BG505 SOSIPv5.2 in complex with PGT122 and two RM20E1 Fabs
Derking R, Allen JD, Cottrell CA, Sliepen K, Seabright GE, Lee WH, Aldon Y, Rantalainen K, Antanasijevic A, Copps J, Yasmeen A, Cupo A, Cruz Portillo VM, Poniman M, Bol N, van der Woude P, de Taeye SW, van den Kerkhof TLGM, Klasse PJ, Ozorowski G, van Gils MJ, Moore JP, Ward AB, Crispin M, Sanders RW
Cell Rep (2021) 35 pp. 108933-108933 [ Pubmed: 33826885 DOI: doi:10.1016/j.celrep.2021.108933 ]
BG505 SOSIPv5.2 in complex with PGT122 and three RM20E1 Fabs
Derking R, Allen JD, Cottrell CA, Sliepen K, Seabright GE, Lee WH, Aldon Y, Rantalainen K, Antanasijevic A, Copps J, Yasmeen A, Cupo A, Cruz Portillo VM, Poniman M, Bol N, van der Woude P, de Taeye SW, van den Kerkhof TLGM, Klasse PJ, Ozorowski G, van Gils MJ, Moore JP, Ward AB, Crispin M, Sanders RW
Cell Rep (2021) 35 pp. 108933-108933 [ Pubmed: 33826885 DOI: doi:10.1016/j.celrep.2021.108933 ]
C3 symmetric BG505 SOSIPv5.2 in complex with PGT122 and three RM20E1 Fabs
Derking R, Allen JD, Cottrell CA, Sliepen K, Seabright GE, Lee WH, Aldon Y, Rantalainen K, Antanasijevic A, Copps J, Yasmeen A, Cupo A, Cruz Portillo VM, Poniman M, Bol N, van der Woude P, de Taeye SW, van den Kerkhof TLGM, Klasse PJ, Ozorowski G, van Gils MJ, Moore JP, Ward AB, Crispin M, Sanders RW
Cell Rep (2021) 35 pp. 108933-108933 [ Pubmed: 33826885 DOI: doi:10.1016/j.celrep.2021.108933 ]
BG505 SOSIPv5.2 in complex with PGT122 and one RM20E1 Fab
Derking R, Allen JD, Cottrell CA, Sliepen K, Seabright GE, Lee WH, Aldon Y, Rantalainen K, Antanasijevic A, Copps J, Yasmeen A, Cupo A, Cruz Portillo VM, Poniman M, Bol N, van der Woude P, de Taeye SW, van den Kerkhof TLGM, Klasse PJ, Ozorowski G, van Gils MJ, Moore JP, Ward AB, Crispin M, Sanders RW
Cell Rep (2021) 35 pp. 108933-108933 [ Pubmed: 33826885 DOI: doi:10.1016/j.celrep.2021.108933 ]
BG505 SOSIPv5.2 in complex with PGT122 and no RM20E1 Fabs
Derking R, Allen JD, Cottrell CA, Sliepen K, Seabright GE, Lee WH, Aldon Y, Rantalainen K, Antanasijevic A, Copps J, Yasmeen A, Cupo A, Cruz Portillo VM, Poniman M, Bol N, van der Woude P, de Taeye SW, van den Kerkhof TLGM, Klasse PJ, Ozorowski G, van Gils MJ, Moore JP, Ward AB, Crispin M, Sanders RW
Cell Rep (2021) 35 pp. 108933-108933 [ Pubmed: 33826885 DOI: doi:10.1016/j.celrep.2021.108933 ]
C3 symmetric BG505 SOSIPv5.2 in complex with PGT122 and no RM20E1 Fabs
Derking R, Allen JD, Cottrell CA, Sliepen K, Seabright GE, Lee WH, Aldon Y, Rantalainen K, Antanasijevic A, Copps J, Yasmeen A, Cupo A, Cruz Portillo VM, Poniman M, Bol N, van der Woude P, de Taeye SW, van den Kerkhof TLGM, Klasse PJ, Ozorowski G, van Gils MJ, Moore JP, Ward AB, Crispin M, Sanders RW
