EM map Of Respiratory Syncytial Virus Polymerase in complex with JNJ-2729
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 9c7y
Q-score: 0.502
Tran MT, Grosse S, Carbajo RJ, Jacoby E, Yin Y, Yu X, Martinez C, Stoops B, Cooymans L, Hu L, Lutter FH, Pieters S, Tan E, Alcazar J, Roymans D, van Vlijmen H, Rigaux P, Sharma S, Jonckers THM
Acs Med.Chem.Lett. (2024) 15 pp. 1549-1558 [ Pubmed: 39291020 DOI: doi:10.1021/acsmedchemlett.4c00272 ]
- Respiratory syncytial virus polymerase in complex with non-nucleoside inhibitor (Complex from Human respiratory syncytial virus A2)
- (2s)-1,1,1-trifluoro-2-[5-fluoro-6-(4-fluorophenyl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl]-3-[(4m)-4-(8-methoxyquinolin-6-yl)-1h-1,2,3-triazol-1-yl]propan-2-ol (585 Da, Ligand)
- Phosphoprotein (29 kDa, Protein from Human respiratory syncytial virus A2)
- Rna-directed rna polymerase l (254 kDa, Protein from Human respiratory syncytial virus A2)
Cryo EM map of full length PLC gamma 2
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 8jqg
Q-score: 0.384
Shin YC, Plummer-Medeiros AM, Mungenast A, Choi HW, TenDyke K, Zhu X, Shepard J, Sanders K, Zhuang N, Hu L, Qian D, Song K, Xu C, Wang J, Poda SB, Liao M, Chen Y
Sci Adv (2024) 10 pp. eadn6037-eadn6037 [ DOI: doi:10.1126/sciadv.adn6037 Pubmed: 39612343 ]
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (148 kDa, Protein from Homo sapiens)
- Plcg2 and fgfr1 (147 kDa, Complex from Homo sapiens)
Cryo EM map of full length PLC gamma 2 in autoinhibition state
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8jqh
Q-score: 0.298
Shin YC, Plummer-Medeiros AM, Mungenast A, Choi HW, TenDyke K, Zhu X, Shepard J, Sanders K, Zhuang N, Hu L, Qian D, Song K, Xu C, Wang J, Poda SB, Liao M, Chen Y
Sci Adv (2024) 10 pp. eadn6037-eadn6037 [ DOI: doi:10.1126/sciadv.adn6037 Pubmed: 39612343 ]
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (148 kDa, Protein from Homo sapiens)
- Plcg2 and fgfr1 (147 kDa, Complex from Homo sapiens)
Cryo EM map of full length PLC gamma 2 and FGFR1 Kinase Domain
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8jqi
Q-score: 0.273
Shin YC, Plummer-Medeiros AM, Mungenast A, Choi HW, TenDyke K, Zhu X, Shepard J, Sanders K, Zhuang N, Hu L, Qian D, Song K, Xu C, Wang J, Poda SB, Liao M, Chen Y
Sci Adv (2024) 10 pp. eadn6037-eadn6037 [ DOI: doi:10.1126/sciadv.adn6037 Pubmed: 39612343 ]
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (148 kDa, Protein from Homo sapiens)
- Fibroblast growth factor receptor 1 (91 kDa, Protein from Homo sapiens)
- Plcg2 and fgfr1 (147 kDa, Complex from Homo sapiens)
Cryo-EM structure of mClC-3 with AMP
Wan Y, Guo S, Zhen W, Xu L, Chen X, Liu F, Shen Y, Liu S, Hu L, Wang X, Ye F, Wang Q, Wen H, Yang F
Nat Commun (2024) 15 pp. 6654-6654 [ Pubmed: 39107281 DOI: doi:10.1038/s41467-024-50975-w ]
- H(+)/cl(-) exchange transporter 3 (90 kDa, Protein from Mus musculus)
- Mclc-3 with amp (Complex from Mus musculus)
- Water (18 Da, Ligand)
- Adenosine monophosphate (347 Da, Ligand)
Cryo-EM structure of apo state mClC-3
Wan Y, Guo S, Zhen W, Xu L, Chen X, Liu F, Shen Y, Liu S, Hu L, Wang X, Ye F, Wang Q, Wen H, Yang F
Nat Commun (2024) 15 pp. 6654-6654 [ Pubmed: 39107281 DOI: doi:10.1038/s41467-024-50975-w ]
- Apo state of mclc-3 (Complex from Mus musculus)
- Chloride ion (35 Da, Ligand)
- H(+)/cl(-) exchange transporter 3 (90 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
Cryo-EM structure of mClC-3 with ATP
Wan Y, Guo S, Zhen W, Xu L, Chen X, Liu F, Shen Y, Liu S, Hu L, Wang X, Ye F, Wang Q, Wen H, Yang F
Nat Commun (2024) 15 pp. 6654-6654 [ Pubmed: 39107281 DOI: doi:10.1038/s41467-024-50975-w ]
- Water (18 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Mclc-3 with atp (Complex from Mus musculus)
- H(+)/cl(-) exchange transporter 3 (90 kDa, Protein from Mus musculus)
Cryo-EM structure of mClC-3 with ADP
Wan Y, Guo S, Zhen W, Xu L, Chen X, Liu F, Shen Y, Liu S, Hu L, Wang X, Ye F, Wang Q, Wen H, Yang F
Nat Commun (2024) 15 pp. 6654-6654 [ Pubmed: 39107281 DOI: doi:10.1038/s41467-024-50975-w ]
- Mclc-3 with adp (Complex from Mus musculus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- H(+)/cl(-) exchange transporter 3 (90 kDa, Protein from Mus musculus)
Cryo-EM structure of apo state mClC-3_I607T
Wan Y, Guo S, Zhen W, Xu L, Chen X, Liu F, Shen Y, Liu S, Hu L, Wang X, Ye F, Wang Q, Wen H, Yang F
Nat Commun (2024) 15 pp. 6654-6654 [ Pubmed: 39107281 DOI: doi:10.1038/s41467-024-50975-w ]
- Apo state of mclc-3_i607t (Complex from Mus musculus)
- H(+)/cl(-) exchange transporter 3 (90 kDa, Protein from Mus musculus)
Cryo-EM structure of mClC-3_I607T with ATP
Wan Y, Guo S, Zhen W, Xu L, Chen X, Liu F, Shen Y, Liu S, Hu L, Wang X, Ye F, Wang Q, Wen H, Yang F
Nat Commun (2024) 15 pp. 6654-6654 [ Pubmed: 39107281 DOI: doi:10.1038/s41467-024-50975-w ]
- H(+)/cl(-) exchange transporter 3 (90 kDa, Protein from Mus musculus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Mclc-3_i607t with atp (Complex from Mus musculus)