BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibodies 3BNC117 and PGT145
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 5v8l
Q-score: 0.346
Lee JH, Andrabi R, Su CY, Yasmeen A, Julien JP, Kong L, Wu NC, McBride R, Sok D, Pauthner M, Cottrell CA, Nieusma T, Blattner C, Paulson JC, Klasse PJ, Wilson IA, Burton DR, Ward AB
Immunity (2017) 46 pp. 690-702 [ DOI: doi:10.1016/j.immuni.2017.03.017 Pubmed: 28423342 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 sosip.664 trimer in complex with pgt145 and 3bnc117 fabs (560 kDa, Complex from Human immunodeficiency virus 1)
- 3bnc117 antibody, light chain (23 kDa, Protein from Homo sapiens)
- Pgt145 antibody, heavy chain (28 kDa, Protein from Homo sapiens)
- Pgt145 antibody, light chain (23 kDa, Protein from Homo sapiens)
- 3bnc117 antibody, heavy chain (24 kDa, Protein from Homo sapiens)
- Gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibody 3BNC117
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 5v8m
Q-score: 0.347
Lee JH, Andrabi R, Su CY, Yasmeen A, Julien JP, Kong L, Wu NC, McBride R, Sok D, Pauthner M, Cottrell CA, Nieusma T, Blattner C, Paulson JC, Klasse PJ, Wilson IA, Burton DR, Ward AB
Immunity (2017) 46 pp. 690-702 [ DOI: doi:10.1016/j.immuni.2017.03.017 Pubmed: 28423342 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505 sosip.664 soluble env trimer in complex with 3bnc117 fab (510 kDa, Complex from Homo sapiens)
- Antibody 3bnc117, light chain (23 kDa, Protein from Homo sapiens)
- Gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Antibody 3bnc117, heavy chain (24 kDa, Protein from Homo sapiens)
- Gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
Negative stain EM reconstruction of HIV-1 Env AMC008 SOSIP.v4 in complex with Fabs 35O22 and PGV04
de Taeye SW, Ozorowski G, Torrents de la Pena A, Guttman M, Julien JP, van den Kerkhof TL, Burger JA, Pritchard LK, Pugach P, Yasmeen A, Crampton J, Hu J, Bontjer I, Torres JL, Arendt H, DeStefano J, Koff WC, Schuitemaker H, Eggink D, Berkhout B, Dean H, LaBranche C, Crotty S, Crispin M, Montefiori DC, Klasse PJ, Lee KK, Moore JP, Wilson IA, Ward AB, Sanders RW
Cell (2015) 163 pp. 1702-1715 [ Pubmed: 26687358 DOI: doi:10.1016/j.cell.2015.11.056 ]
- Anti-hiv-1 antibody 35o22 fab (50 kDa, Protein from Homo sapiens)
- Hiv-1 amc008 env sosip.v4 (420 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 env amc008 sosip.v4 in complex with broadly neutralizing antibody fabs 35o22 and pgv04 (720 kDa, Sample)
- Anti-hiv-1 antibody pgv04 fab (50 kDa, Protein from Homo sapiens)
Cryo-EM structure of the BG505 SOSIP.664 HIV-1 Env trimer with 3 PGV04 Fabs
Resolution: 5.8 Å
EM Method: Single-particle
Fitted PDBs: 3j5m
Q-score: 0.156
Lyumkis D, Julien JP, de Val N, Cupo A, Potter CS, Klasse PJ, Burton DR, Sanders RW, Moore JP, Carragher B, Wilson IA, Ward AB
Science (2013) 342 pp. 1484-1490 [ Pubmed: 24179160 DOI: doi:10.1126/science.1245627 ]
Cryo-EM structure of the BG505 SOSIP.664 HIV-1 Env trimer with 2 PGV04 Fabs
Lyumkis D, Julien JP, de Val N, Cupo A, Potter CS, Klasse PJ, Burton DR, Sanders RW, Moore JP, Carragher B, Wilson IA, Ward AB
Science (2013) 342 pp. 1484-1490 [ Pubmed: 24179160 DOI: doi:10.1126/science.1245627 ]
Cryo-EM structure of the BG505 SOSIP.650 HIV-1 Env trimer with 3 PGV04 Fabs
Lyumkis D, Julien JP, de Val N, Cupo A, Potter CS, Klasse PJ, Burton DR, Sanders RW, Moore JP, Carragher B, Wilson IA, Ward AB
Science (2013) 342 pp. 1484-1490 [ Pubmed: 24179160 DOI: doi:10.1126/science.1245627 ]
Cryo-EM structure of the BG505 SOSIP.664 HIV-1 Env trimer
Lyumkis D, Julien JP, de Val N, Cupo A, Potter CS, Klasse PJ, Burton DR, Sanders RW, Moore JP, Carragher B, Wilson IA, Ward AB
Science (2013) 342 pp. 1484-1490 [ Pubmed: 24179160 DOI: doi:10.1126/science.1245627 ]