GluA2 flip Q in complex with TARPgamma2 at pH8, consensus structure of LBD-TMD-TARPgamma2
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 9b5z
Q-score: 0.53
Ivica J, Kejzar N, Ho H, Stockwell I, Kuchtiak V, Scrutton AM, Nakagawa T, Greger IH
Nat Struct Mol Biol (2024) 31 pp. 1601-1613 [ DOI: doi:10.1038/s41594-024-01369-5 Pubmed: 39138332 ]
GluA2 flip Q in complex with TARPgamma2 at pH8, consensus structure of TMD-TARPgamma2
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 9b60
Q-score: 0.553
Ivica J, Kejzar N, Ho H, Stockwell I, Kuchtiak V, Scrutton AM, Nakagawa T, Greger IH
Nat Struct Mol Biol (2024) 31 pp. 1601-1613 [ DOI: doi:10.1038/s41594-024-01369-5 Pubmed: 39138332 ]
GluA2 flip Q in complex with TARPgamma2 at pH5, consensus structure of LBD-TMD-TARPgamma2
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 9b61
Q-score: 0.428
Ivica J, Kejzar N, Ho H, Stockwell I, Kuchtiak V, Scrutton AM, Nakagawa T, Greger IH
Nat Struct Mol Biol (2024) 31 pp. 1601-1613 [ DOI: doi:10.1038/s41594-024-01369-5 Pubmed: 39138332 ]
GluA2 flip Q in complex with TARPgamma2 at pH5, consensus structure of TMD-TARPgamma2
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 9b63
Q-score: 0.507
Ivica J, Kejzar N, Ho H, Stockwell I, Kuchtiak V, Scrutton AM, Nakagawa T, Greger IH
Nat Struct Mol Biol (2024) 31 pp. 1601-1613 [ DOI: doi:10.1038/s41594-024-01369-5 Pubmed: 39138332 ]
Active state homomeric GluA1 AMPA receptor in complex with TARP gamma 3
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8c1p
Q-score: 0.561
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- Cyclothiazide (389 Da, Ligand)
- Water (18 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Homomeric glua1 ampa receptor in complex with tarp gamma 3 (Complex from Rattus)
- Glutamate receptor 1 flip isoform (102 kDa, Protein from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Voltage-dependent calcium channel gamma-3 subunit (35 kDa, Protein from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
Resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8c1q
Q-score: 0.54
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- Water (18 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Homomeric glua1 ampa receptor in complex with tarp gamma 3 (Complex from Rattus)
- Glutamate receptor 1 flip isoform (102 kDa, Protein from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Voltage-dependent calcium channel gamma-3 subunit (35 kDa, Protein from Rattus norvegicus)
Transmembrane domain of active state homomeric GluA1 AMPA receptor in tandem with TARP gamma 3
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 8c2h
Q-score: 0.619
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- Water (18 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Homomeric glua1 ampa receptor in complex with tarp gamma 3 (Complex from Rattus)
- Glutamate receptor 1 flip isoform (102 kDa, Protein from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Voltage-dependent calcium channel gamma-3 subunit (35 kDa, Protein from Rattus norvegicus)
Transmembrane domain of resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8c2i
Q-score: 0.581
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- Water (18 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Homomeric glua1 ampa receptor in complex with tarp gamma 3 (Complex from Rattus)
- Glutamate receptor 1 flip isoform (102 kDa, Protein from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Voltage-dependent calcium channel gamma-3 subunit (35 kDa, Protein from Rattus norvegicus)
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8p3q
Q-score: 0.357
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- Water (18 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Homomeric glua1 ampa receptor in complex with tarp gamma 3 and 1mm quisqualate (Complex from Rattus)
- Voltage-dependent calcium channel gamma-2 subunit (35 kDa, Protein from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Glutamate receptor 2 (98 kDa, Protein from Rattus norvegicus)
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8p3s
Q-score: 0.361
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- Water (18 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Glua2 irr f231a mutant ampa receptor (r/g unedited) in tandem with tarp gamma 2 in complex with 1mm quisqualate (Complex from Rattus norvegicus)
- Voltage-dependent calcium channel gamma-2 subunit (35 kDa, Protein from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Glutamate receptor 2 (98 kDa, Protein from Rattus norvegicus)