LPI-bound GPR55 in complex with G13
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8zx4
Q-score: 0.531
Xia R, Yuan Q, Wang N, Hou L, Abe J, Song J, Ito Y, Xu HE, He Y
Cell Res (2025) 35 pp. 76-79 [ DOI: doi:10.1038/s41422-024-01044-w Pubmed: 39482404 ]
- Engineered minigalpha 13 (26 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- [(2~{r})-2-oxidanyl-3-[oxidanyl-[(2~{s},3~{r},5~{r},6~{r})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propyl] hexadecanoate (572 Da, Ligand)
- G-protein coupled receptor 55 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
AM251-bound GPR55 in complex with G13
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8zx5
Q-score: 0.426
Xia R, Yuan Q, Wang N, Hou L, Abe J, Song J, Ito Y, Xu HE, He Y
Cell Res (2025) 35 pp. 76-79 [ DOI: doi:10.1038/s41422-024-01044-w Pubmed: 39482404 ]
- Engineered minigalpha 13 (26 kDa, Protein from Homo sapiens)
- Gpcr/g-protein complex (Complex from Homo sapiens)
- 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-~{n}-piperidin-1-yl-pyrazole-3-carboxamide (555 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 55 (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of URAT1(R477S)
He J, Liu G, Kong F, Tan Q, Wang Z, Yang M, He Y, Jia X, Yan C, Wang C, Qian H
Cell Rep (2024) 43 pp. 114628-114628 [ DOI: doi:10.1016/j.celrep.2024.114628 Pubmed: 39146184 ]
- Solute carrier family 22 member 12 (58 kDa, Protein from Homo sapiens)
- Cryo-em structure of urat1(r477s) (Cell from Homo sapiens)
He J, Liu G, Kong F, Tan Q, Wang Z, Yang M, He Y, Jia X, Yan C, Wang C, Qian H
Cell Rep (2024) 43 pp. 114628-114628 [ DOI: doi:10.1016/j.celrep.2024.114628 Pubmed: 39146184 ]
- Solute carrier family 22 member 11 (56 kDa, Protein from Homo sapiens)
- Cryo-em structure of oat4 (Cell from Homo sapiens)
- Chloride ion (35 Da, Ligand)
Cryo-EM structure of URAT1(R477S)-Urate complex
He J, Liu G, Kong F, Tan Q, Wang Z, Yang M, He Y, Jia X, Yan C, Wang C, Qian H
Cell Rep (2024) 43 pp. 114628-114628 [ DOI: doi:10.1016/j.celrep.2024.114628 Pubmed: 39146184 ]
- Solute carrier family 22 member 12 (58 kDa, Protein from Homo sapiens)
- Uric acid (168 Da, Ligand)
- Cryo-em structure of urat1(r477s)-urate complex (Complex from Homo sapiens)
LPS-bound P2Y10 in complex with G13
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8kgg
Q-score: 0.518
Yin H, Kamakura N, Qian Y, Tatsumi M, Ikuta T, Liang J, Xu Z, Xia R, Zhang A, Guo C, Inoue A, He Y
Cell Chem Biol (2024) 31 pp. 1899-1908.e5 [ Pubmed: 39265572 DOI: doi:10.1016/j.chembiol.2024.08.005 ]
- Gpcr/g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-2,guanine nucleotide-binding protein subunit alpha-13 (26 kDa, Protein from Homo sapiens)
- (2~{s})-2-$l^{4}-azanyl-3-[[(2~{r})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid (497 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Putative p2y purinoceptor 10 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Structure of HCoV-HKU1A spike in the functionally anchored-3up conformation with 3TMPRSS2
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8y7x
Q-score: 0.331
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ Pubmed: 38964329 DOI: doi:10.1016/j.cell.2024.06.016 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (141 kDa, Protein from Human coronavirus HKU1 (isolate N1))
- Hku1a-tmprss2 complex (Complex from Human coronavirus HKU1)
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
Local structure of HCoV-HKU1A spike in complex with TMPRSS2 and glycan
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8y7y
Q-score: 0.577
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ Pubmed: 38964329 DOI: doi:10.1016/j.cell.2024.06.016 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hku1a-tmprss2 complex (Complex from Human coronavirus HKU1)
- Methyl 9-o-acetyl-5-acetamido-3,5-dideoxy-d-glycero-alpha-d-galacto-non-2-ulopyranosidonic acid (365 Da, Ligand)
- Spike glycoprotein (141 kDa, Protein from Human coronavirus HKU1 (isolate N1))
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
Structure of HCoV-HKU1C spike in the functionally anchored-1up conformation with 1TMPRSS2
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8y87
Q-score: 0.355
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ Pubmed: 38964329 DOI: doi:10.1016/j.cell.2024.06.016 ]
- Spike glycoprotein (140 kDa, Protein from Human coronavirus HKU1 (isolate N5))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hku1b-tmprss2 complex (Complex from Human coronavirus HKU1)
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
Structure of HCoV-HKU1C spike in the functionally anchored-2up conformation with 2TMPRSS2
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8y88
Q-score: 0.37
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ Pubmed: 38964329 DOI: doi:10.1016/j.cell.2024.06.016 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (140 kDa, Protein from Human coronavirus HKU1)
- Hku1a-tmprss2 complex (Complex from Human coronavirus HKU1)
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)