Cryo-EM structure of human apo GPR156
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8yjp
Q-score: 0.396
Ma X, Chen LN, Liao M, Zhang L, Xi K, Guo J, Shen C, Shen DD, Cai P, Shen Q, Qi J, Zhang H, Zang SK, Dong YJ, Miao L, Qin J, Ji SY, Li Y, Liu J, Mao C, Zhang Y, Chai R
Nat Commun (2024) 15 pp. 10601-10601 [ Pubmed: 39638804 DOI: doi:10.1038/s41467-024-54681-5 ]
- Probable g-protein coupled receptor 156 (38 kDa, Protein from Homo sapiens)
- (21r,24r,27s)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9z)-octadec-9-enoate (777 Da, Ligand)
- Gpr156 (Cellular component from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of human GPR156-Gi3 complex
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8yk0
Q-score: 0.501
Ma X, Chen LN, Liao M, Zhang L, Xi K, Guo J, Shen C, Shen DD, Cai P, Shen Q, Qi J, Zhang H, Zang SK, Dong YJ, Miao L, Qin J, Ji SY, Li Y, Liu J, Mao C, Zhang Y, Chai R
Nat Commun (2024) 15 pp. 10601-10601 [ Pubmed: 39638804 DOI: doi:10.1038/s41467-024-54681-5 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Bos taurus)
- Probable g-protein coupled receptor 156 (32 kDa, Protein from Homo sapiens)
- (21r,24r,27s)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9z)-octadec-9-enoate (777 Da, Ligand)
- Gpr156-gi3 complex (Cellular component from Homo sapiens)
- Probable g-protein coupled receptor 156 (35 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
ASFV RNAP M1249L C-tail occupied complex4 (MCOC4)
Zhu G, Xi F, Zeng W, Zhao Y, Cao W, Liu C, Yang F, Ru Y, Xiao S, Zhang S, Liu H, Tian H, Yang F, Lu B, Sun S, Song H, Sun B, Zhao X, Tang L, Li K, He J, Guo J, Zhu Y, Zhu Z, Sun F, Zheng H
Nat Commun (2025) 16 pp. 501-501 [ Pubmed: 39779680 DOI: doi:10.1038/s41467-024-55683-z ]
- Dna-directed rna polymerase subunit (163 kDa, Protein from African swine fever virus)
- Zinc ion (65 Da, Ligand)
- D339l (38 kDa, Protein from African swine fever virus)
- Asfv rnap m1249l c-tail occupied complex4 (mcoc4) (Complex from African swine fever virus)
- C147l (16 kDa, Protein from African swine fever virus)
- M1249l (144 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb10 homolog (9 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb5 homolog (23 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb3-11 homolog (41 kDa, Protein from African swine fever virus)
- Magnesium ion (24 Da, Ligand)
- C122r (11 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase subunit beta (140 kDa, Protein from African swine fever virus)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8xx4
Q-score: 0.605
Zhu G, Xi F, Zeng W, Zhao Y, Cao W, Liu C, Yang F, Ru Y, Xiao S, Zhang S, Liu H, Tian H, Yang F, Lu B, Sun S, Song H, Sun B, Zhao X, Tang L, Li K, He J, Guo J, Zhu Y, Zhu Z, Sun F, Zheng H
Nat Commun (2025) 16 pp. 501-501 [ Pubmed: 39779680 DOI: doi:10.1038/s41467-024-55683-z ]
- Zinc ion (65 Da, Ligand)
- Asfv rnap elongation complex (Complex from African swine fever virus)
- Dna (5'-d(p*tp*tp*cp*gp*cp*cp*gp*tp*tp*gp*cp*gp*tp*ap*tp*tp*tp*gp*tp*gp*tp*ap*g)-3') (7 kDa, DNA from African swine fever virus)
- Dna-directed rna polymerase rpb5 homolog (23 kDa, Protein from African swine fever virus)
- D339l (9 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase subunit beta (138 kDa, Protein from African swine fever virus)
- Rna (5'-r(p*cp*up*ap*cp*ap*cp*ap*ap*a)-3') (2 kDa, RNA from African swine fever virus)
- Rna polymerase subunit 6 (12 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb10 homolog (9 kDa, Protein from African swine fever virus)
- Magnesium ion (24 Da, Ligand)
- Dna (5'-d(p*cp*gp*cp*ap*ap*cp*gp*gp*cp*gp*a)-3') (3 kDa, DNA from African swine fever virus)
- Dna-directed rna polymerase subunit (162 kDa, Protein from African swine fever virus)
- C122r (11 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb3-11 homolog (41 kDa, Protein from African swine fever virus)
ASFV RNAP M1249L C-tail occupied complex1 (MCOC1)
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8xx5
Q-score: 0.607
Zhu G, Xi F, Zeng W, Zhao Y, Cao W, Liu C, Yang F, Ru Y, Xiao S, Zhang S, Liu H, Tian H, Yang F, Lu B, Sun S, Song H, Sun B, Zhao X, Tang L, Li K, He J, Guo J, Zhu Y, Zhu Z, Sun F, Zheng H
Nat Commun (2025) 16 pp. 501-501 [ Pubmed: 39779680 DOI: doi:10.1038/s41467-024-55683-z ]
- Zinc ion (65 Da, Ligand)
- Dna-directed rna polymerase subunit (162 kDa, Protein from African swine fever virus)
- D339l (38 kDa, Protein from African swine fever virus)
- M1249l (137 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb10 homolog (9 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb5 homolog (23 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb3-11 homolog (41 kDa, Protein from African swine fever virus)
