Cryo-EM structure of histamine H3 receptor in complex with immethridine and miniGo
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8yn7
Q-score: 0.548
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- 4-(1h-imidazol-4-ylmethyl)pyridine (159 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Engineered guanine nucleotide-binding protein g(o) subunit alpha,guanine nucleotide-binding protein g(o) subunit alpha (25 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (72 kDa, Protein from Homo sapiens)
- Immethridine-h3r-minigo-scfv16 complex (Complex from Homo sapiens)
Cryo-EM structure of histamine H3 receptor in complex with proxyfan and miniGo
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8yn8
Q-score: 0.544
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Engineered guanine nucleotide-binding protein g(o) subunit alpha,guanine nucleotide-binding protein g(o) subunit alpha (25 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Proxyfan-h3r-minigo-scfv16 complex (Complex from Homo sapiens)
- 5-(3-phenylmethoxypropyl)-1h-imidazole (216 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (72 kDa, Protein from Homo sapiens)
Cryo-EM structure of histamine H1 receptor in complex with histamine and miniGq
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8yn2
Q-score: 0.578
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Histamine h1 receptor (80 kDa, Protein from Homo sapiens)
- Histamine-h1r-minigq-scfv16 complex (Complex from Homo sapiens)
- Histamine (111 Da, Ligand)
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (28 kDa, Protein from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGs
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8yn3
Q-score: 0.623
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody nb35 (15 kDa, Protein from synthetic construct)
- Histamine-h2r-minigs-nb35 complex (Complex from Homo sapiens)
- Histamine h2 receptor (62 kDa, Protein from Homo sapiens)
- Histamine (111 Da, Ligand)
- Engineered guanine nucleotide,binding protein g(s) subunit alpha (29 kDa, Protein from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGq
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8yn4
Q-score: 0.515
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Histamine-h2r-minigq-scfv16 complex (Complex from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Histamine h2 receptor (62 kDa, Protein from Homo sapiens)
- Histamine (111 Da, Ligand)
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (28 kDa, Protein from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of histamine H3 receptor in complex with histamine and Gi
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8yn5
Q-score: 0.589
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Histamine-h3r-gi-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Histamine (111 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (72 kDa, Protein from Homo sapiens)
Cryo-EM structure of histamine H3 receptor in complex with imetit and Gi
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8yn6
Q-score: 0.546
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Histamine h3 receptor (72 kDa, Protein from Homo sapiens)
- Imetit-h3r-gi-scfv16 complex (Complex from Homo sapiens)
- 2-(1~{h}-imidazol-5-yl)ethyl carbamimidothioate (170 Da, Ligand)
Cryo-EM structure of histamine H4 receptor in complex with histamine and Gi
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 8yn9
Q-score: 0.628
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Water (18 Da, Ligand)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Histamine h4 receptor (71 kDa, Protein from Homo sapiens)
- Histamine (111 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Histamine-h4r-gi-scfv16 complex (Complex from Homo sapiens)
Cryo-EM structure of histamine H4 receptor in complex with immepip and Gi
Resolution: 2.63 Å
EM Method: Single-particle
Fitted PDBs: 8yna
Q-score: 0.586
Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W
Nat Commun (2024) 15 pp. 8296-8296 [ Pubmed: 39333117 DOI: doi:10.1038/s41467-024-52585-y ]
- Immepip-h4r-gi-scfv16 complex (Complex from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- 4-(1h-imidazol-5-ylmethyl)piperidine (165 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Histamine h4 receptor (71 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Fe-O nanocluster of form-IX in the 4-fold channel of Ureaplasma diversum ferritin
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8wqu
Q-score: 0.613
Wang W, Xi H, Fu D, Ma D, Gong W, Zhao Y, Li X, Wu L, Guo Y, Zhao G, Wang H
J Am Chem Soc (2024) 146 pp. 11657-11668 [ Pubmed: 38641862 DOI: doi:10.1021/jacs.3c13830 ]
- Ferritin (Complex from Ureaplasma diversum)
- Fe (iii) ion (55 Da, Ligand)
- Ferritin (21 kDa, Protein from Ureaplasma diversum)