BG505 GT1.1 SOSIP in complex with NHP Fabs 12C11 and RM20A3
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8sw3
Q-score: 0.564
Caniels TG, Medina-Ramirez M, Zhang S, Kratochvil S, Xian Y, Koo JH, Derking R, Samsel J, van Schooten J, Pecetta S, Lamperti E, Yuan M, Carrasco MR, Del Moral Sanchez I, Allen JD, Bouhuijs JH, Yasmeen A, Ketas TJ, Snitselaar JL, Bijl TPL, Martin IC, Torres JL, Cupo A, Shirreff L, Rogers K, Mason RD, Roederer M, Greene KM, Gao H, Silva CM, Baken IJL, Tian M, Alt FW, Pulendran B, Seaman MS, Crispin M, van Gils MJ, Montefiori DC, McDermott AB, Villinger FJ, Koup RA, Moore JP, Klasse PJ, Ozorowski G, Batista FD, Wilson IA, Ward AB, Sanders RW
Sci Immunol (2024) 9 pp. eadk9550-eadk9550 [ Pubmed: 39213338 DOI: doi:10.1126/sciimmunol.adk9550 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Rm20a3 light chain variable region (11 kDa, Protein from Macaca)
- Bg505 gt1.1 sosip gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 gt1.1 sosip in complex with 12c11 fab and rm20a3 fab (720 kDa, Complex from Macaca)
- 12c11 light chain variable region (11 kDa, Protein from Macaca)
- Rm20a3 heavy chain variable region (13 kDa, Protein from Macaca)
- 12c11 heavy chain variable region (14 kDa, Protein from Macaca)
BG505 GT1.1 SOSIP in complex with NHP Fabs 21N13, 21M20 and RM20A3
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8sw4
Q-score: 0.567
Caniels TG, Medina-Ramirez M, Zhang S, Kratochvil S, Xian Y, Koo JH, Derking R, Samsel J, van Schooten J, Pecetta S, Lamperti E, Yuan M, Carrasco MR, Del Moral Sanchez I, Allen JD, Bouhuijs JH, Yasmeen A, Ketas TJ, Snitselaar JL, Bijl TPL, Martin IC, Torres JL, Cupo A, Shirreff L, Rogers K, Mason RD, Roederer M, Greene KM, Gao H, Silva CM, Baken IJL, Tian M, Alt FW, Pulendran B, Seaman MS, Crispin M, van Gils MJ, Montefiori DC, McDermott AB, Villinger FJ, Koup RA, Moore JP, Klasse PJ, Ozorowski G, Batista FD, Wilson IA, Ward AB, Sanders RW
Sci Immunol (2024) 9 pp. eadk9550-eadk9550 [ Pubmed: 39213338 DOI: doi:10.1126/sciimmunol.adk9550 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505 gt1.1 sosip in complex with 21n13 fab, 21m20 fab and rm20a3 fab (770 kDa, Complex from Macaca)
- Rm20a3 heavy chain variable region (13 kDa, Protein from Macaca)
- 21n13 light chain variable region (11 kDa, Protein from Macaca)
- 21m20 light chain variable region (11 kDa, Protein from Macaca)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 gt1.1 sosip gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Rm20a3 light chain variable region (11 kDa, Protein from Macaca)
- 21n13 heavy chain variable region (14 kDa, Protein from Macaca)
- 21m20 heavy chain variable region (13 kDa, Protein from Macaca)
HIV-1 Env subtype C CZA97.12 SOSIP.664 in complex with 3BNC117 Fab
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8gje
Q-score: 0.451
Ringe RP, Colin P, Ozorowski G, Allen JD, Yasmeen A, Seabright GE, Lee JH, Antanasijevic A, Rantalainen K, Ketas T, Moore JP, Ward AB, Crispin M, Klasse PJ
PLoS Pathog (2023) 19 pp. e1011601-e1011601 [ Pubmed: 37903160 DOI: doi:10.1371/journal.ppat.1011601 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cza97.12 sosip.664 envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cza97.12 sosip.664 in complex with 3bnc117 fab (570 kDa, Complex)
- 3bnc117 fab heavy chain (24 kDa, Protein from Homo sapiens)
- 3bnc117 kappa light chain (23 kDa, Protein from Homo sapiens)
- Cza97.12 sosip.664 envelope glycoprotein gp120 (56 kDa, Protein from Human immunodeficiency virus 1)
AMC018 SOSIP.v4.2 in complex with PGV04 Fab
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 7rsn
Q-score: 0.447
Schorcht A, Cottrell CA, Pugach P, Ringe RP, Han AX, Allen JD, van den Kerkhof TLGM, Seabright GE, Schermer EE, Ketas TJ, Burger JA, van Schooten J, LaBranche CC, Ozorowski G, de Val N, Bader DLV, Schuitemaker H, Russell CA, Montefiori DC, van Gils MJ, Crispin M, Klasse PJ, Ward AB, Moore JP, Sanders RW