- Asfv rnap m1249l c-tail occupied complex1 (mcoc1) (Complex from African swine fever virus)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerase subunit beta (139 kDa, Protein from African swine fever virus)
- C122r (11 kDa, Protein from African swine fever virus)
- C147l (15 kDa, Protein from African swine fever virus)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8xxp
Q-score: 0.591
Zhu G, Xi F, Zeng W, Zhao Y, Cao W, Liu C, Yang F, Ru Y, Xiao S, Zhang S, Liu H, Tian H, Yang F, Lu B, Sun S, Song H, Sun B, Zhao X, Tang L, Li K, He J, Guo J, Zhu Y, Zhu Z, Sun F, Zheng H
Nat Commun (2025) 16 pp. 501-501 [ Pubmed: 39779680 DOI: doi:10.1038/s41467-024-55683-z ]
- Zinc ion (65 Da, Ligand)
- D339l (16 kDa, Protein from African swine fever virus)
- C147l (11 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb10 homolog (9 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb5 homolog (23 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase subunit beta (139 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb3-11 homolog (41 kDa, Protein from African swine fever virus)
- Magnesium ion (24 Da, Ligand)
- Asfv rnap core complex (Complex from African swine fever virus)
- Dna-directed rna polymerase subunit (162 kDa, Protein from African swine fever virus)
- C122r (11 kDa, Protein from African swine fever virus)
ASFV RNAP M1249L C-tail occupied complex2 (MCOC2)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8xxt
Q-score: 0.525
Zhu G, Xi F, Zeng W, Zhao Y, Cao W, Liu C, Yang F, Ru Y, Xiao S, Zhang S, Liu H, Tian H, Yang F, Lu B, Sun S, Song H, Sun B, Zhao X, Tang L, Li K, He J, Guo J, Zhu Y, Zhu Z, Sun F, Zheng H
Nat Commun (2025) 16 pp. 501-501 [ Pubmed: 39779680 DOI: doi:10.1038/s41467-024-55683-z ]
- Zinc ion (65 Da, Ligand)
- D339l (38 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb10 homolog (9 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb5 homolog (23 kDa, Protein from African swine fever virus)
- M1249l (135 kDa, Protein from African swine fever virus)
- Magnesium ion (24 Da, Ligand)
- Asfv rnap m1249l c-tail occupied complex2 (mcoc2) (Complex from African swine fever virus)
- Dna-directed rna polymerase subunit beta (139 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase subunit (162 kDa, Protein from African swine fever virus)
- C122r (11 kDa, Protein from African swine fever virus)
- C147l (15 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb3-11 homolog (41 kDa, Protein from African swine fever virus)
ASFV RNAP M1249L C-tail occupied complex3 (MCOC3)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xy6
Q-score: 0.519
Zhu G, Xi F, Zeng W, Zhao Y, Cao W, Liu C, Yang F, Ru Y, Xiao S, Zhang S, Liu H, Tian H, Yang F, Lu B, Sun S, Song H, Sun B, Zhao X, Tang L, Li K, He J, Guo J, Zhu Y, Zhu Z, Sun F, Zheng H
Nat Commun (2025) 16 pp. 501-501 [ Pubmed: 39779680 DOI: doi:10.1038/s41467-024-55683-z ]
- Zinc ion (65 Da, Ligand)
- M1249l (66 kDa, Protein from African swine fever virus)
- D339l (16 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb10 homolog (9 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb5 homolog (23 kDa, Protein from African swine fever virus)
- C147l (14 kDa, Protein from African swine fever virus)
- Asfv rnap m1249l c-tail occupied complex3 (mcoc3) (Complex from African swine fever virus)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerase subunit beta (139 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase subunit (162 kDa, Protein from African swine fever virus)
- C122r (11 kDa, Protein from African swine fever virus)
- Dna-directed rna polymerase rpb3-11 homolog (41 kDa, Protein from African swine fever virus)
Cryo-EM of helical fibers formed by two peptides Pyn-K6 and Pyn-(EY)3
Resolution: 3.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 9d70
Q-score: 0.39
Qiao Y, Zia A, Wu G, Liu Z, Guo J, Chu M, He H, Wang F, Xu B
J Am Chem Soc (2025) 147 pp. 2978-2983 [ Pubmed: 39808585 DOI: doi:10.1021/jacs.4c12150 ]
- Pyn-k6 + pyn-ey3 fiber (Complex from synthetic construct)
- Pyr-k6 (1 kDa, Protein from synthetic construct)
- (pyren-1-yl)acetic acid (260 Da, Ligand)
- Pyr-ey3 (1 kDa, Protein from synthetic construct)
Structure of the HER2 (S310F) - pertuzumab (T30S/D31A) complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9l1s
Q-score: 0.459
Bai X, Xu L, Wang Z, Zhuang X, Ning J, Sun Y, Wang H, Guo Y, Xu Y, Guo J, Chen S, Pan L
To Be Published
- Pertuzumab fab heavy chain (24 kDa, Protein from Homo sapiens)
- Her2 (s310f) - pertuzumab (t30s/d31a) complex (Complex from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-2 (70 kDa, Protein from Homo sapiens)
- Pertuzumab fab light chain (23 kDa, Protein from Homo sapiens)