Resolution: 3.75 Å
EM Method: Single-particle
Fitted PDBs: 8jmm
Q-score: 0.189
Hao A, Mao Q, Chen Z, Huang J, Sun L
To Be Published
- Gw01 fv (26 kDa, Protein from Homo sapiens)
- 7f3 fv (27 kDa, Protein from Homo sapiens)
- Spike glycoprotein (143 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Xbb spike protein (s) in complex with bispecific antibody g7-fc (Complex from Homo sapiens)
XBB spike protein (S) in complex with monoclonal antibody 6I18
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8jio
Q-score: 0.225
To Be Published
- 6i18 light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (143 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 6i18 heavy chain (49 kDa, Protein from Homo sapiens)
- Xbb spike protein (s) in complex with monoclonal antibody 6i18 (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 tetrameric complex
Resolution: 7.86 Å
EM Method: Single-particle
Fitted PDBs: 8h33
Q-score: 0.07
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ DOI: doi:10.1038/s41594-023-01182-6 Pubmed: 38332366 ]
- E3 ubiquitin-protein ligase rbx1 (13 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cullin-3 (90 kDa, Protein from Homo sapiens)
- Kelch repeat and btb domain-containing protein 2 (71 kDa, Protein from Homo sapiens)
- Kbtbd2-cul3-rbx1 tetrameric complex (Complex from Homo sapiens)
Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 hexameric complex
Resolution: 7.99 Å
EM Method: Single-particle
Fitted PDBs: 8h34
Q-score: 0.088
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ DOI: doi:10.1038/s41594-023-01182-6 Pubmed: 38332366 ]
- E3 ubiquitin-protein ligase rbx1 (13 kDa, Protein from Homo sapiens)
- Kbtbd2-cul3-rbx1 hexameric complex (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cullin-3 (89 kDa, Protein from Homo sapiens)
- Kelch repeat and btb domain-containing protein 2 (71 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 octameric complex
Resolution: 7.41 Å
EM Method: Single-particle
Fitted PDBs: 8h35
Q-score: 0.091
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ DOI: doi:10.1038/s41594-023-01182-6 Pubmed: 38332366 ]
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Kbtbd2-cul3-rbx1 octameric complex (Complex from Homo sapiens)
- Cullin-3 (89 kDa, Protein from Homo sapiens)
- Kelch repeat and btb domain-containing protein 2 (71 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a dimeric complex
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 8h36
Q-score: 0.068
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ DOI: doi:10.1038/s41594-023-01182-6 Pubmed: 38332366 ]
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Kelch repeat and btb domain-containing protein 2 (71 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Kbtbd2-cul3-rbx1-p85a dimeric complex (Complex from Homo sapiens)
- Cullin-3 (89 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a tetrameric complex
Resolution: 7.52 Å
EM Method: Single-particle
Fitted PDBs: 8h37
Q-score: 0.057
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ DOI: doi:10.1038/s41594-023-01182-6 Pubmed: 38332366 ]
- Kbtbd2-cul3-rbx1-p85a tetrameric complex (Complex from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Kelch repeat and btb domain-containing protein 2 (71 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cullin-3 (89 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the KBTBD2-CRL3~N8-CSN(mutate) complex
Resolution: 4.25 Å
EM Method: Single-particle
Fitted PDBs: 8h38
Q-score: 0.078
Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L
Nat Struct Mol Biol (2024) 31 pp. 336-350 [ DOI: doi:10.1038/s41594-023-01182-6 Pubmed: 38332366 ]
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Csn subunit1, kbtbd2, cullin-3, rbx1 (Complex)
- Kbtbd2-crl3~n8 dimer assemble with csn(mutate) monomer (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 3 (47 kDa, Protein from Homo sapiens)
- Nedd8 (Complex)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cop9 signalosome complex subunit 6 (36 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (59 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (37 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (29 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Cullin-3 (89 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Kelch repeat and btb domain-containing protein 2 (71 kDa, Protein from Homo sapiens)
- Csn (Complex)
local refinement of CSN1/2/4/5/6-CRL3/CTD-N8: KBTBD2-CRL3-CSN(mutate) complex