cryoEM structure of SARS-CoV2 Spike trimer in complex with Fab23
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8q5y
Q-score: 0.516
Mandolesi M, Das H, de Vries L, Yang Y, Kim C, Dhinakaran M, Castro Dopico X, Fischbach J, Kim S, Guryleva MV, Adori M, Chernyshev M, Stalmarck A, Hanke L, McInerney GM, Sheward DJ, Corcoran M, Hallberg BM, Murrell B, Karlsson Hedestam GB
Nat Commun (2024) 15 pp. 6338-6338 [ DOI: doi:10.1038/s41467-024-50286-0 Pubmed: 39068149 ]
- Sars-cov2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- Monoclonal antibody mab 23 (light chain) (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Monoclonal antibody mab 23 (heavy chain) (48 kDa, Protein from Homo sapiens)
SARS-CoV-2 Spike RBD in complex with Mab-23 (Fab)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8p5m
Q-score: 0.554
Mandolesi M, Das H, de Vries L, Yang Y, Kim C, Dhinakaran M, Castro Dopico X, Fischbach J, Kim S, Guryleva MV, Adori M, Chernyshev M, Stalmarck A, Hanke L, McInerney GM, Sheward DJ, Corcoran M, Hallberg BM, Murrell B, Karlsson Hedestam GB
Nat Commun (2024) 15 pp. 6338-6338 [ DOI: doi:10.1038/s41467-024-50286-0 Pubmed: 39068149 ]
- Mab-23 (heavy chain variable domain) (48 kDa, Protein from Homo sapiens)
- Monoclonal antibody mab-23 (Complex from Enterobacteria phage T4)
- Mab-23 (light chain variable domain) (23 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike rbd (two molecules) in complex with two fu2 nanobodies (95 kDa, Complex)
- Sars-cov-2 spike (rbd) (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing nanobodies (Ty1)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 6zxn
Q-score: 0.468
Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, Corcoran M, Achour A, Karlsson Hedestam GB, Hallberg BM, Murrell B, McInerney GM
Nat Commun (2020) 11 pp. 4420-4420 [ Pubmed: 32887876 DOI: doi:10.1038/s41467-020-18174-5 ]
- Nanobody ty1 (Complex from Vicugna pacos)
- Nanobody ty1 (14 kDa, Protein from Vicugna pacos)
- Ternary complex between nanobody ty1 and spike. (14 kDa, Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nanobody strongly neutralising and blocks ace2 binding. (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 spike glycoprotein bound to nanobodies (Ty1)
Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, Corcoran M, Achour A, Karlsson Hedestam GB, Hallberg BM, Murrell B, McInerney GM
Nat Commun (2020) 11 pp. 4420-4420 [ Pubmed: 32887876 DOI: doi:10.1038/s41467-020-18174-5 ]