Structure of human alpha-2/delta-1 with mirogabalin
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8if3
Q-score: 0.447
Kozai D, Numoto N, Nishikawa K, Kamegawa A, Kawasaki S, Hiroaki Y, Irie K, Oshima A, Hanzawa H, Shimada K, Kitano Y, Fujiyoshi Y
J Mol Biol (2023) 435 pp. 168049-168049 [ Pubmed: 36933823 DOI: doi:10.1016/j.jmb.2023.168049 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (140 kDa, Cellular component from Homo sapiens)
- 2-[(1r,5s,6s)-6-(aminomethyl)-3-ethyl-6-bicyclo[3.2.0]hept-3-enyl]acetic acid (209 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
Structure of human alpha-2/delta-1 without mirogabalin
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8if4
Q-score: 0.41
Kozai D, Numoto N, Nishikawa K, Kamegawa A, Kawasaki S, Hiroaki Y, Irie K, Oshima A, Hanzawa H, Shimada K, Kitano Y, Fujiyoshi Y
J Mol Biol (2023) 435 pp. 168049-168049 [ Pubmed: 36933823 DOI: doi:10.1016/j.jmb.2023.168049 ]
Cryo-EM structure of MrgD-Gi complex with beta-alanine
Suzuki S, Iida M, Hiroaki Y, Tanaka K, Kawamoto A, Kato T, Oshima A
Communications Biology (2022) [ DOI: 10.1038/s42003-022-03668-3 ]
Image sets:
Cryo-EM structure of MrgD-Gi complex with beta-alanine
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7y12
Q-score: 0.519
Suzuki S, Iida M, Hiroaki Y, Tanaka K, Kawamoto A, Kato T, Oshima A
Commun Biol (2022) 5 pp. 707-707 [ DOI: doi:10.1038/s42003-022-03668-3 Pubmed: 35840655 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Mus musculus)
- Scfv16 (31 kDa, Protein from synthetic construct)
- Palmitic acid (256 Da, Ligand)
- Scfv16 (Complex)
- Soluble cytochrome b562,mas-related g-protein coupled receptor member d (50 kDa, Protein from Homo sapiens)
- G(i) subunit alpha-1,mas-related g-protein coupled receptor member d (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Mus musculus)
- Beta-alanine (89 Da, Ligand)
- Beta-alanine bound mrgd-gi complex with the scfv16 (Complex from Homo sapiens)
- Subunit beta-1,subunit gamma-2 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of apo-state MrgD-Gi complex (local)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7y13
Q-score: 0.512
Suzuki S, Iida M, Hiroaki Y, Tanaka K, Kawamoto A, Kato T, Oshima A
Commun Biol (2022) 5 pp. 707-707 [ DOI: doi:10.1038/s42003-022-03668-3 Pubmed: 35840655 ]
- Water (18 Da, Ligand)
- Soluble cytochrome b562,mas-related g-protein coupled receptor member d (Complex from Homo sapiens)
- Soluble cytochrome b562,mas-related g-protein coupled receptor member d (50 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
Cryo-EM structure of MrgD-Gi complex with beta-alanine (local)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7y14
Q-score: 0.494
Suzuki S, Iida M, Hiroaki Y, Tanaka K, Kawamoto A, Kato T, Oshima A
Commun Biol (2022) 5 pp. 707-707 [ DOI: doi:10.1038/s42003-022-03668-3 Pubmed: 35840655 ]
- Beta-alanine (89 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Beta-alanine bound mrgd-gi complex with the scfv16 (Complex from Homo sapiens)
- Soluble cytochrome b562,mas-related g-protein coupled receptor member d (50 kDa, Protein from Homo sapiens)
Cryo-EM structure of apo-state MrgD-Gi complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7y15
Q-score: 0.552
Suzuki S, Iida M, Hiroaki Y, Tanaka K, Kawamoto A, Kato T, Oshima A
Commun Biol (2022) 5 pp. 707-707 [ DOI: doi:10.1038/s42003-022-03668-3 Pubmed: 35840655 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Mus musculus)
- Scfv16 (31 kDa, Protein from synthetic construct)
- Palmitic acid (256 Da, Ligand)
- Scfv16 (Complex)
- Soluble cytochrome b562,mas-related g-protein coupled receptor member d (50 kDa, Protein from Homo sapiens)
- G(i) subunit alpha-1,mas-related g-protein coupled receptor member d (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Mus musculus)
- Subunit beta-1,subunit gamma-2 (Complex from synthetic construct)
- Mrgd-gi complex with the scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
crystal structure of AQP4 bound to AZA
Kamegawa A, Hiroaki Y, Tani K, Fujiyoshi Y
Microscopy (2016) 65 pp. 177-184 [ Pubmed: 26908838 DOI: doi:10.1093/jmicro/dfv368 ]
Gonen T, Cheng Y, Sliz P, Hiroaki Y, Fujiyoshi Y, Harrison SC, Walz T
Nature (2005) 438 pp. 633-638 [ Pubmed: 16319884 DOI: doi:10.1038/nature04321 ]
- Aquaporin-0 (120 kDa, Protein from Ovis aries)
- Mammalian aquaporin-0 (sheep) (120 kDa, Sample)