Cryo-EM structure of human TPC2 channel in the ligand-bound open state
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6nq0
Q-score: 0.455
Cryo-EM structure of human TPC2 channel in the apo state
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6nq1
Q-score: 0.441
She J, Zeng W, Guo J, Chen Q, Bai X, Jiang Y
eLife (2019) 8 [ DOI: doi:10.7554/eLife.45222 Pubmed: 30860481 ]
- Two pore calcium channel protein 2 (85 kDa, Protein from Homo sapiens)
- Two-pore channel 2 (Complex from Homo sapiens)
Cryo-EM structure of human TPC2 channel in the ligand-bound closed state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6nq2
Q-score: 0.491
She J, Zeng W, Guo J, Chen Q, Bai X, Jiang Y
eLife (2019) 8 [ DOI: doi:10.7554/eLife.45222 Pubmed: 30860481 ]
- Two pore calcium channel protein 2 (85 kDa, Protein from Homo sapiens)
- (2r)-3-{[(s)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate (746 Da, Ligand)
- The complex of two-pore channel 2 with pi(3,5)p2 (Complex from Homo sapiens)
Cryo-EM structure of mouse TPC1 channel in the apo state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6c96
Q-score: 0.456
She J, Guo J, Chen Q, Zeng W, Jiang Y, Bai XC
Nature (2018) 556 pp. 130-134 [ Pubmed: 29562233 DOI: doi:10.1038/nature26139 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Apo mouse tpc1 (Cellular component from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Two pore calcium channel protein 1 (95 kDa, Protein from Mus musculus)
Cryo-EM structure of mouse TPC1 channel in the PtdIns(3,5)P2-bound state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6c9a
Q-score: 0.49
She J, Guo J, Chen Q, Zeng W, Jiang Y, Bai XC
Nature (2018) 556 pp. 130-134 [ Pubmed: 29562233 DOI: doi:10.1038/nature26139 ]
- Ptdins(3,5)p2-bound mouse tpc1 (Cellular component from Mus musculus)
- (2r)-3-{[(s)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate (746 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Two pore calcium channel protein 1 (95 kDa, Protein from Mus musculus)
cryo-EM structure of TRPM4 in apo state with short coiled coil at 3.1 angstrom resolution
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 6bcj
Q-score: 0.502
Guo J, She J, Zeng W, Chen Q, Bai XC, Jiang Y
Nature (2017) 552 pp. 205-209 [ DOI: doi:10.1038/nature24997 Pubmed: 29211714 ]
- Sodium ion (22 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 4 (140 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Homotetramer of mouse trpm4 (Complex from Mus musculus)
cryo-EM structure of TRPM4 in apo state with long coiled coil at 3.5 angstrom resolution
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 6bcl
Q-score: 0.43
Guo J, She J, Zeng W, Chen Q, Bai XC, Jiang Y
Nature (2017) 552 pp. 205-209 [ DOI: doi:10.1038/nature24997 Pubmed: 29211714 ]
- Sodium ion (22 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 4 (140 kDa, Protein from Mus musculus)
- Homotetramer of mouse trpm4 (Complex from Mus musculus)
cryo-EM structure of TRPM4 in ATP bound state with short coiled coil at 2.9 angstrom resolution
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 6bco
Q-score: 0.509
Guo J, She J, Zeng W, Chen Q, Bai XC, Jiang Y
Nature (2017) 552 pp. 205-209 [ DOI: doi:10.1038/nature24997 Pubmed: 29211714 ]
- Homotetramer mouse trpm4 (Complex from Mus musculus)
- Transient receptor potential cation channel subfamily m member 4 (140 kDa, Protein from Mus musculus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
cryo-EM structure of TRPM4 in ATP bound state with long coiled coil at 3.3 angstrom resolution
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 6bcq
Q-score: 0.433
Guo J, She J, Zeng W, Chen Q, Bai XC, Jiang Y
Nature (2017) 552 pp. 205-209 [ DOI: doi:10.1038/nature24997 Pubmed: 29211714 ]
- Transient receptor potential cation channel subfamily m member 4 (140 kDa, Protein from Mus musculus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Homotetramer of mouse trpm4 (Complex from Mus musculus)
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 5wpq
Q-score: 0.432
Chen Q, She J, Zeng W, Guo J, Xu H, Bai XC, Jiang Y
Nature (2017) 550 pp. 415-418 [ Pubmed: 29019981 DOI: doi:10.1038/nature24035 ]
- Homotetramer of mouse trpml1 (66 kDa, Cellular component from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Mucolipin-1 (66 kDa, Protein from Mus musculus)