Structure of human mitochondrial RNA polymerase in complex with IMT inhibitor.
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7a8p
Q-score: 0.463
Bonekamp NA, Peter B, Hillen HS, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel MS, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson CM, Larsson NG
Nature (2020) 588 pp. 712-716 [ Pubmed: 33328633 DOI: doi:10.1038/s41586-020-03048-z ]
- Human polrmt (lacking residues 1-104) in complex with imt inhibitor. (128 kDa, Complex from Homo sapiens)
- (3~{r})-1-[(2~{r})-2-[4-(2-chloranyl-4-fluoranyl-phenyl)-2-oxidanylidene-chromen-7-yl]oxypropanoyl]piperidine-3-carboxylic acid (473 Da, Ligand)
- Dna-directed rna polymerase, mitochondrial (129 kDa, Protein from Homo sapiens)
Structure of the complete Vaccinia DNA-dependent RNA polymerase complex
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 6rfl
Q-score: 0.572
Grimm C, Hillen HS, Bedenk K, Bartuli J, Neyer S, Zhang Q, Huttenhofer A, Erlacher M, Dienemann C, Schlosser A, Urlaub H, Bottcher B, Szalay AA, Cramer P, Fischer U
Cell (2019) 179 pp. 1537-1550.e19 [ DOI: doi:10.1016/j.cell.2019.11.024 Pubmed: 31835032 ]
- Dna-directed rna polymerase 35 kda subunit (35 kDa, Protein from Vaccinia virus GLV-1h68)
- Complete vaccinia dna-dependent rna polymerase complex (Complex)
- Dna-dependent rna polymerase subunit rpo132 (133 kDa, Protein from Vaccinia virus GLV-1h68)
- Nucleoside triphosphate phosphohydrolase-i (72 kDa, Protein from Vaccinia virus GLV-1h68)
- Putative h4l rna polymerase-associated transcription factor rap94 (93 kDa, Protein from Vaccinia virus GLV-1h68)
- Virion core protein (14 kDa, Protein from Vaccinia virus GLV-1h68)
- Dna-directed rna polymerase 30 kda polypeptide (30 kDa, Protein from Vaccinia virus GLV-1h68)
- Dna-dependent rna polymerase subunit rpo7 (7 kDa, Protein from Vaccinia virus GLV-1h68)
- Water (18 Da, Ligand)
- Dna-dependent rna polymerase subunit rpo18 (17 kDa, Protein from Vaccinia virus GLV-1h68)
- Small subunit of mrna capping enzyme (33 kDa, Protein from Vaccinia virus GLV-1h68)
- Dna-directed rna polymerase subunit (21 kDa, Protein from Vaccinia virus GLV-1h68)
- Dna-directed rna polymerase 19 kda subunit (19 kDa, Protein from Vaccinia virus GLV-1h68)
- Chr17.trna16-glnttg (23 kDa, RNA from Homo sapiens)
- Vaccinia dna-dependent rna polymerase complex (Complex from Vaccinia virus GLV-1H68)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Large subunit of mrna capping enzyme (96 kDa, Protein from Vaccinia virus GLV-1h68)
- Dna-dependent rna polymerase subunit rpo147 (146 kDa, Protein from Vaccinia virus GLV-1h68)
- Rna (Complex from Homo sapiens)
- Transcription factor vetf 82kda large subunit (82 kDa, Protein from Vaccinia virus GLV-1h68)