/j.immuni.2021.08.016 Pubmed: 34481543 ]
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars2-38 fv heavy chain (12 kDa, Protein from Mus musculus)
- Sars2-38 fv light chain (11 kDa, Protein from Mus musculus)
- Sars-cov-2 spike bound by sars2-38 antibody fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 Spike RBD in complex with neutralizing Fab SARS2-38 (local refinement)
Resolution: 3.16 Å
EM Method: Single-particle
Fitted PDBs: 7mkm
Q-score: 0.3
VanBlargan LA, Adams LJ, Liu Z, Chen RE, Gilchuk P, Raju S, Smith BK, Zhao H, Case JB, Winkler ES, Whitener BM, Droit L, Aziati ID, Bricker TL, Joshi A, Shi PY, Creanga A, Pegu A, Handley SA, Wang D, Boon ACM, Crowe Jr JE, Whelan SPJ, Fremont DH, Diamond MS
Immunity (2021) 54 pp. 2399-2416.e6 [ DOI: doi:10.1016/j.immuni.2021.08.016 Pubmed: 34481543 ]
- Sars2-38 fv heavy chain (12 kDa, Protein from Mus musculus)
- Sars2-38 fv light chain (11 kDa, Protein from Mus musculus)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike bound by sars2-38 antibody fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Negative stain EM map of SARS-CoV-2 spike protein (trimer) with Fab COV2-2489 (NTD)
Suryadevara N, Shrihari S, Gilchuk P, VanBlargan LA, Binshtein E, Zost SJ, Nargi RS, Sutton RE, Winkler ES, Chen EC, Fouch ME, Davidson E, Doranz BJ, Carnahan RH, Thackray LB, Diamond MS, Crowe JE
bioRxiv (2021) [ Pubmed: 33501445 DOI: doi:10.1101/2021.01.19.427324 ]
Negative stain EM map of SARS-CoV-2 spike protein (trimer) with Fab COV2-2676 (NTD)
Suryadevara N, Shrihari S, Gilchuk P, VanBlargan LA, Binshtein E, Zost SJ, Nargi RS, Sutton RE, Winkler ES, Chen EC, Fouch ME, Davidson E, Doranz BJ, Carnahan RH, Thackray LB, Diamond MS, Crowe JE
bioRxiv (2021) [ Pubmed: 33501445 DOI: doi:10.1101/2021.01.19.427324 ]
Negative stain EM map of SARS CoV-2 spike protein (trimer)
Zost SJ, Gilchuk P, Case JB, Binshtein E, Chen RE, Nkolola JP, Schafer A, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Martinez DR, Williamson LE, Chen EC, Jones T, Day S, Myers L, Hassan AO, Kafai NM, Winkler ES, Fox JM, Shrihari S, Mueller BK, Meiler J, Chandrashekar A, Mercado NB, Steinhardt JJ, Ren K, Loo YM, Kallewaard NL, McCune BT, Keeler SP, Holtzman MJ, Barouch DH, Gralinski LE, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe Jr JE
Nature (2020) 584 pp. 443-449 [ Pubmed: 32668443 DOI: doi:10.1038/s41586-020-2548-6 ]
Negative stain EM map of SARS-CoV-2 spike protein (trimer) with Fab COV2-2165
Zost SJ, Gilchuk P, Case JB, Binshtein E, Chen RE, Nkolola JP, Schafer A, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Martinez DR, Williamson LE, Chen EC, Jones T, Day S, Myers L, Hassan AO, Kafai NM, Winkler ES, Fox JM, Shrihari S, Mueller BK, Meiler J, Chandrashekar A, Mercado NB, Steinhardt JJ, Ren K, Loo YM, Kallewaard NL, McCune BT, Keeler SP, Holtzman MJ, Barouch DH, Gralinski LE, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe Jr JE
Nature (2020) 584 pp. 443-449 [ Pubmed: 32668443 DOI: doi:10.1038/s41586-020-2548-6 ]
Negative stain EM map of SARS-CoV-2 spike protein (trimer) with Fab COV2-2196
Zost SJ, Gilchuk P, Case JB, Binshtein E, Chen RE, Nkolola JP, Schafer A, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Martinez DR, Williamson LE, Chen EC, Jones T, Day S, Myers L, Hassan AO, Kafai NM, Winkler ES, Fox JM, Shrihari S, Mueller BK, Meiler J, Chandrashekar A, Mercado NB, Steinhardt JJ, Ren K, Loo YM, Kallewaard NL, McCune BT, Keeler SP, Holtzman MJ, Barouch DH, Gralinski LE, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe Jr JE
Nature (2020) 584 pp. 443-449 [ Pubmed: 32668443 DOI: doi:10.1038/s41586-020-2548-6 ]
Negative stain EM map of SARS-CoV-2 spike protein (trimer) with Fab COV2-2130
Zost SJ, Gilchuk P, Case JB, Binshtein E, Chen RE, Nkolola JP, Schafer A, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Martinez DR, Williamson LE, Chen EC, Jones T, Day S, Myers L, Hassan AO, Kafai NM, Winkler ES, Fox JM, Shrihari S, Mueller BK, Meiler J, Chandrashekar A, Mercado NB, Steinhardt JJ, Ren K, Loo YM, Kallewaard NL, McCune BT, Keeler SP, Holtzman MJ, Barouch DH, Gralinski LE, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe Jr JE
Nature (2020) 584 pp. 443-449 [ Pubmed: 32668443 DOI: doi:10.1038/s41586-020-2548-6 ]
Negative stain EM map of SARS-CoV-2 spike protein (trimer) with Fab COV2-2130 and Fab COV2-2196
Zost SJ, Gilchuk P, Case JB, Binshtein E, Chen RE, Nkolola JP, Schafer A, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Martinez DR, Williamson LE, Chen EC, Jones T, Day S, Myers L, Hassan AO, Kafai NM, Winkler ES, Fox JM, Shrihari S, Mueller BK, Meiler J, Chandrashekar A, Mercado NB, Steinhardt JJ, Ren K, Loo YM, Kallewaard NL, McCune BT, Keeler SP, Holtzman MJ, Barouch DH, Gralinski LE, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe Jr JE
Nature (2020) 584 pp. 443-449 [ Pubmed: 32668443 DOI: doi:10.1038/s41586-020-2548-6 ]