SARS-CoV-2 Spike NTD in complex with neutralizing Fab SARS2-57 (local refinement)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 7sww
Q-score: 0.328
Adams LJ, VanBlargan LA, Liu Z, Gilchuk P, Zhao H, Chen RE, Raju S, Whitener B, Shrihari S, Jethva PN, Gross ML, Crowe JE, Whelan SPJ, Diamond MS, Fremont DH
To Be Published
- Sars2-57 fv heavy chain (12 kDa, Protein from Mus musculus)
- Spike protein s1 (33 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars2-57 fv light chain (12 kDa, Protein from Mus musculus)
- Sars-cov-2 spike bound by sars2-57 fab (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 Spike in complex with neutralizing Fab SARS2-57 (three down conformation)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 7swx
Q-score: 0.446
Adams LJ, VanBlargan LA, Liu Z, Gilchuk P, Zhao H, Chen RE, Raju S, Whitener B, Shrihari S, Jethva PN, Gross ML, Crowe JE, Whelan SPJ, Diamond MS, Fremont DH
To Be Published
- Sars2-57 fv heavy chain (12 kDa, Protein from Mus musculus)
- Spike glycoprotein (125 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars2-57 fv light chain (12 kDa, Protein from Mus musculus)
- Sars-cov-2 spike bound by sars2-57 fab (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
EBOV GP bound to rEBOV-442 and rEBOV-515 Fabs
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7m8l
Q-score: 0.433
Gilchuk P, Murin CD, Cross RW, Ilinykh PA, Huang K, Kuzmina N, Borisevich V, Agans KN, Geisbert JB, Zost SJ, Nargi RS, Sutton RE, Suryadevara N, Bombardi RG, Carnahan RH, Bukreyev A, Geisbert TW, Ward AB, Crowe Jr JE
Cell (2021) 184 pp. 5593-5607.e18 [ Pubmed: 34715022 DOI: doi:10.1016/j.cell.2021.09.035 ]
- Virion spike glycoprotein 2 (22 kDa, Protein from Ebola virus)
- Rebov-442 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Rebov-515 fab light chain (23 kDa, Protein from Homo sapiens)
- Complex of mucin deleted ebola virus gp (makona variant) bound to rebov-442 and rebov-515 fabs (Complex from Ebola virus)
- Rebov-442 fab light chain (23 kDa, Protein from Homo sapiens)
- Rebov-515 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein 1 (34 kDa, Protein from Ebola virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 Spike in complex with neutralizing Fab SARS2-38 (three down conformation)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7mkl
Q-score: 0.228
VanBlargan LA, Adams LJ, Liu Z, Chen RE, Gilchuk P, Raju S, Smith BK, Zhao H, Case JB, Winkler ES, Whitener BM, Droit L, Aziati ID, Bricker TL, Joshi A, Shi PY, Creanga A, Pegu A, Handley SA, Wang D, Boon ACM, Crowe Jr JE, Whelan SPJ, Fremont DH, Diamond MS
Immunity (2021) 54 pp. 2399-2416.e6 [ DOI: doi:10.1016/j.immuni.2021.08.016 Pubmed: 34481543 ]
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars2-38 fv heavy chain (12 kDa, Protein from Mus musculus)
- Sars2-38 fv light chain (11 kDa, Protein from Mus musculus)
- Sars-cov-2 spike bound by sars2-38 antibody fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 Spike RBD in complex with neutralizing Fab SARS2-38 (local refinement)
Resolution: 3.16 Å
EM Method: Single-particle
Fitted PDBs: 7mkm
Q-score: 0.3
VanBlargan LA, Adams LJ, Liu Z, Chen RE, Gilchuk P, Raju S, Smith BK, Zhao H, Case JB, Winkler ES, Whitener BM, Droit L, Aziati ID, Bricker TL, Joshi A, Shi PY, Creanga A, Pegu A, Handley SA, Wang D, Boon ACM, Crowe Jr JE, Whelan SPJ, Fremont DH, Diamond MS
Immunity (2021) 54 pp. 2399-2416.e6 [ DOI: doi:10.1016/j.immuni.2021.08.016 Pubmed: 34481543 ]
- Sars2-38 fv heavy chain (12 kDa, Protein from Mus musculus)
- Sars2-38 fv light chain (11 kDa, Protein from Mus musculus)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike bound by sars2-38 antibody fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)