Structure of EBOV GP lacking the mucin-like domain with 1C11 scFv and 1C3 Fab bound
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 7swd
Q-score: 0.449
Milligan JC, Davis CW, Yu X, Ilinykh PA, Huang K, Halfmann PJ, Cross RW, Borisevich V, Agans KN, Geisbert JB, Chennareddy C, Goff AJ, Piper AE, Hui S, Shaffer KCL, Buck T, Heinrich ML, Branco LM, Crozier I, Holbrook MR, Kuhn JH, Kawaoka Y, Glass PJ, Bukreyev A, Geisbert TW, Worwa G, Ahmed R, Saphire EO
Cell (2022) 185 pp. 995-1007.e18 [ DOI: doi:10.1016/j.cell.2022.02.023 Pubmed: 35303429 ]
- Complex of ebov gp lacking the mucin-like-domain with 1c11 scfv and 1c3 fab (300 kDa, Complex from Homo sapiens)
- Virion spike glycoprotein gp1 (31 kDa, Protein from Ebola virus - Gabon (1994-1997))
- Virion spike glycoprotein gp2 (10 kDa, Protein from Zaire ebolavirus)
- 1c3 heavy chain (13 kDa, Protein from Homo sapiens)
- 1c11 scfv (26 kDa, Protein from Homo sapiens)
- 1c3 light chain (12 kDa, Protein from Homo sapiens)
EBOV GP bound to rEBOV-442 and rEBOV-515 Fabs
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7m8l
Q-score: 0.433
Gilchuk P, Murin CD, Cross RW, Ilinykh PA, Huang K, Kuzmina N, Borisevich V, Agans KN, Geisbert JB, Zost SJ, Nargi RS, Sutton RE, Suryadevara N, Bombardi RG, Carnahan RH, Bukreyev A, Geisbert TW, Ward AB, Crowe Jr JE
Cell (2021) 184 pp. 5593-5607.e18 [ Pubmed: 34715022 DOI: doi:10.1016/j.cell.2021.09.035 ]
- Virion spike glycoprotein 2 (22 kDa, Protein from Ebola virus)
- Rebov-442 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Rebov-515 fab light chain (23 kDa, Protein from Homo sapiens)
- Complex of mucin deleted ebola virus gp (makona variant) bound to rebov-442 and rebov-515 fabs (Complex from Ebola virus)
- Rebov-442 fab light chain (23 kDa, Protein from Homo sapiens)
- Rebov-515 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein 1 (34 kDa, Protein from Ebola virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
BDBV-289 bound to EBOV GPdMuc Makona
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7kej
Q-score: 0.451
Murin CD, Gilchuk P, Ilinykh PA, Huang K, Kuzmina N, Shen X, Bruhn JF, Bryan AL, Davidson E, Doranz BJ, Williamson LE, Copps J, Alkutkar T, Flyak AI, Bukreyev A, Crowe Jr JE, Ward AB
Cell Rep (2021) 35 pp. 108984-108984 [ Pubmed: 33852862 DOI: doi:10.1016/j.celrep.2021.108984 ]
- Virion spike glycoprotein (22 kDa, Protein from Zaire ebolavirus)
- Antibody fab light chain (lc) bdbv-289 (24 kDa, Protein from Homo sapiens)
- Complex of ebola virus gp (mucin-deleted makona strain) bound to bdbv-289 fab (Complex from Homo sapiens)
- Antibody fab heavy chain (hc) bdbv-289 (26 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein (34 kDa, Protein from Ebola virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-442 and EBOV-515
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7kfb
Q-score: 0.409
Murin CD, Gilchuk P, Ilinykh PA, Huang K, Kuzmina N, Shen X, Bruhn JF, Bryan AL, Davidson E, Doranz BJ, Williamson LE, Copps J, Alkutkar T, Flyak AI, Bukreyev A, Crowe Jr JE, Ward AB
Cell Rep (2021) 35 pp. 108984-108984 [ Pubmed: 33852862 DOI: doi:10.1016/j.celrep.2021.108984 ]
- Antibody fab ebov-442 (Complex from Homo sapiens)
- Virion spike glycoprotein 2 (22 kDa, Protein from Ebola virus)
- Ebola virus gp (mucin deleted, makona strain) (Complex from Ebola virus)
- Antibody fab ebov-442 heavy chain (25 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein 1 (34 kDa, Protein from Ebola virus)
- Ebola virus gp (mucin deleted, makona strain) bound to antibody fab ebov-442 and ebov-515 (Complex from Ebola virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Antibody fab ebov-442 light chain (23 kDa, Protein from Homo sapiens)
Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-437 and EBOV-515
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7kfh
Q-score: 0.413
Murin CD, Gilchuk P, Ilinykh PA, Huang K, Kuzmina N, Shen X, Bruhn JF, Bryan AL, Davidson E, Doranz BJ, Williamson LE, Copps J, Alkutkar T, Flyak AI, Bukreyev A, Crowe Jr JE, Ward AB
Cell Rep (2021) 35 pp. 108984-108984 [ Pubmed: 33852862 DOI: doi:10.1016/j.celrep.2021.108984 ]
- Ebola virus gp (mucin deleted, makona strain) bound to antibody fab ebov-437 and ebov-515 (Complex from Homo sapiens)
- Antibody fab ebov-437 heavy chain (25 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein 2 (22 kDa, Protein from Ebola virus)
- Antibody fab ebov-437 light chain (23 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein 1 (34 kDa, Protein from Ebola virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
EBOV GPdMuc Makona bound to rEBOV-548 Fab
Resolution: 3.96 Å
EM Method: Single-particle
Fitted PDBs: 6uye
Q-score: 0.413
Gilchuk P, Murin CD, Milligan JC, Cross RW, Mire CE, Ilinykh PA, Huang K, Kuzmina N, Altman PX, Hui S, Gunn BM, Bryan AL, Davidson E, Doranz BJ, Turner HL, Alkutkar T, Flinko R, Orlandi C, Carnahan R, Nargi R, Bombardi RG, Vodzak ME, Li S, Okoli A, Ibeawuchi M, Ohiaeri B, Lewis GK, Alter G, Bukreyev A, Saphire EO, Geisbert TW, Ward AB, Crowe Jr JE
Immunity (2020) 52 pp. 388-403.e12 [ DOI: doi:10.1016/j.immuni.2020.01.001 Pubmed: 32023489 ]
- Ebola virus, mucin deleted, strain makona (Complex from Ebola virus)
- Complex of ebola virus, mucin deleted, strain makona in complex with rebov-548 fab (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Antibody rebov-548 fab, light chain (11 kDa, Protein from Homo sapiens)
- Sgp (29 kDa, Protein from Ebola virus)
- Antibody rebov-548 fab, heavy chain (14 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein (10 kDa, Protein from Ebola virus)
- Rebov-548 fab (Complex from Homo sapiens)