Cryo-EM structure of neutralizing antibody 8G3 in complex with BA.1 RBD
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9js4
Q-score: 0.434
Liao Y, Ma H, Wang Z, Wang S, He Y, Chang Y, Zong H, Tang H, Wang L, Ke Y, Cai H, Li P, Tang J, Chen H, Drelich A, Peng BH, Hsu J, Tat V, Tseng CK, Song J, Yuan Y, Wu M, Liu J, Yue Y, Zhang X, Wang Z, Yang L, Li J, Ni X, Li H, Xiang Y, Bian Y, Zhang B, Yin H, Dimitrov DS, Gilly J, Han L, Jiang H, Xie Y, Zhu J
PNAS (2025) 122 pp. e2406659122-e2406659122 [ Pubmed: 39908098 DOI: doi:10.1073/pnas.2406659122 ]
- Cryo-em structure of neutralizing antibody 8g3 in complex with ba.1 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (137 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Heavy chain of 8g3 (23 kDa, Protein from Homo heidelbergensis)
- Light chain of 8g3 (23 kDa, Protein from Homo sapiens)
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 8sbb
Q-score: 0.46
Guo X, Zhang J, Han L, Lee J, Williams SC, Forsberg A, Xu Y, Austin RN, Feng L
Nat Commun (2023) 14 pp. 2180-2180 [ Pubmed: 37069165 DOI: doi:10.1038/s41467-023-37869-z ]
- Nanobody (14 kDa, Protein from synthetic construct)
- Alkane 1-monooxygenase (45 kDa, Protein from Fontimonas thermophila)
- Ftaklb-nanobody (Complex from Fontimonas thermophila)
- Fe (iii) ion (55 Da, Ligand)
- Dodecane (170 Da, Ligand)
Cytochrome c-type biogenesis protein CcmABCD from E. coli
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7f02
Q-score: 0.491
Li J, Zheng W, Gu M, Han L, Luo Y, Yu K, Sun M, Zong Y, Ma X, Liu B, Lowder EP, Mendez DL, Kranz RG, Zhang K, Zhu J
Nat Commun (2022) 13 pp. 6422-6422 [ DOI: doi:10.1038/s41467-022-34136-5 Pubmed: 36307425 ]
- Phosphate ion (94 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Heme exporter protein b (23 kDa, Protein from Escherichia coli BL21(DE3))
- Heme exporter protein c (27 kDa, Protein from Escherichia coli BL21(DE3))
- Heme exporter protein d (7 kDa, Protein from Escherichia coli BL21(DE3))
- Cytochrome c-type biogenesis protein ccmabcd (130 kDa, Complex from Escherichia coli BL21(DE3))
- Cytochrome c biogenesis atp-binding export protein ccma (23 kDa, Protein from Escherichia coli BL21(DE3))
- Magnesium ion (24 Da, Ligand)
Cytochrome c-type biogenesis protein CcmABCD from E. coli in complex with ANP
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 7f03
Q-score: 0.498
Li J, Zheng W, Gu M, Han L, Luo Y, Yu K, Sun M, Zong Y, Ma X, Liu B, Lowder EP, Mendez DL, Kranz RG, Zhang K, Zhu J
Nat Commun (2022) 13 pp. 6422-6422 [ DOI: doi:10.1038/s41467-022-34136-5 Pubmed: 36307425 ]
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Water (18 Da, Ligand)
- Heme exporter protein b (23 kDa, Protein from Escherichia coli BL21(DE3))
- Heme exporter protein c (27 kDa, Protein from Escherichia coli BL21(DE3))
- Heme exporter protein d (7 kDa, Protein from Escherichia coli BL21(DE3))
- Cytochrome c-type biogenesis protein ccmabcd (130 kDa, Complex from Escherichia coli BL21(DE3))
- Cytochrome c biogenesis atp-binding export protein ccma (23 kDa, Protein from Escherichia coli BL21(DE3))
- Magnesium ion (24 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
Cytochrome c-type biogenesis protein CcmABCD from E. coli in complex with Heme and ATP.
