GCGR-Gs signaling complex bound to a designed glucagon derivative
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6wpw
Q-score: 0.518
Hilger D, Kumar KK, Hu H, Pedersen MF, O'Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK
Science (2020) 369 [ DOI: doi:10.1126/science.aba3373 Pubmed: 32732395 ]
- Designed glucagon derivative (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gcgr (Complex from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Gcgr-gs signaling complex bound to a designed glucagon derivative (163 kDa, Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Glucagon derivative zp3780 (3 kDa, Protein from synthetic construct)
- Gs (Complex from Homo sapiens)
- Glucagon receptor (56 kDa, Protein from Homo sapiens)
human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6os9
Q-score: 0.51
Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G
Nature (2019) 572 pp. 80-85 [ DOI: doi:10.1038/s41586-019-1337-6 Pubmed: 31243364 ]
- Neurotensin receptor type 1 (48 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Jmv449 (762 Da, Protein from synthetic construct)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Hntsr1-gi1 complex in canonical conformation (c state) (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in non-canonical conformation (NC state)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6osa
Q-score: 0.497
Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G
Nature (2019) 572 pp. 80-85 [ DOI: doi:10.1038/s41586-019-1337-6 Pubmed: 31243364 ]
- Neurotensin receptor type 1 (48 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Jmv449 (762 Da, Protein from synthetic construct)
- Hntsr1-gi1 complex in non-canonical conformation (nc state) (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)