Cannabinoid Receptor 1-G Protein Complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6n4b
Q-score: 0.506
Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, Skiniotis G
Cell (2019) 176 pp. 448- [ Pubmed: 30639101 DOI: doi:10.1016/j.cell.2018.11.040 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Cannabinoid receptor 1-g protein complex (Complex from Homo sapiens)
- Cannabinoid receptor 1 (55 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Methyl n-{1-[(4-fluorophenyl)methyl]-1h-indazole-3-carbonyl}-3-methyl-l-valinate (397 Da, Ligand)
Mu Opioid Receptor-Gi Protein Complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6dde
Q-score: 0.407
Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK
Nature (2018) 558 pp. 547-552 [ DOI: doi:10.1038/s41586-018-0219-7 Pubmed: 29899455 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Damgo (513 Da, Protein from Homo sapiens)
- Ternary complex of damgo-activated mu-type opioid receptor with heterotrimeric gi, further stabilized by addition of scfv-16 (130 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Mu-type opioid receptor (39 kDa, Protein from Mus musculus)
Mu Opioid Receptor-Gi Protein Complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6ddf
Q-score: 0.416
Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK
Nature (2018) 558 pp. 547-552 [ DOI: doi:10.1038/s41586-018-0219-7 Pubmed: 29899455 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Ternary complex of damgo-activated mu-type opioid receptor with heterotrimeric gi (120 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Damgo (513 Da, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Mu-type opioid receptor (39 kDa, Protein from Mus musculus)