Cryo-EM structure of HIV-1 Env trimer BG505 SOSIP.664 in complex with CD4bs antibody Ab1573
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7tfo
Q-score: 0.359
Yang Z, Dam KA, Bridges MD, Hoffmann MAG, DeLaitsch AT, Gristick HB, Escolano A, Gautam R, Martin MA, Nussenzweig MC, Hubbell WL, Bjorkman PJ
Nat Commun (2022) 13 pp. 732-732 [ DOI: doi:10.1038/s41467-022-28424-3 Pubmed: 35136084 ]
- Bg505 sosip.664 in complex with cd4bs antibody ab1573 (Complex from Macaca mulatta)
- Envelope glycoprotein bg505 sosip.664 - gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein bg505 sosip.664 - gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Cd4 binding site antibody ab1573 - fab heavy chain (24 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cd4 binding site antibody ab1573 - fab light chain (23 kDa, Protein from Macaca mulatta)
Cryo-EM structure of CD4bs antibody Ab1303 in complex with HIV-1 Env trimer BG505 SOSIP.664
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7tfn
Q-score: 0.437
Yang Z, Dam KA, Bridges MD, Hoffmann MAG, DeLaitsch AT, Gristick HB, Escolano A, Gautam R, Martin MA, Nussenzweig MC, Hubbell WL, Bjorkman PJ
Nat Commun (2022) 13 pp. 732-732 [ DOI: doi:10.1038/s41467-022-28424-3 Pubmed: 35136084 ]
- Cd4 binding site antibody fab ab1303 - light chain (23 kDa, Protein from Macaca mulatta)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Envelope glycoprotein bg505 sosip.664 - gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein bg505 sosip.664 - gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Anti-hiv-1 cd4bs antibody fab ab1303 - heavy chain (25 kDa, Protein from Macaca mulatta)
- Cryo-em map of ab1303 in complex with bg505 sosip.664 env trimer (local resolution refined) (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 6xcm
Q-score: 0.456
Barnes CO, West Jr AP, Huey-Tubman KE, Hoffmann MAG, Sharaf NG, Hoffman PR, Koranda N, Gristick HB, Gaebler C, Muecksch F, Lorenzi JCC, Finkin S, Hagglof T, Hurley A, Millard KG, Weisblum Y, Schmidt F, Hatziioannou T, Bieniasz PD, Caskey M, Robbiani DF, Nussenzweig MC, Bjorkman PJ
Cell (2020) 182 pp. 828- [ DOI: doi:10.1016/j.cell.2020.06.025 Pubmed: 32645326 ]
- Sars-cov-2 s 2p trimer complexed with monoclonal fab fragments from neutralizing antibody c105 (700 kDa, Complex)
- C105 fab light chain (22 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike glycoprotein 2p trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- Neutralizing antibody c105 fab (Complex from Homo sapiens)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- C105 fab heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.66 Å
EM Method: Single-particle
Fitted PDBs: 6xcn
Q-score: 0.423
Barnes CO, West Jr AP, Huey-Tubman KE, Hoffmann MAG, Sharaf NG, Hoffman PR, Koranda N, Gristick HB, Gaebler C, Muecksch F, Lorenzi JCC, Finkin S, Hagglof T, Hurley A, Millard KG, Weisblum Y, Schmidt F, Hatziioannou T, Bieniasz PD, Caskey M, Robbiani DF, Nussenzweig MC, Bjorkman PJ
Cell (2020) 182 pp. 828- [ DOI: doi:10.1016/j.cell.2020.06.025 Pubmed: 32645326 ]
- C105 fab light chain (22 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike glycoprotein 2p trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- Neutralizing antibody c105 fab (Complex from Homo sapiens)
- Sars-cov-2 s 2p trimer complexed with monoclonal fab fragments from neutralizing antibody c105 (750 kDa, Complex)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- C105 fab heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)