Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 8ha0
Q-score: 0.485
Zhao LH, Yuan QN, Dai AT, He XH, Chen CW, Zhang C, Xu YW, Zhou Y, Wang MW, Yang DH, Xu HE
Acta Pharmacol.Sin. (2023) 44 pp. 1227-1237 [ DOI: doi:10.1038/s41401-022-01032-z Pubmed: 36482086 ]
- Nanobody 35 (15 kDa, Protein from synthetic construct)
- Palmitic acid (256 Da, Ligand)
- Pth-pthr g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha (41 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Parathyroid hormone (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8haf
Q-score: 0.43
Zhao LH, Yuan QN, Dai AT, He XH, Chen CW, Zhang C, Xu YW, Zhou Y, Wang MW, Yang DH, Xu HE
Acta Pharmacol.Sin. (2023) 44 pp. 1227-1237 [ DOI: doi:10.1038/s41401-022-01032-z Pubmed: 36482086 ]
- Nanobody 35 (15 kDa, Protein from synthetic construct)
- Palmitic acid (256 Da, Ligand)
- Pthrp[1-36] (4 kDa, Protein from Homo sapiens)
- Pth-pthr g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha-1 (41 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
Human parathyroid hormone receptor-1 dimer
Resolution: 3.76 Å
EM Method: Single-particle
Fitted PDBs: 8hao
Q-score: 0.206
Zhao LH, Yuan QN, Dai AT, He XH, Chen CW, Zhang C, Xu YW, Zhou Y, Wang MW, Yang DH, Xu HE
Acta Pharmacol.Sin. (2023) 44 pp. 1227-1237 [ DOI: doi:10.1038/s41401-022-01032-z Pubmed: 36482086 ]
- Nanobody 35 (15 kDa, Protein from synthetic construct)
- Pth-pthr g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Parathyroid hormone (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha (41 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
Cryo-EM structure of an activated VIP1 receptor-G protein complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6vn7
Q-score: 0.427
Duan J, Shen DD, Zhou XE, Bi P, Liu QF, Tan YX, Zhuang YW, Zhang HB, Xu PY, Huang SJ, Ma SS, He XH, Melcher K, Zhang Y, Xu HE, Jiang Y
Nat Commun (2020) 11 pp. 4121-4121 [ DOI: doi:10.1038/s41467-020-17933-8 Pubmed: 32807782 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Vasoactive intestinal polypeptide receptor 1 (66 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Pituitary adenylate cyclase-activating polypeptide (3 kDa, Protein from Homo sapiens)
- Pacap27-vip1r-gs protein complex stabilized by nanobody 35 and nanobit system (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nanobody 35 (14 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)