SARS-CoV-2 Spike NTD in complex with neutralizing Fab SARS2-57 (local refinement)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 7sww
Q-score: 0.328
Adams LJ, VanBlargan LA, Liu Z, Gilchuk P, Zhao H, Chen RE, Raju S, Whitener B, Shrihari S, Jethva PN, Gross ML, Crowe JE, Whelan SPJ, Diamond MS, Fremont DH
To Be Published
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars2-57 fv light chain (12 kDa, Protein from Mus musculus)
- Spike protein s1 (33 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars2-57 fv heavy chain (12 kDa, Protein from Mus musculus)
- Sars-cov-2 spike bound by sars2-57 fab (Complex)
SARS-CoV-2 Spike in complex with neutralizing Fab SARS2-57 (three down conformation)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 7swx
Q-score: 0.446
Adams LJ, VanBlargan LA, Liu Z, Gilchuk P, Zhao H, Chen RE, Raju S, Whitener B, Shrihari S, Jethva PN, Gross ML, Crowe JE, Whelan SPJ, Diamond MS, Fremont DH
To Be Published
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars2-57 fv light chain (12 kDa, Protein from Mus musculus)
- Sars2-57 fv heavy chain (12 kDa, Protein from Mus musculus)
- Sars-cov-2 spike bound by sars2-57 fab (Complex)
- Spike glycoprotein (125 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
EBOV GP bound to rEBOV-442 and rEBOV-515 Fabs
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7m8l
Q-score: 0.433
Gilchuk P, Murin CD, Cross RW, Ilinykh PA, Huang K, Kuzmina N, Borisevich V, Agans KN, Geisbert JB, Zost SJ, Nargi RS, Sutton RE, Suryadevara N, Bombardi RG, Carnahan RH, Bukreyev A, Geisbert TW, Ward AB, Crowe Jr JE
Cell (2021) 184 pp. 5593-5607.e18 [ Pubmed: 34715022 DOI: doi:10.1016/j.cell.2021.09.035 ]
- Rebov-442 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Rebov-442 fab light chain (23 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein 2 (22 kDa, Protein from Ebola virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Virion spike glycoprotein 1 (34 kDa, Protein from Ebola virus)
- Rebov-515 fab light chain (23 kDa, Protein from Homo sapiens)
- Complex of mucin deleted ebola virus gp (makona variant) bound to rebov-442 and rebov-515 fabs (Complex from Ebola virus)
- Rebov-515 fab heavy chain (24 kDa, Protein from Homo sapiens)
BDBV-289 bound to EBOV GPdMuc Makona
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7kej
Q-score: 0.451
Murin CD, Gilchuk P, Ilinykh PA, Huang K, Kuzmina N, Shen X, Bruhn JF, Bryan AL, Davidson E, Doranz BJ, Williamson LE, Copps J, Alkutkar T, Flyak AI, Bukreyev A, Crowe Jr JE, Ward AB
Cell Rep (2021) 35 pp. 108984-108984 [ Pubmed: 33852862 DOI: doi:10.1016/j.celrep.2021.108984 ]
- Antibody fab heavy chain (hc) bdbv-289 (26 kDa, Protein from Homo sapiens)
- Antibody fab light chain (lc) bdbv-289 (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Virion spike glycoprotein (22 kDa, Protein from Zaire ebolavirus)
- Virion spike glycoprotein (34 kDa, Protein from Ebola virus)
- Complex of ebola virus gp (mucin-deleted makona strain) bound to bdbv-289 fab (Complex from Homo sapiens)
SARS-CoV-2 Spike in complex with neutralizing Fab SARS2-38 (three down conformation)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7mkl
Q-score: 0.228
VanBlargan LA, Adams LJ, Liu Z, Chen RE, Gilchuk P, Raju S, Smith BK, Zhao H, Case JB, Winkler ES, Whitener BM, Droit L, Aziati ID, Bricker TL, Joshi A, Shi PY, Creanga A, Pegu A, Handley SA, Wang D, Boon ACM, Crowe Jr JE, Whelan SPJ, Fremont DH, Diamond MS
Immunity (2021) 54 pp. 2399-2416.e6 [ Pubmed: 34481543 DOI: doi:10.1016/j.immuni.2021.08.016 ]
- Sars2-38 fv heavy chain (12 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars2-38 fv light chain (11 kDa, Protein from Mus musculus)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike bound by sars2-38 antibody fab (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Spike RBD in complex with neutralizing Fab SARS2-38 (local refinement)
Resolution: 3.16 Å
EM Method: Single-particle
Fitted PDBs: 7mkm
Q-score: 0.3
VanBlargan LA, Adams LJ, Liu Z, Chen RE, Gilchuk P, Raju S, Smith BK, Zhao H, Case JB, Winkler ES, Whitener BM, Droit L, Aziati ID, Bricker TL, Joshi A, Shi PY, Creanga A, Pegu A, Handley SA, Wang D, Boon ACM, Crowe Jr JE, Whelan SPJ, Fremont DH, Diamond MS
Immunity (2021) 54 pp. 2399-2416.e6 [ Pubmed: 34481543 DOI: doi:10.1016/j.immuni.2021.08.016 ]
