OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 6h03
Q-score: 0.156
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ DOI: doi:10.1038/s41467-018-07653-5 Pubmed: 30552328 ]
- C6 (Complex from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- Complement component c8 alpha chain (61 kDa, Protein from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- Complement component c8 gamma chain (20 kDa, Protein from Homo sapiens)
- Complement c5,complement c5 (177 kDa, Protein from Homo sapiens)
- Complement component c6 (102 kDa, Protein from Homo sapiens)
- Complement component c7 (91 kDa, Protein from Homo sapiens)
- Complement component c8 beta chain (61 kDa, Protein from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- Complement component c9 (61 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- C7 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
Closed conformation of the Membrane Attack Complex
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 6h04
Q-score: 0.179
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ DOI: doi:10.1038/s41467-018-07653-5 Pubmed: 30552328 ]
- C6 (Complex from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- Complement component c8 alpha chain (61 kDa, Protein from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- Complement component c8 gamma chain (20 kDa, Protein from Homo sapiens)
- Complement c5,complement c5 (177 kDa, Protein from Homo sapiens)
- Complement component c6 (102 kDa, Protein from Homo sapiens)
- Complement component c7 (91 kDa, Protein from Homo sapiens)
- Complement component c8 beta chain (61 kDa, Protein from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- Complement component c9 (61 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- C7 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
Asymmetric region of the Membrane Attack Complex in the closed conformation
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ DOI: doi:10.1038/s41467-018-07653-5 Pubmed: 30552328 ]
- C6 (Complex from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- C7 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
Consensus map of the Membrane Attack Complex
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ DOI: doi:10.1038/s41467-018-07653-5 Pubmed: 30552328 ]
- C6 (Complex from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- C7 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
Asymmetric region of the Membrane Attack Complex in the open conformation
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ DOI: doi:10.1038/s41467-018-07653-5 Pubmed: 30552328 ]
- C6 (Complex from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- C7 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
Hinge region of the Membrane Attack Complex in the open conformation
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ DOI: doi:10.1038/s41467-018-07653-5 Pubmed: 30552328 ]
- C6 (Complex from Homo sapiens)
- C8 gamma (Complex from Homo sapiens)
- C8 alpha (Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
- Membrane attack complex (69 kDa, Complex from Homo sapiens)
- C8 beta (Complex from Homo sapiens)
- C7 (Complex from Homo sapiens)
- C5b (Complex from Homo sapiens)
C9 oligomer region of the Membrane Attack Complex in the open conformation
Menny A, Serna M, Boyd CM, Gardner S, Joseph AP, Morgan BP, Topf M, Brooks NJ, Bubeck D
Nat Commun (2018) 9 pp. 5316-5316 [ DOI: doi:10.1038/s41467-018-07653-5 Pubmed: 30552328 ]
- Membrane attack complex (690 kDa, Complex from Homo sapiens)
- C9 (Complex from Homo sapiens)
Molecular basis of human kinesin-8 function and inhibition
Resolution: 5.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 5oam
Q-score: 0.255
Locke J, Joseph AP, Pena A, Mockel MM, Mayer TU, Topf M, Moores CA
PNAS (2017) 114 pp. E9539-E9548 [ DOI: doi:10.1073/pnas.1712169114 Pubmed: 29078367 ]
- Tublin, beta (Complex from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tubulin, alpha (Complex from Bos taurus)
- 13-protofilament microtuble-bound human kinesin-8 motor domain neck-linker without nucleotide (Complex)
- Tubulin alpha chain (50 kDa, Protein from Bos taurus)
- Taxol (853 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Kinesin-8 motor domain neck-linker (Complex from Homo sapiens)
- Kinesin-like protein kif18a (42 kDa, Protein from Homo sapiens)
- Tubulin beta chain (49 kDa, Protein from Sus scrofa)
Molecular basis of human kinesin-8 function and inhibition
Resolution: 5.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 5ocu
Q-score: 0.26
Locke J, Joseph AP, Pena A, Mockel MM, Mayer TU, Topf M, Moores CA
PNAS (2017) 114 pp. E9539-E9548 [ DOI: doi:10.1073/pnas.1712169114 Pubmed: 29078367 ]
- Tubulin, beta (Complex from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tubulin, alpha (Complex from Bos taurus)
- Tubulin alpha chain (50 kDa, Protein from Bos taurus)
- Taxol (853 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- 13-protofilament microtuble-bound human kinesin-8 motor domain neck-linker with amppnp (Complex)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Kinesin-8 motor domain neck-linker (Complex from Homo sapiens)
- Kinesin-like protein kif18a (42 kDa, Protein from Homo sapiens)
- Tubulin beta chain (49 kDa, Protein from Sus scrofa)
Molecular basis of human kinesin-8 function and inhibition
Locke J, Joseph AP, Pena A, Mockel MM, Mayer TU, Topf M, Moores CA
PNAS (2017) 114 pp. E9539-E9548 [ DOI: doi:10.1073/pnas.1712169114 Pubmed: 29078367 ]
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tubulin beta chain (Complex from sus scrofa)
- Tubulin alpha chain (50 kDa, Protein from Bos taurus)
- 4-chloranyl-2-nitro-1-(phenylsulfonyl)benzene (297 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Taxol (853 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Kinesin-8 motor domain neck-linker (Complex from Homo sapiens)
- Kinesin-like protein kif18a (42 kDa, Protein from Homo sapiens)
- Tubulin beta chain (49 kDa, Protein from Sus scrofa)
- 13-protofilament microtuble-bound human kinesin-8 motor domain neck-linker with its specific inhibitor btb-1 (Complex)
- Tubulin alpha chain (Complex from Bos taurus)