Cryo-EM structure of human apo GPR156
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8yjp
Q-score: 0.396
Ma X, Chen LN, Liao M, Zhang L, Xi K, Guo J, Shen C, Shen DD, Cai P, Shen Q, Qi J, Zhang H, Zang SK, Dong YJ, Miao L, Qin J, Ji SY, Li Y, Liu J, Mao C, Zhang Y, Chai R
Nat Commun (2024) 15 pp. 10601-10601 [ DOI: doi:10.1038/s41467-024-54681-5 Pubmed: 39638804 ]
- Cholesterol (386 Da, Ligand)
- Probable g-protein coupled receptor 156 (38 kDa, Protein from Homo sapiens)
- (21r,24r,27s)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9z)-octadec-9-enoate (777 Da, Ligand)
- Gpr156 (Cellular component from Homo sapiens)
Cryo-EM structure of mGlu2-mGlu4 bound mGlu2 agonist LY379268
mGlu2-4 heterodimer bound with Gi
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8wgb
Q-score: 0.331
Huang W, Jin N, Guo J, Shen C, Xu C, Xi K, Bonhomme L, Quast RB, Shen DD, Qin J, Liu YR, Song Y, Gao Y, Margeat E, Rondard P, Pin JP, Zhang Y, Liu J
Nat Commun (2024) 15 pp. 10345-10345 [ DOI: doi:10.1038/s41467-024-54744-7 Pubmed: 39609406 ]
- Mglu2-mglu4 heterodimer bound gi (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 4 (98 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
- Metabotropic glutamate receptor 2 (93 kDa, Protein from Homo sapiens)
- (1r,2s)-2-[[3,5-bis(chloranyl)phenyl]carbamoyl]cyclohexane-1-carboxylic acid (316 Da, Ligand)
Cryo-EM focused refined map of mGlu2-mGlu4 heterodimer bound with Gi
Cryo-EM focused refined map of mGlu2-mGlu4 heterodimer bound with Gi
Cryo-EM structure of the [Pyr1]-apelin-13-bound human APLNR-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xzg
Q-score: 0.495
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Apelin-13 (1 kDa, Protein from Homo sapiens)
- Cryo-em structure of the [pyr1]-apelin-13-bound human aplnr-gi complex (Complex from Homo sapiens)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of CB1-beta-arrestin1 complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8wu1
Q-score: 0.473
Liao YY, Zhang H, Shen Q, Cai C, Ding Y, Shen DD, Guo J, Qin J, Dong Y, Zhang Y, Li XM
Cell (2023) 186 pp. 5784-5797.e17 [ DOI: doi:10.1016/j.cell.2023.11.017 Pubmed: 38101408 ]
- Fab30 light chain (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of human cannabinoid receptor 1 with effector protein (Complex from Bos taurus)
- Fab30 heavy chain (25 kDa, Protein from Homo sapiens)
- Beta-arrestin-1 (44 kDa, Protein from Bos taurus)
- Cannabinoid receptor 1,vasopressin v2 receptor (50 kDa, Protein from Homo sapiens)
- Methyl n-{1-[(4-fluorophenyl)methyl]-1h-indazole-3-carbonyl}-3-methyl-l-valinate (397 Da, Ligand)
Cryo-EM structure of the WN561-bound human APLNR-Gi complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xzf
Q-score: 0.578
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Wn561 (1 kDa, Protein from synthetic construct)
- Cryo-em structure of the wn561-bound human aplnr-gi complex (Complex from Homo sapiens)
- Apelin receptor (42 kDa, Protein from Homo sapiens)