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 7f04
Q-score: 0.561
Li J, Zheng W, Gu M, Han L, Luo Y, Yu K, Sun M, Zong Y, Ma X, Liu B, Lowder EP, Mendez DL, Kranz RG, Zhang K, Zhu J
Nat Commun (2022) 13 pp. 6422-6422 [ DOI: doi:10.1038/s41467-022-34136-5 Pubmed: 36307425 ]
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Heme exporter protein b (23 kDa, Protein from Escherichia coli BL21(DE3))
- Heme exporter protein c (27 kDa, Protein from Escherichia coli BL21(DE3))
- Heme exporter protein d (7 kDa, Protein from Escherichia coli BL21(DE3))
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Cytochrome c-type biogenesis protein ccmabcd (130 kDa, Complex from Escherichia coli BL21(DE3))
- Cytochrome c biogenesis atp-binding export protein ccma (23 kDa, Protein from Escherichia coli BL21(DE3))
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
Cytochrome c-type biogenesis protein CcmABCD
Resolution: 3.98 Å
EM Method: Single-particle
Fitted PDBs: 7vfj
Q-score: 0.323
Li J, Zheng W, Gu M, Han L, Luo Y, Yu K, Sun M, Zong Y, Ma X, Liu B, Lowder EP, Mendez DL, Kranz RG, Zhang K, Zhu J
Nat Commun (2022) 13 pp. 6422-6422 [ DOI: doi:10.1038/s41467-022-34136-5 Pubmed: 36307425 ]
- Heme exporter protein b (23 kDa, Protein from Escherichia coli BL21(DE3))
- Heme exporter protein c (27 kDa, Protein from Escherichia coli BL21(DE3))
- Heme exporter protein d (7 kDa, Protein from Escherichia coli BL21(DE3))
- Cytochrome c biogenesis atp-binding export protein ccma (23 kDa, Protein from Escherichia coli BL21(DE3))
- The cytochrome c maturation complex ccmabcd. (130 kDa, Complex from Escherichia coli BL21(DE3))
Cytochrome c-type biogenesis protein CcmABCD from E. coli in complex with heme and single ATP
Resolution: 4.03 Å
EM Method: Single-particle
Fitted PDBs: 7vfp
Q-score: 0.31
Li J, Zheng W, Gu M, Han L, Luo Y, Yu K, Sun M, Zong Y, Ma X, Liu B, Lowder EP, Mendez DL, Kranz RG, Zhang K, Zhu J
Nat Commun (2022) 13 pp. 6422-6422 [ DOI: doi:10.1038/s41467-022-34136-5 Pubmed: 36307425 ]
- Water (18 Da, Ligand)
- Heme exporter protein b (23 kDa, Protein from Escherichia coli BL21(DE3))
- Heme exporter protein c (27 kDa, Protein from Escherichia coli BL21(DE3))
- Heme exporter protein d (7 kDa, Protein from Escherichia coli BL21(DE3))
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- The cytochrome c maturation complex ccmabcd (130 kDa, Complex from Escherichia coli BL21(DE3))
- Cytochrome c biogenesis atp-binding export protein ccma (22 kDa, Protein from Escherichia coli BL21(DE3))
Omicron spike trimer with 6m6 antibody
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7wjy
Q-score: 0.31
Wang Y, Zhan W, Liu J, Wang Y, Zhang X, Zhang M, Han L, Ma Y, Lu L, Wen Y, Chen Z, Zhao J, Wu F, Sun L, Huang J
Cell Res (2022) 32 pp. 862-865 [ DOI: doi:10.1038/s41422-022-00684-0 Pubmed: 35768499 ]
- 6m6 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 6m6 light chain (22 kDa, Protein from Homo sapiens)
- Omicron spike with 6m6 (Complex)
- 6m6 heavy chain (24 kDa, Protein from Homo sapiens)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
Omicron Spike bitrimer with 6m6 antibody
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 7wjz
Q-score: 0.288
Wang Y, Zhan W, Liu J, Wang Y, Zhang X, Zhang M, Han L, Ma Y, Lu L, Wen Y, Chen Z, Zhao J, Wu F, Sun L, Huang J
Cell Res (2022) 32 pp. 862-865 [ DOI: doi:10.1038/s41422-022-00684-0 Pubmed: 35768499 ]
- 6m6 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 6m6 light chain (22 kDa, Protein from Homo sapiens)
- Omicron spike with 6m6 (Complex)
- 6m6 heavy chain (24 kDa, Protein from Homo sapiens)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
Local refine of Omicron spike bitrimer with 6m6 antibody
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 7wk0
Q-score: 0.431
Wang Y, Zhan W, Liu J, Wang Y, Zhang X, Zhang M, Han L, Ma Y, Lu L, Wen Y, Chen Z, Zhao J, Wu F, Sun L, Huang J
Cell Res (2022) 32 pp. 862-865 [ DOI: doi:10.1038/s41422-022-00684-0 Pubmed: 35768499 ]
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 6m6 light chain (22 kDa, Protein from Homo sapiens)
- Bn03 (Complex from Homo sapiens)
- Omicron spike with bn03 (Complex)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- 6m6 heavy chain (24 kDa, Protein from Homo sapiens)