Cryo-EM structure of the I923V MDA5-dsRNA filament without nucleotide
Resolution: 3.35 Å
EM Method: Helical reconstruction
Fitted PDBs: 9f0j
Q-score: 0.446
Singh R, Herrero del Valle A, Joiner JD, Zwaagstra M, Ferguson BJ, van Kuppeveld FJM, Modis Y
bioRxiv (2024) [ DOI: doi:10.1101/2024.10.03.616466 ]
- Double stranded rna (Complex from Mus musculus)
- Rna (5'-uccaugcgcaugacg-3') (4 kDa, RNA from Mus musculus)
- Zinc ion (65 Da, Ligand)
- Rna (5'-cgucaugcgcaugga-3') (4 kDa, RNA from Mus musculus)
- Mouse mda5 i923v (Complex from Mus musculus)
- Interferon-induced helicase c domain-containing protein 1 (116 kDa, Protein from Mus musculus)
- Mouse mda5 i923v in complex with double stranded rna (28 MDa, Complex)
Cryo-EM structure of the I923V MDA5-dsRNA filament with ADP-AlF4 bound and 81-degree helical twist
Resolution: 3.67 Å
EM Method: Helical reconstruction
Fitted PDBs: 9f1u
Q-score: 0.335
Singh R, Herrero del Valle A, Joiner JD, Zwaagstra M, Ferguson BJ, van Kuppeveld FJM, Modis Y
bioRxiv (2024) [ DOI: doi:10.1101/2024.10.03.616466 ]
- Double stranded rna (Complex from Mus musculus)
- Rna (5'-r(p*cp*ap*ap*gp*cp*cp*gp*ap*gp*gp*ap*gp*ap*u)-3') (4 kDa, RNA from Mus musculus)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Rna (5'-r(p*ap*up*cp*up*cp*cp*up*cp*gp*gp*cp*up*up*g)-3') (4 kDa, RNA from Mus musculus)
- Mouse mda5 i923v (Complex from Mus musculus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Interferon-induced helicase c domain-containing protein 1 (116 kDa, Protein from Mus musculus)
- Mouse mda5 i923v in complex with double stranded rna (28 MDa, Complex)
Cryo-EM structure of the I923V MDA5-dsRNA filament with ADP-AlF4 bound and 73-degree helical twist
Resolution: 3.86 Å
EM Method: Helical reconstruction
Fitted PDBs: 9f2l
Q-score: 0.385
Singh R, Herrero del Valle A, Joiner JD, Zwaagstra M, Ferguson BJ, van Kuppeveld FJM, Modis Y
bioRxiv (2024) [ DOI: doi:10.1101/2024.10.03.616466 ]
- Double stranded rna (Complex from Mus musculus)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Mouse mda5 i923v (Complex from Mus musculus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Rna (5'-r(p*cp*ap*ap*gp*cp*cp*gp*ap*gp*gp*ap*gp*ap*g)-3') (4 kDa, RNA from Mus musculus)
- Interferon-induced helicase c domain-containing protein 1 (116 kDa, Protein from Mus musculus)
- Rna (5'-r(p*cp*up*cp*up*cp*cp*up*cp*gp*gp*cp*up*up*g)-3') (4 kDa, RNA from Mus musculus)
- Mouse mda5 i923v in complex with double stranded rna (28 MDa, Complex)
Cryo-EM structure of the A946T MDA5-dsRNA filament
Resolution: 3.97 Å
EM Method: Helical reconstruction
Fitted PDBs: 9f3p
Q-score: 0.348
Singh R, Herrero del Valle A, Joiner JD, Zwaagstra M, Ferguson BJ, van Kuppeveld FJM, Modis Y
bioRxiv (2024) [ DOI: doi:10.1101/2024.10.03.616466 ]
- Double stranded rna (Complex from Mus musculus)
- Rna (5'-r(p*up*cp*up*cp*cp*up*cp*gp*gp*cp*up*up*gp*ap*c)-3') (4 kDa, RNA from Mus musculus)
- Mouse mda5 a946t (Complex from Mus musculus)
- Zinc ion (65 Da, Ligand)
- Mouse mda5 a946t in complex with double stranded rna (28 MDa, Complex)
- Interferon-induced helicase c domain-containing protein 1 (116 kDa, Protein from Mus musculus)
- Rna (5'-r(p*gp*up*cp*ap*ap*gp*cp*cp*gp*ap*gp*gp*ap*gp*a)-3') (4 kDa, RNA from Mus musculus)
CryoEM structure of the MDA5-dsRNA filament in complex with ADP with 92-degree helical twist
Yu Q, Herrero Del Valle A, Singh R, Modis Y
Nat Commun (2021) 12 pp. 6668-6668 [ DOI: doi:10.1038/s41467-021-27062-5 Pubmed: 34795277 ]
- Rna (Complex from Pseudomonas virus phi6)
- Mda5-dsrna filament in complex with adp (30 MDa, Complex)
- Interferon-induced helicase c domain-containing protein (Protein from Mus musculus)
- Rna (RNA from Pseudomonas virus phi6)
- Interferon-induced helicase c domain-containing protein (Complex from Mus musculus)
CryoEM structure of the MDA5-dsRNA filament in complex with ADP with 88-degree helical twist
Yu Q, Herrero Del Valle A, Singh R, Modis Y
Nat Commun (2021) 12 pp. 6668-6668 [ DOI: doi:10.1038/s41467-021-27062-5 Pubmed: 34795277 ]
- Mda5-dsrna filament in complex with adp (30 MDa, Complex)
- Rna (Complex from synthetic construct)
- Interferon-induced helicase c domain-containing protein (Protein from Mus musculus)
- Rna (RNA from synthetic construct)
- Interferon-induced helicase c domain-containing protein (Complex from Mus musculus)