Cryo-EM structure of an Escherichia coli TnaC-ribosome complex stalled in response to L-tryptophan
van der Stel AX, Gordon ER, Sengupta A, Martínez AK, Klepacki D, Perry TN, Herrero Del Valle A, Vázquez-Laslop N, Sachs MS, Cruz-Vera LR, Innis CA
Nat Commun (2021) 12 [ Pubmed: 34504068 DOI: 10.1038/s41467-021-25663-8 ]
Image sets:
CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ADP-AlF4(main class)
Resolution: 4.26 Å
EM Method: Helical reconstruction
Fitted PDBs: 7niq
Q-score: 0.304
Yu Q, Herrero Del Valle A, Singh R, Modis Y
Nat Commun (2021) 12 pp. 6668-6668 [ Pubmed: 34795277 DOI: doi:10.1038/s41467-021-27062-5 ]
- Rna (RNA from Pseudomonas virus phi6)
- Interferon-induced helicase c domain-containing protein (Protein from Mus musculus)
- Interferon-induced helicase c domain-containing protein (Complex from Mus musculus)
- M854k mda5-dsrna filament in complex with adp-alf4(major class) (2 MDa, Complex from Mus musculus)
- Rna (Complex from Mus musculus)
CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ADP-AlF4(minor class)
Yu Q, Herrero Del Valle A, Singh R, Modis Y
Nat Commun (2021) 12 pp. 6668-6668 [ Pubmed: 34795277 DOI: doi:10.1038/s41467-021-27062-5 ]
- Rna (RNA from Pseudomonas virus phi6)
- Interferon-induced helicase c domain-containing protein (Protein from Mus musculus)
- Interferon-induced helicase c domain-containing protein (Complex from Mus musculus)
- Rna (Complex from Mus musculus)
- M854k mda5-dsrna filament in complex with adp-alf4(major class) (2 MDa, Complex)
CryoEM structure of the MDA5-dsRNA filament in complex with ADP with 92-degree helical twist
Yu Q, Herrero Del Valle A, Singh R, Modis Y
Nat Commun (2021) 12 pp. 6668-6668 [ Pubmed: 34795277 DOI: doi:10.1038/s41467-021-27062-5 ]
- Rna (Complex from Pseudomonas virus phi6)
- Rna (RNA from Pseudomonas virus phi6)
- Interferon-induced helicase c domain-containing protein (Protein from Mus musculus)
- Mda5-dsrna filament in complex with adp (30 MDa, Complex)
- Interferon-induced helicase c domain-containing protein (Complex from Mus musculus)
CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ATP
Yu Q, Herrero Del Valle A, Singh R, Modis Y
Nat Commun (2021) 12 [ DOI: 10.1038/s41467-021-27062-5 Pubmed: 34795277 ]
Image sets:
CryoEM structure of the MDA5-dsRNA filament in complex with ADP with 88-degree helical twist
Yu Q, Herrero Del Valle A, Singh R, Modis Y
Nat Commun (2021) 12 pp. 6668-6668 [ Pubmed: 34795277 DOI: doi:10.1038/s41467-021-27062-5 ]
- Rna (RNA from synthetic construct)
- Interferon-induced helicase c domain-containing protein (Protein from Mus musculus)
- Mda5-dsrna filament in complex with adp (30 MDa, Complex)
- Interferon-induced helicase c domain-containing protein (Complex from Mus musculus)
- Rna (Complex from synthetic construct)
CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ATP
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 7bkp
Q-score: 0.584
Yu Q, Herrero Del Valle A, Singh R, Modis Y
Nat Commun (2021) 12 pp. 6668-6668 [ Pubmed: 34795277 DOI: doi:10.1038/s41467-021-27062-5 ]
- Rna (Complex from Pseudomonas virus phi6)
- Rna (5'-r(p*cp*up*cp*up*cp*cp*up*cp*gp*gp*cp*up*up*g)-3') (4 kDa, RNA from Pseudomonas virus phi6)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Interferon-induced helicase c domain-containing protein (Complex from Mus musculus)
- Rna (5'-r(p*cp*ap*ap*gp*cp*cp*gp*ap*gp*gp*ap*gp*ap*g)-3') (4 kDa, RNA from Pseudomonas virus phi6)
- Zinc ion (65 Da, Ligand)
- M854k mda5-dsrna filament in complex with atp (1 MDa, Complex)
- Interferon-induced helicase c domain-containing protein 1 (116 kDa, Protein from Mus musculus)
WT MDA5-dsRNA filaments in complex with ADP
Yu Q, Herrero Del Valle A, Singh R, Modis Y
Nat Commun (2021) 12 [ DOI: 10.1038/s41467-021-27062-5 Pubmed: 34795277 ]
Image sets:
Disease variant M854K MDA5-dsRNA filaments in complex with ADP-AlF4
Yu Q, Herrero Del Valle A, Singh R, Modis Y
Nat Commun (2021) 12 [ DOI: 10.1038/s41467-021-27062-5 Pubmed: 34795277 ]
Image sets:
Cryo-EM structure of an Escherichia coli TnaC-ribosome complex stalled in response to L-tryptophan
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7o19
