Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8sun
Q-score: 0.43
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ Pubmed: 37573365 DOI: doi:10.1038/s41467-023-40410-x ]
- Anoctamin-6 (95 kDa, Protein from Mus musculus)
- 16f (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-hydroxy-3-(trifluoromethyl)pyrido[1,2-a]benzimidazole-4-carbonitrile (277 Da, Ligand)
TMEM16F bound with Niclosamide
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8sur
Q-score: 0.46
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ Pubmed: 37573365 DOI: doi:10.1038/s41467-023-40410-x ]
- Anoctamin-6 (106 kDa, Protein from Mus musculus)
- 5-chloro-n-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide (327 Da, Ligand)
- 16f (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
TMEM16F, with Calcium and PIP2, no inhibitor
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8tag
Q-score: 0.452
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ Pubmed: 37573365 DOI: doi:10.1038/s41467-023-40410-x ]
- 16f (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anoctamin-6 (95 kDa, Protein from Mus musculus)
TMEM16F, with Calcium and PIP2, no inhibitor, Cl2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8tai
Q-score: 0.466
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ Pubmed: 37573365 DOI: doi:10.1038/s41467-023-40410-x ]
- 16f (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anoctamin-6 (95 kDa, Protein from Mus musculus)
TMEM16F, with Calcium and PIP2, no inhibitor, Cl1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8tal
Q-score: 0.454
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ Pubmed: 37573365 DOI: doi:10.1038/s41467-023-40410-x ]
- 16f (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anoctamin-6 (95 kDa, Protein from Mus musculus)
Human Kv4.2-KChIP2 channel complex in an open state, transmembrane region
Human Kv4.2-KChIP2 channel complex in an inactivated state, class 1, transmembrane region
Human Kv4.2-KChIP2 channel complex in an inactivated state, class 2, transmembrane region
Human Kv4.2-KChIP2 channel complex in an intermediate state, transmembrane region
Human Kv4.2-KChIP2 channel complex in a putative resting state, transmembrane region
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 7ukf
Q-score: 0.478
Ye W, Zhao H, Dai Y, Wang Y, Lo YH, Jan LY, Lee CH
Mol Cell (2022) 82 pp. 2427- [ DOI: doi:10.1016/j.molcel.2022.04.032 Pubmed: 35597238 ]
- Potassium voltage-gated channel subfamily d member 2 (59 kDa, Protein from Homo sapiens)
- Human kv4.2-kchip2 channel complex in a putative resting state, transmembrane region (Complex from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Mercury (ii) ion (200 Da, Ligand)