- Sars2-38 fv heavy chain (12 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars2-38 fv light chain (11 kDa, Protein from Mus musculus)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike bound by sars2-38 antibody fab (Complex from Severe acute respiratory syndrome coronavirus 2)
Bundibugyo virus GP (mucin deleted) bound to antibody Fab BDBV-43 and ADI-15878
Resolution: 4.16 Å
EM Method: Single-particle
Fitted PDBs: 7kew
Q-score: 0.268
Murin CD, Gilchuk P, Ilinykh PA, Huang K, Kuzmina N, Shen X, Bruhn JF, Bryan AL, Davidson E, Doranz BJ, Williamson LE, Copps J, Alkutkar T, Flyak AI, Bukreyev A, Crowe Jr JE, Ward AB
Cell Rep (2021) 35 pp. 108984-108984 [ Pubmed: 33852862 DOI: doi:10.1016/j.celrep.2021.108984 ]
- Bdbv-43 fab light chain (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein 1 (38 kDa, Protein from Bundibugyo ebolavirus)
- Envelope glycoprotein 2 (19 kDa, Protein from Bundibugyo ebolavirus)
- Bdbv-43 fab heavy chain (26 kDa, Protein from Homo sapiens)
- Bdbv-43 fab (Complex from Homo sapiens)
- Complex of bundibugyo virus gp (mucin deleted) bound to the antibody fab bdbv-43 and adi-15878 (Complex from Bundibugyo ebolavirus)
- Bundibugyo virus gp (mucin deleted) (Complex from Bundibugyo ebolavirus)
Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-442 and EBOV-515
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7kfb
Q-score: 0.409
Murin CD, Gilchuk P, Ilinykh PA, Huang K, Kuzmina N, Shen X, Bruhn JF, Bryan AL, Davidson E, Doranz BJ, Williamson LE, Copps J, Alkutkar T, Flyak AI, Bukreyev A, Crowe Jr JE, Ward AB
Cell Rep (2021) 35 pp. 108984-108984 [ Pubmed: 33852862 DOI: doi:10.1016/j.celrep.2021.108984 ]
- Antibody fab ebov-442 heavy chain (25 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein 2 (22 kDa, Protein from Ebola virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ebola virus gp (mucin deleted, makona strain) (Complex from Ebola virus)
- Virion spike glycoprotein 1 (34 kDa, Protein from Ebola virus)
- Ebola virus gp (mucin deleted, makona strain) bound to antibody fab ebov-442 and ebov-515 (Complex from Ebola virus)
- Antibody fab ebov-442 (Complex from Homo sapiens)
- Antibody fab ebov-442 light chain (23 kDa, Protein from Homo sapiens)
Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-437 and EBOV-515
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7kfh
Q-score: 0.413
Murin CD, Gilchuk P, Ilinykh PA, Huang K, Kuzmina N, Shen X, Bruhn JF, Bryan AL, Davidson E, Doranz BJ, Williamson LE, Copps J, Alkutkar T, Flyak AI, Bukreyev A, Crowe Jr JE, Ward AB
Cell Rep (2021) 35 pp. 108984-108984 [ Pubmed: 33852862 DOI: doi:10.1016/j.celrep.2021.108984 ]
- Antibody fab ebov-437 light chain (23 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein 2 (22 kDa, Protein from Ebola virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Antibody fab ebov-437 heavy chain (25 kDa, Protein from Homo sapiens)
- Ebola virus gp (mucin deleted, makona strain) bound to antibody fab ebov-437 and ebov-515 (Complex from Homo sapiens)
- Virion spike glycoprotein 1 (34 kDa, Protein from Ebola virus)
EBOV GPdMuc (Makona) in complex with rEBOV-520 and rEBOV-548 Fabs
Resolution: 4.12 Å
EM Method: Single-particle
Fitted PDBs: 6pci
Q-score: 0.38
Gilchuk P, Murin CD, Milligan JC, Cross RW, Mire CE, Ilinykh PA, Huang K, Kuzmina N, Altman PX, Hui S, Gunn BM, Bryan AL, Davidson E, Doranz BJ, Turner HL, Alkutkar T, Flinko R, Orlandi C, Carnahan R, Nargi R, Bombardi RG, Vodzak ME, Li S, Okoli A, Ibeawuchi M, Ohiaeri B, Lewis GK, Alter G, Bukreyev A, Saphire EO, Geisbert TW, Ward AB, Crowe Jr JE
Immunity (2020) 52 pp. 388-403.e12 [ DOI: doi:10.1016/j.immuni.2020.01.001 Pubmed: 32023489 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ebola virus (makona) gp (Complex)
- Rebov-520 fab (Complex)
- Rebov-520 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein,virion spike glycoprotein,ebola virus (makona) gp2 (22 kDa, Protein from Ebola virus)
- Rebov-548 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein (31 kDa, Protein from Ebola virus)
- Rebov-520 fab light chain (23 kDa, Protein from Homo sapiens)
- Rebov-548 fab light chain (23 kDa, Protein from Homo sapiens)
- Ebov gpdmuc (makona) in complex with rebov-520 and rebov-548 fabs (450 kDa, Complex from Homo sapiens)
- Rebov-548 fab (Complex)