BG505 GT1.1 SOSIP in complex with NHP Fabs 12C11 and RM20A3
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8sw3
Q-score: 0.564
Caniels TG, Medina-Ramirez M, Zhang S, Kratochvil S, Xian Y, Koo JH, Derking R, Samsel J, van Schooten J, Pecetta S, Lamperti E, Yuan M, Carrasco MR, Del Moral Sanchez I, Allen JD, Bouhuijs JH, Yasmeen A, Ketas TJ, Snitselaar JL, Bijl TPL, Martin IC, Torres JL, Cupo A, Shirreff L, Rogers K, Mason RD, Roederer M, Greene KM, Gao H, Silva CM, Baken IJL, Tian M, Alt FW, Pulendran B, Seaman MS, Crispin M, van Gils MJ, Montefiori DC, McDermott AB, Villinger FJ, Koup RA, Moore JP, Klasse PJ, Ozorowski G, Batista FD, Wilson IA, Ward AB, Sanders RW
Sci Immunol (2024) 9 pp. eadk9550-eadk9550 [ Pubmed: 39213338 DOI: doi:10.1126/sciimmunol.adk9550 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Rm20a3 light chain variable region (11 kDa, Protein from Macaca)
- Bg505 gt1.1 sosip gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 gt1.1 sosip in complex with 12c11 fab and rm20a3 fab (720 kDa, Complex from Macaca)
- 12c11 light chain variable region (11 kDa, Protein from Macaca)
- Rm20a3 heavy chain variable region (13 kDa, Protein from Macaca)
- 12c11 heavy chain variable region (14 kDa, Protein from Macaca)
BG505 GT1.1 SOSIP in complex with NHP Fabs 21N13, 21M20 and RM20A3
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8sw4
Q-score: 0.567
Caniels TG, Medina-Ramirez M, Zhang S, Kratochvil S, Xian Y, Koo JH, Derking R, Samsel J, van Schooten J, Pecetta S, Lamperti E, Yuan M, Carrasco MR, Del Moral Sanchez I, Allen JD, Bouhuijs JH, Yasmeen A, Ketas TJ, Snitselaar JL, Bijl TPL, Martin IC, Torres JL, Cupo A, Shirreff L, Rogers K, Mason RD, Roederer M, Greene KM, Gao H, Silva CM, Baken IJL, Tian M, Alt FW, Pulendran B, Seaman MS, Crispin M, van Gils MJ, Montefiori DC, McDermott AB, Villinger FJ, Koup RA, Moore JP, Klasse PJ, Ozorowski G, Batista FD, Wilson IA, Ward AB, Sanders RW
Sci Immunol (2024) 9 pp. eadk9550-eadk9550 [ Pubmed: 39213338 DOI: doi:10.1126/sciimmunol.adk9550 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505 gt1.1 sosip in complex with 21n13 fab, 21m20 fab and rm20a3 fab (770 kDa, Complex from Macaca)
- Rm20a3 heavy chain variable region (13 kDa, Protein from Macaca)
- 21n13 light chain variable region (11 kDa, Protein from Macaca)
- 21m20 light chain variable region (11 kDa, Protein from Macaca)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 gt1.1 sosip gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Rm20a3 light chain variable region (11 kDa, Protein from Macaca)
- 21n13 heavy chain variable region (14 kDa, Protein from Macaca)
- 21m20 heavy chain variable region (13 kDa, Protein from Macaca)
HIV-1 Env subtype C CZA97.12 SOSIP.664 in complex with 3BNC117 Fab
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8gje
Q-score: 0.451
Ringe RP, Colin P, Ozorowski G, Allen JD, Yasmeen A, Seabright GE, Lee JH, Antanasijevic A, Rantalainen K, Ketas T, Moore JP, Ward AB, Crispin M, Klasse PJ
PLoS Pathog (2023) 19 pp. e1011601-e1011601 [ Pubmed: 37903160 DOI: doi:10.1371/journal.ppat.1011601 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cza97.12 sosip.664 envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cza97.12 sosip.664 in complex with 3bnc117 fab (570 kDa, Complex)
- 3bnc117 fab heavy chain (24 kDa, Protein from Homo sapiens)
- 3bnc117 kappa light chain (23 kDa, Protein from Homo sapiens)
- Cza97.12 sosip.664 envelope glycoprotein gp120 (56 kDa, Protein from Human immunodeficiency virus 1)
AMC018 SOSIP.v4.2 in complex with PGV04 Fab
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 7rsn
Q-score: 0.447
Schorcht A, Cottrell CA, Pugach P, Ringe RP, Han AX, Allen JD, van den Kerkhof TLGM, Seabright GE, Schermer EE, Ketas TJ, Burger JA, van Schooten J, LaBranche CC, Ozorowski G, de Val N, Bader DLV, Schuitemaker H, Russell CA, Montefiori DC, van Gils MJ, Crispin M, Klasse PJ, Ward AB, Moore JP, Sanders RW
J Virol (2022) 96 pp. e0155221-e0155221 [ Pubmed: 34669426 DOI: doi:10.1128/JVI.01552-21 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Amc018 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Amc018 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Pgv04 kappa chain (23 kDa, Protein from Homo sapiens)
- Amc018 sosip.v4.2 in complex with pgv04 fab (Complex from Human immunodeficiency virus 1)
- Pgv04 fab heavy chain (24 kDa, Protein from Homo sapiens)
AMC016 SOSIP.v4.2 in complex with PGV04 Fab
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7rso