Q-score: 0.555
van der Stel AX, Gordon ER, Sengupta A, Martinez AK, Klepacki D, Perry TN, Herrero Del Valle A, Vazquez-Laslop N, Sachs MS, Cruz-Vera LR, Innis CA
Nat Commun (2021) 12 pp. 5340-5340 [ DOI: doi:10.1038/s41467-021-25663-8 Pubmed: 34504068 ]
- Ribosomal rna 16s (497 kDa, RNA from Escherichia coli K-12)
- 30s ribosomal protein s8 (14 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s10 (11 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l3 (22 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l19 (13 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l22 (12 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l35 (7 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l33 (6 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s5 (17 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l2 (29 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s3 (26 kDa, Protein from Escherichia coli K-12)
- 30s subunit (Complex from Escherichia coli K-12)
- 50s ribosomal protein l28 (9 kDa, Protein from Escherichia coli K-12)
- 70s ribosome stalled during translation of tnac with pro24 in the p-site. (Complex from Escherichia coli K-12)
- 50s ribosomal protein l13 (16 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l21 (11 kDa, Protein from Escherichia coli K-12)
- Water (18 Da, Ligand)
- 50s ribosomal protein l9 (15 kDa, Protein from Escherichia coli K-12)
- 50s subunit (Complex from Escherichia coli K-12)
- P-site trna-pro - tnac nascent chain (Complex from Escherichia coli K-12)
- 30s ribosomal protein s14 (11 kDa, Protein from Escherichia coli K-12)
- Tryptophanase leader peptide (2 kDa, Protein from Escherichia coli K-12)
- Zinc ion (65 Da, Ligand)
- Tryptophan (204 Da, Ligand)
- 30s ribosomal protein s7 (20 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l23 (11 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l4 (22 kDa, Protein from Escherichia coli K-12)
- Mrna (2 kDa, RNA from Escherichia coli K-12)
- 50s ribosomal protein l30 (6 kDa, Protein from Escherichia coli K-12)
- Mrna (Complex from Escherichia coli K-12)
- 50s ribosomal protein l24 (11 kDa, Protein from Escherichia coli K-12)
- Magnesium ion (24 Da, Ligand)
- P-site trna-pro (24 kDa, RNA from Escherichia coli K-12)
- Ribosomal rna 5s (38 kDa, RNA from Escherichia coli K-12)
- 30s ribosomal protein s11 (13 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s17 (9 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s9 (14 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s2 (26 kDa, Protein from Escherichia coli K-12)
- Ribosomal rna 23s (939 kDa, RNA from Escherichia coli K-12)
- 30s ribosomal protein s6 (15 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s13 (13 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s21 (8 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l17 (14 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l32 (6 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l31 (7 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s15 (10 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l25 (10 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s16 (9 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s19 (10 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l20 (13 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l27 (9 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s20 (9 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l5 (20 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l15 (15 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l36 (4 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s18 (9 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l14 (13 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l29 (7 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l34 (5 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s4 (23 kDa, Protein from Escherichia coli K-12)
- 30s ribosomal protein s12 (13 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l6 (18 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l16 (15 kDa, Protein from Escherichia coli K-12)
- 50s ribosomal protein l18 (12 kDa, Protein from Escherichia coli K-12)