Cell Rep (2021) 35 pp. 108933-108933 [ Pubmed: 33826885 DOI: doi:10.1016/j.celrep.2021.108933 ]
De novo designed icosahedral nanoparticle I53_dn5 presenting BG505-SOSIP, Cryo-EM Map
Antanasijevic A, Ueda G, Brouwer PJM, Copps J, Huang D, Allen JD, Cottrell CA, Yasmeen A, Sewall LM, Bontjer I, Ketas TJ, Turner HL, Berndsen ZT, Montefiori DC, Klasse PJ, Crispin M, Nemazee D, Moore JP, Sanders RW, King NP, Baker D, Ward AB
PLoS Pathog (2020) 16 pp. e1008665-e1008665 [ Pubmed: 32780770 DOI: doi:10.1371/journal.ppat.1008665 ]
- De novo designed icosahedral nanoparticle i53_dn5 displaying 20 copies of bg505-sosip trimer on the surface. nanoparticle consists of 60 copies of both subunits (bg505-sosip-i53_dn5b and i53_dn5a) (Complex from synthetic construct)
- Bg505-sosip-i53_dn5b (Protein from synthetic construct)
- I53_dn5a (Protein from synthetic construct)
Antanasijevic A, Ueda G, Brouwer PJM, Copps J, Huang D, Allen JD, Cottrell CA, Yasmeen A, Sewall LM, Bontjer I, Ketas TJ, Turner HL, Berndsen ZT, Montefiori DC, Klasse PJ, Crispin M, Nemazee D, Moore JP, Sanders RW, King NP, Baker D, Ward AB
PLoS Pathog (2020) 16 pp. e1008665-e1008665 [ Pubmed: 32780770 DOI: doi:10.1371/journal.ppat.1008665 ]
Resolution: 4.25 Å
EM Method: Single-particle
Fitted PDBs: 6vfk
Q-score: 0.316
Antanasijevic A, Ueda G, Brouwer PJM, Copps J, Huang D, Allen JD, Cottrell CA, Yasmeen A, Sewall LM, Bontjer I, Ketas TJ, Turner HL, Berndsen ZT, Montefiori DC, Klasse PJ, Crispin M, Nemazee D, Moore JP, Sanders RW, King NP, Baker D, Ward AB
PLoS Pathog (2020) 16 pp. e1008665-e1008665 [ Pubmed: 32780770 DOI: doi:10.1371/journal.ppat.1008665 ]
- T33_dn10b (31 kDa, Protein from synthetic construct)
- De novo designed tetrahedral nanoparticle t33_dn10 displaying 4 copies of bg505-sosip trimer on the surface. nanoparticle consists of 12 copies of both subunits (bg505-sosip-t33_dn10a and t33_dn10b) (Complex from synthetic construct)
- Bg505-sosip-t33_dn10a (88 kDa, Protein from synthetic construct)
Resolution: 4.14 Å
EM Method: Single-particle
Fitted PDBs: 6vfl
Q-score: 0.404
Antanasijevic A, Ueda G, Brouwer PJM, Copps J, Huang D, Allen JD, Cottrell CA, Yasmeen A, Sewall LM, Bontjer I, Ketas TJ, Turner HL, Berndsen ZT, Montefiori DC, Klasse PJ, Crispin M, Nemazee D, Moore JP, Sanders RW, King NP, Baker D, Ward AB
PLoS Pathog (2020) 16 pp. e1008665-e1008665 [ Pubmed: 32780770 DOI: doi:10.1371/journal.ppat.1008665 ]
- Bg505-sosipv5.2(7s) - gp41 (17 kDa, Protein from synthetic construct)
- Bg505-sosipv5.2(7s) - gp120 (56 kDa, Protein from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505-sosip reconstructed from the tetrahedral nanoparticle t33_dn10 by subparticle extraction and refinement (Complex from synthetic construct)