Q-score: 0.349
Schorcht A, Cottrell CA, Pugach P, Ringe RP, Han AX, Allen JD, van den Kerkhof TLGM, Seabright GE, Schermer EE, Ketas TJ, Burger JA, van Schooten J, LaBranche CC, Ozorowski G, de Val N, Bader DLV, Schuitemaker H, Russell CA, Montefiori DC, van Gils MJ, Crispin M, Klasse PJ, Ward AB, Moore JP, Sanders RW
J Virol (2022) 96 pp. e0155221-e0155221 [ Pubmed: 34669426 DOI: doi:10.1128/JVI.01552-21 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Amc016 sosip.v4.2 in complex with pgv04 fab (Complex from Human immunodeficiency virus 1)
- Pgv04 kappa chain (23 kDa, Protein from Homo sapiens)
- Amc016 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Amc016 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Pgv04 fab heavy chain (24 kDa, Protein from Homo sapiens)
AMC009 SOSIP.v4.2 in complex with PGV04 Fab
Resolution: 4.25 Å
EM Method: Single-particle
Fitted PDBs: 6vo3
Q-score: 0.29
Schorcht A, van den Kerkhof TLGM, Cottrell CA, Allen JD, Torres JL, Behrens AJ, Schermer EE, Burger JA, de Taeye SW, Torrents de la Pena A, Bontjer I, Gumbs S, Ozorowski G, LaBranche CC, de Val N, Yasmeen A, Klasse PJ, Montefiori DC, Moore JP, Schuitemaker H, Crispin M, van Gils MJ, Ward AB, Sanders RW
J Virol (2020) 94 [ DOI: doi:10.1128/JVI.01214-20 Pubmed: 32999024 ]
- Amc009 sosip.v4.2 in complex with pgv04 fab (Complex)
- Amc009 sosip.v4.2 envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Amc009 sosip.v4.2 (Complex from Human immunodeficiency virus 1)
- Pgv04 fab (Complex from Homo sapiens)
- Amc009 sosip.v4.2 envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Pgv04 light chain (23 kDa, Protein from Homo sapiens)
- Pgv04 heavy chain (24 kDa, Protein from Homo sapiens)
BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibodies 3BNC117 and PGT145
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 5v8l
Q-score: 0.346
Lee JH, Andrabi R, Su CY, Yasmeen A, Julien JP, Kong L, Wu NC, McBride R, Sok D, Pauthner M, Cottrell CA, Nieusma T, Blattner C, Paulson JC, Klasse PJ, Wilson IA, Burton DR, Ward AB
Immunity (2017) 46 pp. 690-702 [ DOI: doi:10.1016/j.immuni.2017.03.017 Pubmed: 28423342 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 3bnc117 antibody, light chain (23 kDa, Protein from Homo sapiens)
- Gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 sosip.664 trimer in complex with pgt145 and 3bnc117 fabs (560 kDa, Complex from Human immunodeficiency virus 1)
- Pgt145 antibody, heavy chain (28 kDa, Protein from Homo sapiens)
- Gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 3bnc117 antibody, heavy chain (24 kDa, Protein from Homo sapiens)
- Pgt145 antibody, light chain (23 kDa, Protein from Homo sapiens)
BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibody 3BNC117
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 5v8m
Q-score: 0.347
Lee JH, Andrabi R, Su CY, Yasmeen A, Julien JP, Kong L, Wu NC, McBride R, Sok D, Pauthner M, Cottrell CA, Nieusma T, Blattner C, Paulson JC, Klasse PJ, Wilson IA, Burton DR, Ward AB
Immunity (2017) 46 pp. 690-702 [ DOI: doi:10.1016/j.immuni.2017.03.017 Pubmed: 28423342 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Antibody 3bnc117, heavy chain (24 kDa, Protein from Homo sapiens)
- Bg505 sosip.664 soluble env trimer in complex with 3bnc117 fab (510 kDa, Complex from Homo sapiens)
- Gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Antibody 3bnc117, light chain (23 kDa, Protein from Homo sapiens)
van Gils MJ, van den Kerkhof TL, Ozorowski G, Cottrell CA, Sok D, Pauthner M, Pallesen J, de Val N, Yasmeen A, de Taeye SW, Schorcht A, Gumbs S, Johanna I, Saye-Francisco K, Liang CH, Landais E, Nie X, Pritchard LK, Crispin M, Kelsoe G, Wilson IA, Schuitemaker H, Klasse PJ, Moore JP, Burton DR, Ward AB, Sanders RW
Nat Microbiol (2016) 2 pp. 16199-16199 [ Pubmed: 27841852 DOI: doi:10.1038/nmicrobiol.2016.199 ]
- Amc011v.4.2_sosip (Protein from Human immunodeficiency virus 1)
- Pgv04 fab hc (Protein from Homo sapiens)
- Pgv04 fab lc (Protein from Homo sapiens)
- Hiv clade b env sosip ectodomain trimer from the amsterdam cohort study patient amc011 in complex with fab from igg pgv04 (600 kDa, Complex)
Negative stain Electron Microscopy of BG505 SOSIP.664 gp140 in complex with PGV04
Sanders RW, Derking R, Cupo A, Julien JP, Yasmeen A, de Val N, Kim HJ, Blattner C, Torrents A, Korzun J, Golabek M, de los Reyes K, Ketas TJ, van Gils MJ, King CR, Wilson IA, Ward AB, Klasse PJ, Moore JP
PLoS Pathog (2013) 9 pp. e1003618-e1003618 [ DOI: doi:10.1371/journal.ppat.1003618 Pubmed: 24068931 ]