J Virol (2022) 96 pp. e0155221-e0155221 [ Pubmed: 34669426 DOI: doi:10.1128/JVI.01552-21 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Amc018 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Amc018 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Pgv04 kappa chain (23 kDa, Protein from Homo sapiens)
- Amc018 sosip.v4.2 in complex with pgv04 fab (Complex from Human immunodeficiency virus 1)
- Pgv04 fab heavy chain (24 kDa, Protein from Homo sapiens)
AMC016 SOSIP.v4.2 in complex with PGV04 Fab
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7rso
Q-score: 0.349
Schorcht A, Cottrell CA, Pugach P, Ringe RP, Han AX, Allen JD, van den Kerkhof TLGM, Seabright GE, Schermer EE, Ketas TJ, Burger JA, van Schooten J, LaBranche CC, Ozorowski G, de Val N, Bader DLV, Schuitemaker H, Russell CA, Montefiori DC, van Gils MJ, Crispin M, Klasse PJ, Ward AB, Moore JP, Sanders RW
J Virol (2022) 96 pp. e0155221-e0155221 [ Pubmed: 34669426 DOI: doi:10.1128/JVI.01552-21 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Amc016 sosip.v4.2 in complex with pgv04 fab (Complex from Human immunodeficiency virus 1)
- Pgv04 kappa chain (23 kDa, Protein from Homo sapiens)
- Amc016 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Amc016 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Pgv04 fab heavy chain (24 kDa, Protein from Homo sapiens)
BG505 SOSIPv5.2 in complex with PGT122 and two RM20E1 Fabs
Derking R, Allen JD, Cottrell CA, Sliepen K, Seabright GE, Lee WH, Aldon Y, Rantalainen K, Antanasijevic A, Copps J, Yasmeen A, Cupo A, Cruz Portillo VM, Poniman M, Bol N, van der Woude P, de Taeye SW, van den Kerkhof TLGM, Klasse PJ, Ozorowski G, van Gils MJ, Moore JP, Ward AB, Crispin M, Sanders RW
Cell Rep (2021) 35 pp. 108933-108933 [ Pubmed: 33826885 DOI: doi:10.1016/j.celrep.2021.108933 ]
BG505 SOSIPv5.2 in complex with PGT122 and three RM20E1 Fabs
Derking R, Allen JD, Cottrell CA, Sliepen K, Seabright GE, Lee WH, Aldon Y, Rantalainen K, Antanasijevic A, Copps J, Yasmeen A, Cupo A, Cruz Portillo VM, Poniman M, Bol N, van der Woude P, de Taeye SW, van den Kerkhof TLGM, Klasse PJ, Ozorowski G, van Gils MJ, Moore JP, Ward AB, Crispin M, Sanders RW
Cell Rep (2021) 35 pp. 108933-108933 [ Pubmed: 33826885 DOI: doi:10.1016/j.celrep.2021.108933 ]
C3 symmetric BG505 SOSIPv5.2 in complex with PGT122 and three RM20E1 Fabs
Derking R, Allen JD, Cottrell CA, Sliepen K, Seabright GE, Lee WH, Aldon Y, Rantalainen K, Antanasijevic A, Copps J, Yasmeen A, Cupo A, Cruz Portillo VM, Poniman M, Bol N, van der Woude P, de Taeye SW, van den Kerkhof TLGM, Klasse PJ, Ozorowski G, van Gils MJ, Moore JP, Ward AB, Crispin M, Sanders RW
Cell Rep (2021) 35 pp. 108933-108933 [ Pubmed: 33826885 DOI: doi:10.1016/j.celrep.2021.108933 ]
BG505 SOSIPv5.2 in complex with PGT122 and one RM20E1 Fab
Derking R, Allen JD, Cottrell CA, Sliepen K, Seabright GE, Lee WH, Aldon Y, Rantalainen K, Antanasijevic A, Copps J, Yasmeen A, Cupo A, Cruz Portillo VM, Poniman M, Bol N, van der Woude P, de Taeye SW, van den Kerkhof TLGM, Klasse PJ, Ozorowski G, van Gils MJ, Moore JP, Ward AB, Crispin M, Sanders RW
Cell Rep (2021) 35 pp. 108933-108933 [ Pubmed: 33826885 DOI: doi:10.1016/j.celrep.2021.108933 ]
BG505 SOSIPv5.2 in complex with PGT122 and no RM20E1 Fabs
Derking R, Allen JD, Cottrell CA, Sliepen K, Seabright GE, Lee WH, Aldon Y, Rantalainen K, Antanasijevic A, Copps J, Yasmeen A, Cupo A, Cruz Portillo VM, Poniman M, Bol N, van der Woude P, de Taeye SW, van den Kerkhof TLGM, Klasse PJ, Ozorowski G, van Gils MJ, Moore JP, Ward AB, Crispin M, Sanders RW
Cell Rep (2021) 35 pp. 108933-108933 [ Pubmed: 33826885 DOI: doi:10.1016/j.celrep.2021.108933 ]