Cryo-EM structure of human apo GPR156
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8yjp
Q-score: 0.396
Ma X, Chen LN, Liao M, Zhang L, Xi K, Guo J, Shen C, Shen DD, Cai P, Shen Q, Qi J, Zhang H, Zang SK, Dong YJ, Miao L, Qin J, Ji SY, Li Y, Liu J, Mao C, Zhang Y, Chai R
Nat Commun (2024) 15 pp. 10601-10601 [ DOI: doi:10.1038/s41467-024-54681-5 Pubmed: 39638804 ]
- Cholesterol (386 Da, Ligand)
- Probable g-protein coupled receptor 156 (38 kDa, Protein from Homo sapiens)
- (21r,24r,27s)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9z)-octadec-9-enoate (777 Da, Ligand)
- Gpr156 (Cellular component from Homo sapiens)
Cryo-EM structure of human GPR156-Gi3 complex
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8yk0
Q-score: 0.501
Ma X, Chen LN, Liao M, Zhang L, Xi K, Guo J, Shen C, Shen DD, Cai P, Shen Q, Qi J, Zhang H, Zang SK, Dong YJ, Miao L, Qin J, Ji SY, Li Y, Liu J, Mao C, Zhang Y, Chai R
Nat Commun (2024) 15 pp. 10601-10601 [ DOI: doi:10.1038/s41467-024-54681-5 Pubmed: 39638804 ]
- Gpr156-gi3 complex (Cellular component from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Probable g-protein coupled receptor 156 (32 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- (21r,24r,27s)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9z)-octadec-9-enoate (777 Da, Ligand)
- Probable g-protein coupled receptor 156 (35 kDa, Protein from Homo sapiens)
Cryo-EM structure of CB1-beta-arrestin1 complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8wu1
Q-score: 0.473
Liao YY, Zhang H, Shen Q, Cai C, Ding Y, Shen DD, Guo J, Qin J, Dong Y, Zhang Y, Li XM
Cell (2023) 186 pp. 5784-5797.e17 [ DOI: doi:10.1016/j.cell.2023.11.017 Pubmed: 38101408 ]
- Fab30 light chain (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of human cannabinoid receptor 1 with effector protein (Complex from Bos taurus)
- Fab30 heavy chain (25 kDa, Protein from Homo sapiens)
- Beta-arrestin-1 (44 kDa, Protein from Bos taurus)
- Cannabinoid receptor 1,vasopressin v2 receptor (50 kDa, Protein from Homo sapiens)
- Methyl n-{1-[(4-fluorophenyl)methyl]-1h-indazole-3-carbonyl}-3-methyl-l-valinate (397 Da, Ligand)
Cryo-EM structure of the inactive CD97
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ikj
Q-score: 0.301
Cryo-EM structure of the CD97-G13 complex
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 8ikl
Q-score: 0.59
Mao C, Zhao RJ, Dong YJ, Gao M, Chen LN, Zhang C, Xiao P, Guo J, Qin J, Shen DD, Ji SY, Zang SK, Zhang H, Wang WW, Shen Q, Sun JP, Zhang Y
Mol Cell (2024) 84 pp. 570-583.e7 [ Pubmed: 38215752 DOI: doi:10.1016/j.molcel.2023.12.020 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(13) subunit alpha isoforms short (26 kDa, Protein from Homo sapiens)
- Adhesion g protein-coupled receptor e5 (Cellular component from Homo sapiens)
- Adhesion g protein-coupled receptor e5 (31 kDa, Protein from Homo sapiens)
Cryo-EM structure of the TRH-bound human TRHR-Gq complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7xw9
Q-score: 0.543
Ji SY, Dong YJ, Chen LN, Zang SK, Wang J, Shen DD, Guo J, Qin J, Zhang H, Wang WW, Shen Q, Zhang Y, Song Z, Mao C
Cell Discov (2022) 8 pp. 116-116 [ Pubmed: 36280665 DOI: doi:10.1038/s41421-022-00477-0 ]
- Thyrotropin-releasing hormone receptor (45 kDa, Protein from Homo sapiens)
- Trh peptide (362 Da, Protein from synthetic construct)
- Cryo-em structure of the trh-bound trhr-gq complex (180 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- G protein (Complex from Homo sapiens)
- Trh peptide (Complex)
- Thyrotropin-releasing hormone receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (46 kDa, Protein from Homo sapiens)
- Antibody (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Single fab chain (svfv16) (28 kDa, Protein from synthetic construct)
Cryo-EM structure of the SS-14-bound human SSTR2-Gi1 complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7wic
Q-score: 0.509
Chen LN, Wang WW, Dong YJ, Shen DD, Guo J, Yu X, Qin J, Ji SY, Zhang H, Shen Q, He Q, Yang B, Zhang Y, Li Q, Mao C
Cell Res (2022) 32 pp. 785-788 [ DOI: doi:10.1038/s41422-022-00669-z Pubmed: 35578016 ]
- Cryo-em structure of the ss-14-bound sstr2-gi1 complex (180 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- G protein (Complex from Homo sapiens)
- Somatostatin receptor type 2 (41 kDa, Protein from Homo sapiens)
- Somatostatin-14 (1 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 2 (Complex from Homo sapiens)
- Antibody (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Single fab chain (svfv16) (28 kDa, Protein from synthetic construct)